DRSC/TRiP Functional Genomics Resources

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Protein Alignment rgn and unc-89

DIOPT Version :10

Sequence 1:NP_001246866.1 Gene:rgn / 40368 FlyBaseID:FBgn0261258 Length:808 Species:Drosophila melanogaster
Sequence 2:NP_001020985.1 Gene:unc-89 / 171990 WormBaseID:WBGene00006820 Length:8081 Species:Caenorhabditis elegans


Alignment Length:594 Identity:113/594 - (19%)
Similarity:249/594 - (41%) Gaps:79/594 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   245 RRVK--AEDSDEEMIIPDRRRNNNRRNNHRNRQIKNQNQHPNDVNYQPAQQRQRNRPRTSTVAPT 307
            |||.  .|:..:|:|..||::..:...:.:.:..:...:.|.....:..::.:..:.: |..:||
 Worm  1353 RRVSFAEEELPKEVIDSDRKKKKSPSPDKKEKSPEKTEEKPASPTKKTGEEVKSPKEK-SPASPT 1416

  Fly   308 TTQSVSQSNDVLAP--------SPTPQQMTQYDRKLQRQRERERRRQLRRQERQKLAREQKRERQ 364
            ..:....:.:|.:|        |||.::.:......:...|.:.:...:...:::.:.|:..:.:
 Worm  1417 KKEKSPAAEEVKSPTKKEKSPSSPTKKEKSPSSPTKKTGDEVKEKSPPKSPTKKEKSPEKPEDVK 1481

  Fly   365 RRLKEERQ-------------RLQREEQQRRQRLHH--DEPKPQVNPQVKPQVIDELRQRSGEDL 414
            ..:|:|:.             .:::.|......:.|  :|.:..|..:..|:.:|| :.:|....
 Worm  1482 SPVKKEKSPDATNIVEVSSETTIEKTETTMTTEMTHESEESRTSVKKEKTPEKVDE-KPKSPTKK 1545

  Fly   415 DKNQ----TDEHEQKLRNEQEKKLREEQQKQRDEQEQKDREEQDRLKQEEEQARTHQKELKENQE 475
            ||:.    |:|.:..::.|:..:..||:.....::|:...:.....|:.|.:.::..|:.|..::
 Worm  1546 DKSPEKSITEEIKSPVKKEKSPEKVEEKPASPTKKEKSPEKPASPTKKSENEVKSPTKKEKSPEK 1610

  Fly   476 QQLRELKAKQEREKQERDYQQQKREHELELLKQRQAEADRQHAADEEAEKLRLERIQKQRELEAQ 540
            ..:.|||:.:|:..::.| .:.|...:.|...::.|..|.:....:|...      :|..|....
 Worm  1611 SVVEELKSPKEKSPEKAD-DKPKSPTKKEKSPEKSATEDVKSPTKKEKSP------EKVEEKPTS 1668

  Fly   541 QRREREEQRRKQREEQEEQDRQNHAKRLAEEKRLHDLYAERIRLANTEREKQLAEAHEAKRLEEL 605
            ..::.....:|..:|.:...::..:.:..|||          ..:.|::||    :.|...:||:
 Worm  1669 PTKKESSPTKKTDDEVKSPTKKEKSPQTVEEK----------PASPTKKEK----SPEKSVVEEV 1719

  Fly   606 KLQEQLKKQEDERQEQIRREQEEEEKRLELERLEEARRFEEKELKRLHEENQRREEQKLQREREI 670
            |   ..|::..|:.|:..:...::||..|....||.:...:||        :..|:...::.:..
 Worm  1720 K---SPKEKSPEKAEEKPKSPTKKEKSPEKSAAEEVKSPTKKE--------KSPEKSAEEKPKSP 1773

  Fly   671 ALREAAEKKLAEEEEMLRKEVAEEERKVKQRLEDEMRQAEEARKAKEAEERAAEEAKAAEQKRRV 735
            ..:|::..|:|::      ||....:|.|...:.|.:.|...:|.|..|:.||||.|:..:|.:.
 Worm  1774 TKKESSPVKMADD------EVKSPTKKEKSPEKVEEKPASPTKKEKTPEKSAAEELKSPTKKEKS 1832

