DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rgn and MRC1

DIOPT Version :9

Sequence 1:	NP_001246866.1	Gene:	rgn / 40368	FlyBaseID:	FBgn0261258	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_002429.1	Gene:	MRC1 / 4360	HGNCID:	7228	Length:	1456	Species:	Homo sapiens

Alignment Length:	156	Identity:	35/156 - (22%)
Similarity:	62/156 - (39%)	Gaps:	32/156 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PPK------FHRVGTDCYSLVDQRSSWLEAHFFCKDKN---ANLTEPGKHADRKLRLFLQKQDAL 119
            ||.      |.:.|...|||:.|:..|.||..:||..|   |::.:|..:|...|:        :
Human  1090 PPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQ--------M 1146

  Fly   120 SGENDPIWLGATYDHHNNRWQWSMSGRNLSTDSFSRTDSAYVQLISNSQPLDNNCAIYDPSLKYR 184
            ...|:.:|:....:..:|::.|        ||.:.   ..|....::...|.:.|...|  |...
Human  1147 ETSNERVWIALNSNLTDNQYTW--------TDKWR---VRYTNWAADEPKLKSACVYLD--LDGY 1198

  Fly   185 WSARPCSDKLRFICQH--KMPKVSGP 208
            |....|::...|:|:.  ::|....|
Human  1199 WKTAHCNESFYFLCKRSDEIPATEPP 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgn	NP_001246866.1	CLECT	74..200	CDD:153057	29/128 (23%)
		GBP_C	<414..508	CDD:303769
		TPH	421..756	CDD:290579
		coiled coil	483..494	CDD:293879
MRC1	NP_002429.1	RICIN	27..142	CDD:214672
		RICIN	34..141	CDD:238092
		FN2	161..209	CDD:128373
		CLECT	234..342	CDD:153057
		CLECT	362..487	CDD:214480
		CLECT	504..626	CDD:214480
		CLECT	659..779	CDD:153057
		CLECT	802..923	CDD:214480
		CLECT	945..1080	CDD:214480
		CLECT	1097..1213	CDD:214480	30/136 (22%)
		CLECT	1230..1356	CDD:214480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910