DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rgn and KLRB1

DIOPT Version :9

Sequence 1:	NP_001246866.1	Gene:	rgn / 40368	FlyBaseID:	FBgn0261258	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_002249.1	Gene:	KLRB1 / 3820	HGNCID:	6373	Length:	225	Species:	Homo sapiens

Alignment Length:	217	Identity:	49/217 - (22%)
Similarity:	82/217 - (37%)	Gaps:	44/217 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KMWCCQVFILALFAHTIAVEFHGSAARAEINFEGPSPAHSQDTAAPTSRPKRRVYALCPPKFHRV 70
            |:.|..:.:|.|....::|.......::.|  |..|....|.....|.||.   ...||..:.::
Human    42 KLSCAGIILLVLVVTGLSVSVTSLIQKSSI--EKCSVDIQQSRNKTTERPG---LLNCPIYWQQL 101

  Fly    71 GTDCYSLVDQRSSWLEAHFFCKDKNANLTEPGKHADRKLRLFLQKQDALSGENDPI-------WL 128
            ...|.......:.|..:...|..|.::|            |.::.:|.|....:.|       |:
Human   102 REKCLLFSHTVNPWNNSLADCSTKESSL------------LLIRDKDELIHTQNLIRDKAILFWI 154

  Fly   129 GATYDHHNNRWQWSMSGRNL-STDSFSRTDSAYVQLISNSQPLDNNCAIYDPSLKYRWSARPCSD 192
            |..:......|:| ::|..| |.|...|.|:.....||.||     .::|.   :|      ||.
Human   155 GLNFSLSEKNWKW-INGSFLNSNDLEIRGDAKENSCISISQ-----TSVYS---EY------CST 204

  Fly   193 KLRFICQHKMPKVSGPNRYKIY 214
            ::|:|||.::.    |.|.|:|
Human   205 EIRWICQKELT----PVRNKVY 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rgn	NP_001246866.1	CLECT	74..200	CDD:153057	30/133 (23%)
		GBP_C	<414..508	CDD:303769
		TPH	421..756	CDD:290579
		coiled coil	483..494	CDD:293879
KLRB1	NP_002249.1	CLECT_NK_receptors_like	94..212	CDD:153063	32/144 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151795
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930