  Fly   736 EAA-KKKADEEVKAKLEEKRREYVTRISALSPEDQKKFIEMRKRRKQLK---EKKERDQRAKELK 796
            .:: .||..:|.|.|..||..|     ...||..:|......|::|...   ||....:..::||
 Worm  1833 PSSPTKKTGDESKEKSPEKPEE-----KPKSPTPKKSPPGSPKKKKSKSPEAEKPPAPKLTRDLK 1892

  Fly   797 RIQQAMRLD 805
             :|...:.|
 Worm  1893 -LQTVNKTD 1900

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rgnNP_001246866.1 CLECT 74..200 CDD:153057
Smc <405..>673 CDD:440809 49/271 (18%)
CCDC47 <732..783 CDD:480722 14/51 (27%)
unc-89NP_001020985.1 SH3 65..124 CDD:473055
RhoGEF 153..328 CDD:238091
PH_unc89 341..455 CDD:270134
Ig strand B 565..569 CDD:409405
I-set <570..638 CDD:400151
Ig strand C 578..582 CDD:409405
Ig strand E 604..608 CDD:409405
Ig strand F 618..623 CDD:409405
Ig strand G 631..634 CDD:409405
I-set 648..737 CDD:400151
Ig strand B 665..669 CDD:409353
Ig strand C 678..682 CDD:409353
Ig strand E 703..707 CDD:409353
Ig strand F 717..722 CDD:409353
Ig strand G 730..733 CDD:409353
I-set 748..837 CDD:400151
Ig strand B 765..769 CDD:409353
Ig strand C 778..782 CDD:409353
Ig strand E 803..807 CDD:409353
Ig strand F 817..822 CDD:409353
Ig strand G 830..833 CDD:409353
Ig 844..935 CDD:472250
Ig strand B 861..865 CDD:409405
Ig strand C 874..878 CDD:409405
Ig strand E 900..904 CDD:409405
Ig strand F 915..920 CDD:409405
Ig strand G 928..931 CDD:409405
Ig 946..1034 CDD:472250
Ig strand B 963..967 CDD:409543
Ig strand C 976..980 CDD:409543
Ig strand E 1002..1006 CDD:409543
Ig strand F 1010..1019 CDD:409543
Ig strand G 1027..1030 CDD:409543
I-set 1044..1133 CDD:400151
Ig strand B 1061..1065 CDD:409353
Ig strand C 1074..1078 CDD:409353
Ig strand E 1099..1103 CDD:409353
Ig strand F 1113..1118 CDD:409353
Ig strand G 1126..1129 CDD:409353
Ig 1140..1237 CDD:472250
Ig strand B 1157..1161 CDD:409543
Ig strand C 1170..1174 CDD:409543
Ig strand E 1200..1204 CDD:409543
Ig strand F 1208..1222 CDD:409543
Ig strand G 1230..1233 CDD:409543
PTZ00121 <1304..1992 CDD:173412 113/594 (19%)
Ig 1982..2068 CDD:472250
Ig strand B 1999..2003 CDD:409353
Ig strand C 2010..2014 CDD:409353
Ig strand E 2036..2040 CDD:409353
Ig strand F 2048..2053 CDD:409353
Ig strand G 2061..2064 CDD:409353
I-set 2081..2164 CDD:400151
Ig strand B 2092..2096 CDD:409406
Ig strand C 2105..2109 CDD:409406
Ig strand E 2130..2134 CDD:409406
Ig strand F 2144..2149 CDD:409406
Ig strand G 2157..2160 CDD:409406
Ig 2171..2262 CDD:472250
Ig strand B 2188..2192 CDD:409353
Ig strand C 2202..2206 CDD:409353
Ig strand E 2226..2232 CDD:409353
Ig strand F 2242..2247 CDD:409353
Ig strand G 2255..2258 CDD:409353
I-set 2269..2360 CDD:400151
Ig strand B 2286..2290 CDD:409405
Ig strand C 2299..2303 CDD:409405
Ig strand E 2326..2330 CDD:409405
Ig strand F 2340..2345 CDD:409405
Ig strand G 2353..2356 CDD:409405
