Protein Alignment Tbc1d8-9 and TBC1D3F

DIOPT Version :10

• Sequence 1: NP_649305.1
• Gene: Tbc1d8-9 / 40361
• FlyBaseID: FBgn0037074
• Length: 1291
• Species: Drosophila melanogaster
• Sequence 2: NP_115634.3
• Gene: TBC1D3F / 84218
• HGNCID: 18257
• Length: 549
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 76/290 - (26%)
• Similarity: 124/290 - (42%)
• Gaps: 53/290 - (18%)

  Fly   387 DLLARVH----VPLSRERAKYDISWSKQTALMNTFKTQFSAEIIQKQE--EKMVRWEAHFRDFGR 445
            |.|..||    .||:...||                 |...||.:|.:  :.:..||.:
Human    47 DHLGIVHETELPPLTAREAK-----------------QIRREISRKSKWVDMLGDWEKY------ 88

  Fly   446 GIGMFRTTDVINLIVEGIPDKLRQEIWLIFSGAIHDKEMNPGLYEDLVEKAACIKNCFAH-DEID 509
                ..:..:|:...:|:|..:|..:|.:.......|..|||.|:.:.||.   |....| ..||
Human    89 ----KSSRKLIDRAYKGMPMNIRGPMWSVLLNIEEMKLKNPGRYQIMKEKG---KRSSEHIQRID 146

  Fly   510 RDLPRSLPEHPAFQSTDGIGALRR----VLQAYALRNPQVGYCQAMNIVSSVFLLFCDEENAFWM 570
            ||:..:|.:|..|:  |..|..:|    :|.||...||:||||:.::.::::|||:..||:|||.
Human   147 RDVSGTLRKHIFFR--DRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWA 209

  Fly   571 LASLC---ENLLPDYYKDK---VVGAQIDQGVLNELVETHLPDLHGHLEQLGVIKMIS-ISWFLT 628
            |..|.   .:.|..::...   |.|.|..|   ..:|.|..|...||.::..:....| :...:.
Human   210 LVQLLASERHSLQGFHSPNGGTVQGLQDQQ---EHVVATSQPKTMGHQDKKDLCGQCSPLGCLIR 271

  Fly   629 IFMSVISYESSLHILDCFFYEGAKIIFMIS 658
            |.:..||...:|.:.|.:..||.:.:..|:
Human   272 ILIDGISLGLTLRLWDVYLVEGEQALMPIT 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d8-9	NP_649305.1	PH-GRAM1_TCB1D8_TCB1D9_family	147..249	CDD:275404
		PH-GRAM2_TCB1D9_TCB1D9B	293..389	CDD:270161	1/1 (100%)
		TBC	462..670	CDD:214540	61/209 (29%)
TBC1D3F	NP_115634.3	TBC	99..312	CDD:214540	61/211 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..425
		PHA03381	<356..>468	CDD:177618