DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rgn and KLRC1

DIOPT Version :9

Sequence 1:	NP_001246866.1	Gene:	rgn / 40368	FlyBaseID:	FBgn0261258	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_002250.2	Gene:	KLRC1 / 3821	HGNCID:	6374	Length:	233	Species:	Homo sapiens

Alignment Length:	151	Identity:	33/151 - (21%)
Similarity:	59/151 - (39%)	Gaps:	25/151 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TSRPKRRVYALCPPKFHRVGTDCYSLVDQRSSWLEAHFFCKDKNANLTEPGKHADRKLRLFLQKQ 116
            |...|.|....||.::......||.:..:|.:|.|:...|..||::|.......:.|.
Human   108 TRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKF------- 165

  Fly   117 DALSGENDPIWLGATYDHHNNRWQWSMSGRNLSTDSFSRTDSAYVQLISNSQPLDNNCAIYDPSL 181
              ||..:...|:|...:..::.|. :|:|            .|:...|.:|...:.|||:...:
Human   166 --LSIISPSSWIGVFRNSSHHPWV-TMNG------------LAFKHEIKDSDNAELNCAVLQVN- 214

  Fly   182 KYRWSARPCSDKLRFICQHKM 202
              |..:..|...:.:.|:||:
Human   215 --RLKSAQCGSSIIYHCKHKL 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgn	NP_001246866.1	CLECT	74..200	CDD:153057	26/125 (21%)
		GBP_C	<414..508	CDD:303769
		TPH	421..756	CDD:290579
		coiled coil	483..494	CDD:293879
KLRC1	NP_002250.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Immunoreceptor tyrosine-based inhibition motif (ITIM). /evidence=ECO:0000269\|PubMed:12165520	6..11
		Immunoreceptor tyrosine-based inhibition motif (ITIM). /evidence=ECO:0000269\|PubMed:12165520	38..43
		CLECT_NK_receptors_like	119..231	CDD:153063	28/136 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151801
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930