DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rgn and Clec7a

DIOPT Version :9

Sequence 1:	NP_001246866.1	Gene:	rgn / 40368	FlyBaseID:	FBgn0261258	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_064392.2	Gene:	Clec7a / 56644	MGIID:	1861431	Length:	244	Species:	Mus musculus

Alignment Length:	215	Identity:	46/215 - (21%)
Similarity:	74/215 - (34%)	Gaps:	45/215 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CCQVFILALFAHTIAVEFHGSAARAE--INF----------------EGPSPAHSQDTAAPTSRP 55
            |..|.::|.....:|...|.|....|  .||                |..:|:.:..|....|:|
Mouse    54 CFVVVVVAAVLGALAFWRHNSGRNPEEKDNFLSRNKENHKPTESSLDEKVAPSKASQTTGGFSQP 118

  Fly    56 KRRVYALCPPKFHRVGTDCYSLVDQRSSWLEAHFFCKDKNANLTEPGKHADRKLRLFLQKQDALS 120
                   |.|.:...|..||......:||..:...|....|:|.   |..:.|...|::.|.: |
Mouse   119 -------CLPNWIMHGKSCYLFSFSGNSWYGSKRHCSQLGAHLL---KIDNSKEFEFIESQTS-S 172

  Fly   121 GENDPIWLGATYDHHNNRWQWSMSGRNLSTDSFSRTDSAYVQLISNSQP---LDNNCAIYDPSLK 182
            ...:..|:|.:.:.....|.|. .|.....:||.         :.|:.|   |.:||.....|..
Mouse   173 HRINAFWIGLSRNQSEGPWFWE-DGSAFFPNSFQ---------VRNTAPQESLLHNCVWIHGSEV 227

  Fly   183 YRWSARPCSDKLRFICQHKM 202
            |.   :.|:.....||:.::
Mouse   228 YN---QICNTSSYSICEKEL 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgn	NP_001246866.1	CLECT	74..200	CDD:153057	29/128 (23%)
		GBP_C	<414..508	CDD:303769
		TPH	421..756	CDD:290579
		coiled coil	483..494	CDD:293879
Clec7a	NP_064392.2	ITAM-like	15..18
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..41
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..113		8/41 (20%)
		CLECT_NK_receptors_like	119..242	CDD:153063	32/139 (23%)
		(1,3-beta-D-glucosyl)n binding. /evidence=ECO:0000305\|PubMed:17473009, ECO:0007744\|PDB:2CL8	145..152		1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841919
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930