I-set 2367..2456 CDD:400151
Ig strand B 2384..2388 CDD:409543
Ig strand C 2397..2401 CDD:409543
Ig strand E 2422..2426 CDD:409543
Ig strand F 2436..2441 CDD:409543
Ig strand G 2449..2452 CDD:409543
Ig 2463..2554 CDD:472250
Ig strand B 2480..2484 CDD:409405
Ig strand C 2494..2498 CDD:409405
Ig strand E 2520..2524 CDD:409405
Ig strand F 2534..2539 CDD:409405
Ig strand G 2547..2550 CDD:409405
Ig 2563..2652 CDD:472250
Ig strand C 2593..2597 CDD:409405
Ig strand E 2618..2622 CDD:409405
Ig strand F 2632..2637 CDD:409405
Ig strand G 2645..2648 CDD:409405
I-set 2659..2747 CDD:400151
Ig strand B 2675..2679 CDD:409543
Ig strand C 2688..2692 CDD:409543
Ig strand E 2713..2717 CDD:409543
Ig strand F 2727..2732 CDD:409543
Ig strand G 2740..2743 CDD:409543
Ig 2754..2843 CDD:472250
Ig strand C 2784..2788 CDD:409353
Ig strand E 2809..2813 CDD:409353
Ig strand F 2824..2829 CDD:409353
Ig strand G 2837..2840 CDD:409353
I-set 2887..2981 CDD:400151
Ig strand B 2904..2908 CDD:409405
Ig strand C 2917..2921 CDD:409405
Ig strand E 2947..2951 CDD:409405
Ig strand F 2961..2966 CDD:409405
Ig strand G 2974..2977 CDD:409405
I-set 2994..3082 CDD:400151
Ig strand B 3011..3015 CDD:409353
Ig strand C 3024..3028 CDD:409353
Ig strand E 3046..3052 CDD:409353
Ig strand F 3062..3067 CDD:409353
Ig strand G 3075..3078 CDD:409353
Ig 3087..3183 CDD:472250
Ig strand B 3104..3108 CDD:409543
Ig strand C 3117..3121 CDD:409543
Ig strand E 3149..3154 CDD:409543
Ig strand F 3164..3169 CDD:409543
I-set 3189..3279 CDD:400151
Ig strand B 3206..3210 CDD:409405
Ig strand C 3218..3222 CDD:409405
Ig strand E 3245..3249 CDD:409405
Ig strand F 3259..3264 CDD:409405
Ig strand G 3272..3275 CDD:409405
I-set 3286..3377 CDD:400151
Ig strand B 3303..3307 CDD:409353
Ig strand C 3316..3320 CDD:409353
Ig strand E 3343..3347 CDD:409353
Ig strand F 3357..3362 CDD:409353
Ig strand G 3370..3373 CDD:409353
I-set 3384..3472 CDD:400151
Ig strand B 3401..3405 CDD:409405
Ig strand C 3414..3418 CDD:409405
Ig strand E 3441..3445 CDD:409405
Ig strand F 3455..3460 CDD:409405
Ig strand G 3468..3471 CDD:409405
I-set 3482..3573 CDD:400151
Ig strand B 3499..3503 CDD:409353
Ig strand C 3512..3516 CDD:409353
Ig strand E 3539..3543 CDD:409353
Ig strand F 3553..3558 CDD:409353
Ig strand G 3566..3569 CDD:409353
I-set 3580..3671 CDD:400151
Ig strand B 3597..3601 CDD:409405
Ig strand C 3610..3614 CDD:409405
Ig strand E 3637..3641 CDD:409405
Ig strand F 3651..3656 CDD:409405
Ig strand G 3664..3667 CDD:409405
I-set 3686..3776 CDD:400151
Ig strand B 3703..3707 CDD:409353
Ig strand C 3716..3720 CDD:409353
Ig strand E 3742..3746 CDD:409353
Ig strand F 3756..3761 CDD:409353
Ig strand G 3769..3772 CDD:409353
I-set 3817..3902 CDD:400151
Ig strand B 3834..3838 CDD:409543
