DRSC/TRiP Functional Genomics Resources

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Protein Alignment barc and HTATSF1

DIOPT Version :10

Sequence 1:NP_649313.1 Gene:barc / 40369 FlyBaseID:FBgn0037081 Length:556 Species:Drosophila melanogaster
Sequence 2:NP_055315.2 Gene:HTATSF1 / 27336 HGNCID:5276 Length:755 Species:Homo sapiens


Alignment Length:414 Identity:179/414 - (43%)
Similarity:250/414 - (60%) Gaps:37/414 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 DEQKKWVPKHPNPGQEGVCGVDEHGE-----RTYTDKDGVEFFWDATKSAWFPKIDDDFMARYQM 210
            |||.:....: ..|::|....|..||     :..||   ..:.||..|.||||||.:||:|.||.
Human    13 DEQLRMQELY-GDGKDGDTQTDAGGEPDSLGQQPTD---TPYEWDLDKKAWFPKITEDFIATYQA 73

  Fly   211 NYGFIDNTSAGEKEKAEKEAAEAKRKEEELKRMTAEAEAAMSRDNPASSAAVPTGKRKAQEPPK- 274
            ||||           :...|:.:....|::...|||       :.|...|..||..||..|..| 
Human    74 NYGF-----------SNDGASSSTANVEDVHARTAE-------EPPQEKAPEPTDARKKGEKRKA 120

  Fly   275 ---WFEMDPLQNTKVYVSNLPLDITMDEFADLMGKCGMVMRDPQTQKFKLKLYAEKDGQIKGDGL 336
               ||.::..:||.||||.||.|||:|||..||.|.|::||||||::||:|||.:..|.:|||||
Human   121 ESGWFHVEEDRNTNVYVSGLPPDITVDEFIQLMSKFGIIMRDPQTEEFKVKLYKDNQGNLKGDGL 185

  Fly   337 CDYIKVESVNLALKILDEYNLRGHKIRVQRAQFQMRGEYNPALKPKRKKKDKEKLQKMKEKLFDW 401
            |.|:|.|||.||||:|||..:||:|:.|:.|:||::|||: |.|.|:|.||.:|...|::|..||
Human   186 CCYLKRESVELALKLLDEDEIRGYKLHVEVAKFQLKGEYD-ASKKKKKCKDYKKKLSMQQKQLDW 249

  Fly   402 RPDKLRG-ERSKNEKTVIIKNLFTPELFEKEVELILEYQNNLREECSKCGMVRKVVIYDRHPDGV 465
            ||::..| .|.::|:.|||||:|.|..||.:..::.|.:.:||.||||.|.:||::::|||||||
Human   250 RPERRAGPSRMRHERVVIIKNMFHPMDFEDDPLVLNEIREDLRVECSKFGQIRKLLLFDRHPDGV 314

  Fly   466 AQINMASPEEADLVIQMMQGRYFGQRQLSAEAWDGKTKYKIEESAVEAHERLSKWDEFLAEEETD 530
            |.::...|||||..||.:.||:||.||::|:||||.|.|::||::.|..|||..|:.||...|  
Human   315 ASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSREREERLRGWEAFLNAPE-- 377

  Fly   531 KKASEDMKEEDVDSPENQLLPGDA 554
              |:..::..|..|...:..|..|
Human   378 --ANRGLRRSDSVSASERAGPSRA 399

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
barcNP_649313.1 RRM1_TatSF1_like 283..373 CDD:409723 55/89 (62%)
RRM2_TatSF1_like 414..504 CDD:409724 47/89 (53%)
HTATSF1NP_055315.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..53 10/43 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..122 13/47 (28%)
RRM1_TatSF1_like 132..222 CDD:409723 55/89 (62%)
U2AF homology motif (UHM). /evidence=ECO:0000269|PubMed:30567737 259..353 48/93 (52%)
RRM2_TatSF1_like 263..353 CDD:409724 47/89 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..415 4/20 (20%)
Mediates interaction with the P-TEFb complex. /evidence=ECO:0000269|PubMed:9649438 381..755 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 433..755
2A1904 <451..715 CDD:273344
Blue background indicates that the domain is not in the aligned region.

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