DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aef1 and Kr

DIOPT Version :9

Sequence 1:	NP_001262157.1	Gene:	Aef1 / 40370	FlyBaseID:	FBgn0005694	Length:	454	Species:	Drosophila melanogaster
Sequence 2:	NP_001261181.1	Gene:	Kr / 38012	FlyBaseID:	FBgn0001325	Length:	502	Species:	Drosophila melanogaster

Alignment Length:	351	Identity:	98/351 - (27%)
Similarity:	150/351 - (42%)	Gaps:	67/351 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AAATA---------MSSNCDIVIVAAQ-PQTTIANNNNNETVTQATH-PAHMAAVQQQQQQQQQQ 65
            |||:|         :::|.......|| |.:|:||       |...| ||.:......||....|
  Fly    60 AAASAFGMLSPTQLLAANRQAAAFMAQLPMSTLAN-------TLFPHNPAALFGAWAAQQSLPPQ 117

  Fly    66 QQQHHQQQQQQSSGPPSVPPPPTELPLPFQMH---LSGISAEAHSAAQAAAMAAAQAAAAQAAAA 127
            ....|        .||:.|..|...||....|   ....:.:.|..|:.|...:.:...
  Fly   118 GTHLH--------SPPASPHSPLSTPLGSGKHPLNSPNSTPQHHEPAKKARKLSVKKEF------ 168

  Fly   128 EQQQPPPPTSHLTHLTTHSPTTIHSEHYLANGHSEHPGEGNAAVGVGGAVREP--EKPFHCTVCD 190
             |.:.....:.:.| |:..|.:..|..  ::.:|.|.|.|..| |..|..::|  :|.|.|.:|.
  Fly   169 -QTEISMSVNDMYH-TSGGPISPPSSG--SSPNSTHDGAGGNA-GCVGVSKDPSRDKSFTCKICS 228

  Fly   191 RRFRQLSTLTNHVKIHTGEKPYKCNVCDKTFRQSSTLTNHLKIHTGEKPYNCNFCPKHFRQLSTL 255
            |.|.....|.||.:.||||||::|..|.|.|.:...|..|:::|||||||:|:.|.:.|.|::.|
  Fly   229 RSFGYKHVLQNHERTHTGEKPFECPECHKRFTRDHHLKTHMRLHTGEKPYHCSHCDRQFVQVANL 293

  Fly   256 ANHVKIHTGEKPFECVICKKQFRQSSTLNNHIKIHVMDKVYVPVKIKTEEDEGXLGRMPLAAHH- 319
            ..|:::||||:|:.|.||..:|..|:.|.:|:.:|                   .|..|.....
  Fly   294 RRHLRVHTGERPYTCEICDGKFSDSNQLKSHMLVH-------------------NGEKPFECERC 339

  Fly   320 HQQQQHQHHHQQQQHQ---HHPPPPS 342
            |.:.:.:||  ...|:   ..||.|:
  Fly   340 HMKFRRRHH--LMNHKCGIQSPPTPA 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aef1	NP_001262157.1	C2H2 Zn finger	186..206	CDD:275368	7/19 (37%)
		zf-H2C2_2	199..223	CDD:290200	13/23 (57%)
		C2H2 Zn finger	214..234	CDD:275368	6/19 (32%)
		zf-H2C2_2	227..251	CDD:290200	12/23 (52%)
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		zf-H2C2_2	255..279	CDD:290200	11/23 (48%)
		C2H2 Zn finger	270..290	CDD:275368	7/19 (37%)
Kr	NP_001261181.1	C2H2 Zn finger	224..244	CDD:275368	7/19 (37%)
		zf-H2C2_2	237..261	CDD:290200	13/23 (57%)
		C2H2 Zn finger	252..272	CDD:275368	6/19 (32%)
		zf-H2C2_2	264..289	CDD:290200	12/24 (50%)
		C2H2 Zn finger	280..300	CDD:275368	6/19 (32%)
		zf-H2C2_2	292..316	CDD:290200	10/23 (43%)
		C2H2 Zn finger	308..328	CDD:275368	7/19 (37%)
		zf-H2C2_2	321..345	CDD:290200	6/42 (14%)
		C2H2 Zn finger	336..352	CDD:275368	3/17 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	60	1.000	Inparanoid score	I4014
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960