DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment barc and uap2

DIOPT Version :9

Sequence 1:	NP_649313.1	Gene:	barc / 40369	FlyBaseID:	FBgn0037081	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_596826.1	Gene:	uap2 / 2539783	PomBaseID:	SPBC1289.02c	Length:	367	Species:	Schizosaccharomyces pombe

Alignment Length:	396	Identity:	113/396 - (28%)
Similarity:	190/396 - (47%)	Gaps:	60/396 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 WDDEQKKWVPKHPNPGQEG--VCGVDEHGERTYTDKDGVEFFWDATKSAWFPKIDDDFMARYQMN 211
            ||:...:|    ...|.||  :..:||  |:|:.|.|              |.       ..:||
pombe     7 WDERIHRW----RCLGSEGNELIYIDE--EQTWKDYD--------------PN-------SLKMN 44

  Fly   212 YGFIDNTSAGEKEKAEKEAAEAKRKEEELKRMTAEAEAAMSRDNPASSAAVPTGKRKAQEPPKWF 276
            ..   .::..|......||.|.|.......|.|.....:      .|:...|:|.|..:...:..
pombe    45 KA---GSTGAEVSDVTAEATEGKESSNGEDRHTKRLYES------TSAEGYPSGSRNKKSKSENS 100

  Fly   277 EMD--PLQNTKVYVSNLPLDITMDEFADLMGKCGMVMRDPQTQKFKLKLYAEKDGQIKGDGLCDY 339
            |..  |:.|..||:..||||:|:||..::..|||::.::......::|:|..:||..|||.|..:
pombe   101 EASPAPVINKAVYIQGLPLDVTVDEIEEVFKKCGVIAKNIDNGTPRIKIYRTEDGTPKGDALIVF 165

  Fly   340 IKVESVNLALKILDEYNLR---GHKIRVQRAQFQMRGE------YNPALKPKRKKKDKEKLQKMK 395
            .:.|||.||.::.|:...|   |.|:|||:|....:.|      ...|||.|..:..::::|::.
pombe   166 FRSESVELAEQLFDDTEFRYGSGQKMRVQKANIDYKKEKTVNKDVGGALKKKALRLRQQQMQQIS 230

  Fly   396 EKLFDWRPDKLRGERSKN-EKTVIIKNLFTPELFEKEVELILEYQNNLREECSKCGMVRKVVIYD 459
            .  :|...:::..:|.|. .|.|::|::||.|..:|..||:::.::::.||..|||.|..||:||
pombe   231 S--WDDVDEEVDDKRKKRFNKIVVLKHIFTLEELDKTPELLIDLKDDITEEAEKCGRVTNVVLYD 293

  Fly   460 RHPDGVAQINMASPEEADLVIQMMQGRYFGQRQLSAEAWDGKTKYK--------IEESAVEAHER 516
            :.||||..:..::.|||:..:::||||||..|.:.|..:|||.:::        .||...:..|:
pombe   294 KEPDGVVTVRFSNNEEAEACVRLMQGRYFDGRVVEASIYDGKVRFQKSGKHTLDDEEDEEKRLEK 358

  Fly   517 LSKWDE 522
            .:.|.|
pombe   359 FADWLE 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
barc	NP_649313.1	RRM1_TatSF1_like	283..373	CDD:240727	34/92 (37%)
barc	NP_649313.1	RRM2_TatSF1_like	414..504	CDD:240728	37/89 (42%)
uap2	NP_596826.1	RRM	1..>220	CDD:223796	67/248 (27%)
		RRM1_TatSF1_like	109..202	CDD:240727	34/92 (37%)
		RRM3_RBM39_like	249..333	CDD:240731	34/83 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	59	1.000	Domainoid score	I3072
eggNOG	1	0.900	-	-		E1_KOG1548
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	159	1.000	Inparanoid score	I1258
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005218
OrthoInspector	1	1.000	-	-		oto101696
orthoMCL	1	0.900	-	-		OOG6_102631
Panther	1	1.100	-	-	LDO	PTHR15608
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1576
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.850