Ig strand C 3847..3851 CDD:409543
Ig strand E 3873..3877 CDD:409543
Ig strand F 3887..3892 CDD:409543
Ig strand G 3900..3903 CDD:409543
I-set 3920..4010 CDD:400151
Ig strand B 3937..3941 CDD:409353
Ig strand C 3950..3954 CDD:409353
Ig strand E 3974..3980 CDD:409353
Ig strand F 3990..3995 CDD:409353
Ig strand G 4003..4006 CDD:409353
I-set 4018..4107 CDD:400151
Ig strand B 4035..4039 CDD:409353
Ig strand C 4047..4051 CDD:409353
Ig strand E 4073..4077 CDD:409353
Ig strand F 4087..4092 CDD:409353
Ig strand G 4100..4103 CDD:409353
Ig 4114..4202 CDD:472250
Ig strand B 4130..4134 CDD:409353
Ig strand C 4142..4146 CDD:409353
Ig strand F 4182..4187 CDD:409353
Ig strand G 4195..4198 CDD:409353
Ig 4212..4298 CDD:472250
Ig strand B 4229..4233 CDD:409543
Ig strand C 4241..4245 CDD:409543
Ig strand E 4264..4268 CDD:409543
Ig strand F 4278..4283 CDD:409543
Ig strand G 4291..4294 CDD:409543
I-set 4302..4388 CDD:400151
Ig strand B 4319..4323 CDD:409543
Ig strand C 4331..4335 CDD:409543
Ig strand E 4354..4358 CDD:409543
Ig strand F 4368..4373 CDD:409543
Ig strand G 4381..4384 CDD:409543
I-set 4400..4486 CDD:400151
Ig strand B 4417..4421 CDD:409543
Ig strand C 4429..4433 CDD:409543
Ig strand E 4452..4456 CDD:409543
Ig strand F 4466..4471 CDD:409543
Ig strand G 4479..4482 CDD:409543
Ig 4493..4582 CDD:472250
Ig strand B 4508..4512 CDD:409543
Ig strand C 4520..4524 CDD:409543
Ig strand E 4546..4550 CDD:409543
Ig strand F 4560..4565 CDD:409543
Ig strand G 4574..4577 CDD:409543
Ig 4588..4679 CDD:472250
Ig strand B 4605..4609 CDD:409543
Ig strand C 4617..4621 CDD:409543
Ig strand E 4645..4649 CDD:409543
Ig strand F 4659..4664 CDD:409543
Ig strand G 4672..4675 CDD:409543
I-set 4685..4772 CDD:400151
Ig strand B 4700..4704 CDD:409543
Ig strand C 4712..4716 CDD:409543
Ig strand E 4738..4742 CDD:409543
Ig strand F 4752..4757 CDD:409543
Ig strand G 4765..4768 CDD:409543
Ig 4781..4869 CDD:472250
Ig strand B 4797..4801 CDD:409353
Ig strand C 4810..4813 CDD:409353
Ig strand E 4835..4839 CDD:409353
Ig strand F 4849..4854 CDD:409353
Ig strand G 4862..4865 CDD:409353
Ig 4873..4962 CDD:472250
Ig strand B 4890..4894 CDD:409543
Ig strand C 4902..4906 CDD:409543
Ig strand E 4928..4932 CDD:409543
Ig strand F 4942..4947 CDD:409543
Ig strand G 4955..4958 CDD:409543
Ig 4979..5060 CDD:472250
Ig strand B 4985..4989 CDD:409543
Ig strand C 4997..5001 CDD:409543
Ig strand E 5025..5029 CDD:409543
Ig strand F 5039..5044 CDD:409543
Ig strand G 5052..5055 CDD:409543
I-set 5073..5161 CDD:400151
Ig strand B 5088..5092 CDD:409353
Ig strand C 5101..5105 CDD:409353
Ig strand E 5127..5131 CDD:409353
Ig strand F 5141..5146 CDD:409353
Ig strand G 5154..5157 CDD:409353
I-set 5171..5260 CDD:400151
Ig strand B 5188..5192 CDD:409405
Ig strand C 5201..5205 CDD:409405
