Protein Alignment ebd2 and JRKL

DIOPT Version :10

• Sequence 1: NP_649307.1
• Gene: ebd2 / 40363
• FlyBaseID: FBgn0037076
• Length: 367
• Species: Drosophila melanogaster
• Sequence 2: NP_003763.2
• Gene: JRKL / 8690
• HGNCID: 6200
• Length: 524
• Species: Homo sapiens
• Alignment Length: 359
• Identity: 75/359 - (20%)
• Similarity: 139/359 - (38%)
• Gaps: 73/359 - (20%)

  Fly    25 SRRNERNILTFYEKIAVIRYYDETNISRNSLAKMFHCCATQIRRILDKKKDLLQQLATLSEADAS 89
            |.:.:|.:||..:|:.:|:..::...|: .||.::....|.:|.|...|:.:   :...|.:|::
Human     2 SGKRKRVVLTIKDKLDIIKKLEDGGSSK-QLAVIYGIGETTVRDIRKNKEKI---ITYASSSDST 62

  Fly    90 IIIEEMTRKRRKFEMSAISFLLHEWVERCIQMQLNISIRNQKLKETAIR----------MAAVLN 144
            .::    .||:..:.|     ::|.::|.:....|    .|:.|...|.          ....|.
Human    63 SLL----AKRKSMKPS-----MYEELDRAMLEWFN----QQRAKGNPISGPICAKRAEFFFYALG 114

  Fly   145 LP-SFRPSYRWLSRFRNKYKYEADELGYQGENPLNQDLPVEDIIVEFKHALPNFMQRELDNPGEA 208
            :. .|.||..||:||  |.::...|:..:.|.....:..|||....|:    :|::||...|.:.
Human   115 MDGDFNPSAGWLTRF--KQRHSIREINIRNERLNGDETAVEDFCNNFR----DFIERENLQPEQI 173

  Fly   209 ISKAAVMADFVNLSSENSIMS------DHPEGDNEVELVTCEPTMMSSPSSTPDAAEG--EIPLQ 265
            .:.......:..|.|..|::.      .|...:..|.::.|.            .|.|  ::.|.
Human   174 YNADETGLFWKCLPSRISVIKGKCTVPGHKSIEERVTIMCCA------------NATGLHKLKLC 226

  Fly   266 AHGDQENP-----DDQINAGTSTL-LNGVFPHLAIIHQFALMNSDVQALELISQLGVHMQQQAV- 323
            ..|..:.|     .|.:|...|.. ..|.:..|:|..|:.......|..|.:...|  :|::||
Human   227 VVGKAKKPRSFKSTDTLNLPVSYFSQKGAWMDLSIFRQWFDKIFVPQVREYLRSKG--LQEKAVL 289

  Fly   324 ----SGAYHNLSLATTDGDGQDDPGEIALSELPP 353
                |..:.|.::.      :.|.|:|....|||
Human   290 LLDNSPTHPNENVL------RSDDGQIFAKYLPP 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ebd2	NP_649307.1	CENP-B_N	27..80	CDD:461229	12/52 (23%)
		CENPB	101..166	CDD:197828	16/75 (21%)
JRKL	NP_003763.2	CENP-B_N	4..53	CDD:461229	12/52 (23%)
		CENPB	73..139	CDD:197828	17/76 (22%)
		DDE_1	206..385	CDD:367380	28/132 (21%)