DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment barc and cus-2

DIOPT Version :9

Sequence 1:	NP_649313.1	Gene:	barc / 40369	FlyBaseID:	FBgn0037081	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_490765.1	Gene:	cus-2 / 171656	WormBaseID:	WBGene00022025	Length:	442	Species:	Caenorhabditis elegans

Alignment Length:	518	Identity:	165/518 - (31%)
Similarity:	274/518 - (52%)	Gaps:	93/518 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 VPEVDDKPTENKPQSDNH-----ADKTDETPSQDFAAYEEHMTYGADGGAI-YTDPSTKQKYKWC 98
            |||.::...|::...:.|     |...|::.|:.|...:.:..||.||..: :.|
Worm     5 VPETEENEEESQKIDEIHEIPAQAIIIDQSFSRRFLNNKWYGKYGEDGDLLEHID---------- 59

  Fly    99 ATGNNWQPLGVDEDVDGQAEDPYENEHYKWCPKSQQWLPKKQETET--EHYKWDDEQKKWVPKHP 161
               .:|:|:|:|| |:.               .||.|..::.:.:.  .||.||:|:|:||||
Worm    60 ---EDWEPVGLDE-VEF---------------LSQLWFEQEDQEKKAHRHYDWDEEKKEWVPK-- 103

  Fly   162 NPGQEGVCGVDEHGERTYTDKDGVEFFWDATKSAWFPKIDDDFMARYQMNYGF-IDNTSAGEKEK 225
             ..||                                ::::||:|.||.|||. .|:......|:
Worm   104 -AKQE--------------------------------EVNEDFIAEYQANYGVQYDDIYKKMDEE 135

  Fly   226 AEKEAAEAKRKEEELKRMTAEAEAAMSRDNPASSAAVPTGKRKAQEPPKWFEMDPLQNTKVYVSN 290
            .:::||:|::::||.|....:.:..:.....|...              |.::....:. |||||
Worm   136 LQEKAAKAQKEDEEKKEKKRKKKVGLGAGEDAKEG--------------WLDLGDKVHA-VYVSN 185

  Fly   291 LPLDITMDEFADLMGKCGMVMRDPQTQKFKLKLYAEKDGQIKGDGLCDYIKVESVNLALKILDEY 355
            ||.|||.:||...|.|||::..|.:|.|.|.|||.|::|::||||.|.|||.|||.||..|||..
Worm   186 LPEDITDEEFQKFMSKCGVIQPDIRTNKPKCKLYREENGKLKGDGRCCYIKKESVELACNILDGA 250

  Fly   356 NLRGHKIRVQRAQFQMRGEYNPALKPKRK--KKDKEKLQKMKEKLFDWRPDKLRGERSKNEKTVI 418
            ||.|.:::|:.|:|:|:|:::||.| :||  ...|::..:.:.|:|:|.|||.|..|.|::.|||
Worm   251 NLNGREVKVEEARFEMKGDFDPARK-RRKLTAAQKKRYMEQQNKIFEWTPDKPRNYRPKSDCTVI 314

  Fly   419 IKNLFTPELFEKEVELILEYQNNLREECSKCGMVRKVVIYDRHPDGVAQINMASPEEADLVIQMM 483
            :|||||.|:..|...|:|:.:..:.:.|.|.|:|:|||:|..|||||..:...:.||:|:.::.:
Worm   315 VKNLFTQEMMNKNAALMLDLKEEMTQSCQKYGIVKKVVVYANHPDGVVSVTFPTTEESDMAVKYL 379

  Fly   484 QGRYFGQRQLSAEAWDGKTKYKIEESAVEAHERLSKWDEFL--AEEETDKKASEDMKEEDVDS 544
            .||....|:|:||.|||:||:|:||:..:..:|..::::::  ...||.:::.:|..:|..|:
Worm   380 HGRVVDGRKLTAELWDGRTKFKVEETEEDEEKRRKEYEKYIEGGSSETKEESDDDDDDEAEDN 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
barc	NP_649313.1	RRM1_TatSF1_like	283..373	CDD:240727	48/89 (54%)
barc	NP_649313.1	RRM2_TatSF1_like	414..504	CDD:240728	38/89 (43%)
cus-2	NP_490765.1	RRS1	<93..142	CDD:295203	21/83 (25%)
		RRM1_TatSF1_like	179..268	CDD:240727	48/89 (54%)
		RRM2_TatSF1_like	310..400	CDD:240728	38/89 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165173
Domainoid	1	1.000	52	1.000	Domainoid score	I7702
eggNOG	1	0.900	-	-		E1_KOG1548
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121866
Inparanoid	1	1.050	271	1.000	Inparanoid score	I1816
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1542889at2759
OrthoFinder	1	1.000	-	-		FOG0005218
OrthoInspector	1	1.000	-	-		oto19385
orthoMCL	1	0.900	-	-		OOG6_102631
Panther	1	1.100	-	-	LDO	PTHR15608
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1576
SonicParanoid	1	1.000	-	-		X5592
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790