Ig strand E 5227..5231 CDD:409405
Ig strand F 5241..5246 CDD:409405
Ig strand G 5256..5259 CDD:409405
Ig 5277..5367 CDD:472250
Ig strand B 5294..5298 CDD:409353
Ig strand C 5307..5311 CDD:409353
Ig strand E 5333..5337 CDD:409353
Ig strand F 5347..5352 CDD:409353
Ig strand G 5360..5363 CDD:409353
I-set 5383..5473 CDD:400151
Ig strand B 5400..5404 CDD:409353
Ig strand C 5413..5417 CDD:409353
Ig strand E 5439..5443 CDD:409353
Ig strand F 5453..5458 CDD:409353
Ig strand G 5466..5469 CDD:409353
I-set 5487..5577 CDD:400151
Ig strand B 5504..5508 CDD:409353
Ig strand C 5517..5521 CDD:409353
Ig strand E 5543..5547 CDD:409353
Ig strand F 5557..5562 CDD:409353
Ig strand G 5571..5574 CDD:409353
I-set 5595..5684 CDD:400151
Ig strand C 5625..5629 CDD:409353
Ig strand E 5650..5656 CDD:409353
Ig strand F 5666..5671 CDD:409353
Ig strand G 5680..5683 CDD:409353
I-set 5701..5791 CDD:400151
Ig strand B 5718..5722 CDD:409405
Ig strand C 5731..5735 CDD:409405
Ig strand E 5757..5761 CDD:409405
Ig strand F 5771..5776 CDD:409405
Ig 5815..5905 CDD:472250
Ig strand B 5832..5836 CDD:409543
Ig strand C 5845..5849 CDD:409543
Ig strand E 5871..5875 CDD:409543
Ig strand F 5885..5890 CDD:409543
Ig strand G 5898..5901 CDD:409543
I-set 5925..6015 CDD:400151
Ig strand B 5942..5946 CDD:409405
Ig strand C 5955..5959 CDD:409405
Ig strand E 5981..5985 CDD:409405
Ig strand F 5995..6000 CDD:409405
Ig strand G 6008..6011 CDD:409405
I-set 6038..6131 CDD:400151
Ig strand B 6055..6059 CDD:409353
Ig strand C 6068..6072 CDD:409353
Ig strand E 6097..6101 CDD:409353
Ig strand F 6111..6116 CDD:409353
Ig strand G 6124..6127 CDD:409353
Ig 6150..6240 CDD:472250
Ig strand B 6167..6171 CDD:409405
Ig strand C 6180..6184 CDD:409405
Ig strand E 6206..6210 CDD:409405
Ig strand F 6220..6225 CDD:409405
Ig strand G 6233..6236 CDD:409405
FN3 6275..6358 CDD:214495
Ig <6433..6495 CDD:472250
Ig strand C 6440..6444 CDD:409543
Ig strand E 6469..6473 CDD:409543
Ig strand F 6483..6488 CDD:409543
IgI_telokin-like 6510..6597 CDD:409565
Ig strand A 6510..6513 CDD:409565
Ig strand A' 6515..6518 CDD:409565
Ig strand B 6522..6531 CDD:409565
Ig strand C 6536..6542 CDD:409565
Ig strand C' 6545..6547 CDD:409565
Ig strand D 6553..6558 CDD:409565
Ig strand E 6561..6569 CDD:409565
Ig strand F 6577..6584 CDD:409565
Ig strand G 6587..6597 CDD:409565
PK_Unc-89_rpt1 6620..6878 CDD:271011
I-set 7528..7616 CDD:400151
Ig strand B 7545..7549 CDD:409405
Ig strand C 7558..7562 CDD:409405
Ig strand E 7583..7587 CDD:409405
Ig strand F 7597..7602 CDD:409405
Ig strand G 7610..7613 CDD:409405
FN3 7621..7716 CDD:238020
STKc_Unc-89_rpt2 7781..8035 CDD:271014
Blue background indicates that the domain is not in the aligned region.

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