Protein Alignment Tbc1d8-9 and tbc1d2b

DIOPT Version :10

• Sequence 1: NP_649305.1
• Gene: Tbc1d8-9 / 40361
• FlyBaseID: FBgn0037074
• Length: 1291
• Species: Drosophila melanogaster
• Sequence 2: XP_012822167.2
• Gene: tbc1d2b / 734055
• XenbaseID: XB-GENE-5932742
• Length: 944
• Species: Xenopus tropicalis
• Alignment Length: 842
• Identity: 185/842 - (21%)
• Similarity: 323/842 - (38%)
• Gaps: 264/842 - (31%)

  Fly     8 LLLPS----AFWIAEMHSRYFVLQKRRGHGESRGFGSMLVGTYDSVMNTKPAPYRILHQTPSSEV 68
            |..||    .:|:.|:.      |||..:..|  ||::   ..:||:|  ||
 Frog   109 LRAPSRHAMTYWLQELQ------QKRWEYCNS--FGAL---KRESVIN--PA------------- 147

  Fly    69 SYEIAIGITQDEI--------VKDWEWLKANLF------KVLDEMENEDEVTNFTICKIQSLYTQ 119
            |.::.||:...|.        :.|.|..: |.|      .||.:..:.::.:| ....:|.|..|
 Frog   148 STKVPIGLVARESPDYMGIPNINDAERAR-NQFAVETCPSVLGDQTSAEQASN-NPAAVQVLLRQ 210

  Fly   120 NNQD--------DTGESADFKVMKSKFRQIFKMPEEERLVISYSATYVKNKIPRQGQLYISLNHV 176
            .:.|        ..|:|:|.:      :..|...||..|:         |..|:  :|..||.||
 Frog   211 WSNDIRSSMQHLRPGKSSDCR------KSTFYTNEEWELL---------NPTPK--ELEESLLHV 258

  Fly   177 ----------------CFYSYMLG---QEIKRIIRFAELEDISRNANTIYLKTTNNMTYNFTMLF 222
                            ..:.:..|   |..:|.:|  |:..:::|.......:           .
 Frog   259 EKRKPPTEGIKGSTAGMSFPFDFGRIPQRARRPLR--EIMGVNKNRTECLADS-----------L 310

  Fly   223 NASDAHLLIEQLNKMAIQQLIHDPDSPVVDHDTSNFSRLGSKTSKKPVLLRDLTARQKSEEFRIY 287
            ..||:.:..:.|.|:..|:              ....||......:..|:|.|....:|.::..|
 Frog   311 PVSDSRMESDVLLKLQSQE--------------EELERLKKDLLSQKELVRLLQQSLRSSQYDKY 361

  Fly   288 FRLPQSEIIDGKIKANIWTPYSK--------------RFNSGFIYLS-PNFFCFRSDVKDLVSVV 337
            |..|   ..||..|.::.....|              ......::.. ....|...::||.::::
 Frog   362 FASP---FCDGLSKEHLHLLQQKDTQIQELNHLLERQTLEKDHLHQEVEELKCSVKELKDQLNMM 423

  Fly   338 IPMKTIKSVEKKDDGQQRFENQI---------VIITSENVPF-------------MFAHIVDRAV 380
              |:||::   ||:...|...|:         ..:.:| :|.             :..:......
 Frog   424 --METIQA---KDEVIMRLSRQLSKYEQHTPSSTVAAE-IPVAPQLEELNRLQDSLQGYKAQNTF 482

  Fly   381 LISKITDLLARVHVPLSRER----------AKYDISWSKQTALMNTFKT-----------QFSAE 424
            |..:|.:|.|.......|||          ||.....||...|:...||           :|..:
 Frog   483 LNKEILELSALRRNAERREREMEARYSNLEAKMCQIESKYLVLLQEMKTPVCSDDQGTAREFVNQ 547

  Fly   425 IIQ------------------------------------KQEEKM-------------------- 433
            :::                                    ::|||:
 Frog   548 LLEDALKVENAEQPEHTFVKPHTVSKYDIHGFLIVPEDDEEEEKLVAKVRALDLKTLSLTENQEI 612

  Fly   434 ---VRWEAHF-----RDFGRGIGMFRTTDVINLIVEGIPDKLRQEIWLIFSGAIHDKEMN----P 486
               |:|:.:|     |:      |..:.::..|:..|||.:.|..:|..|:. :|.|::.    |
 Frog   613 SNVVKWDNYFASTVNRE------MACSPELKALVRNGIPHEHRSRMWKWFTN-LHIKKLKDEAAP 670

  Fly   487 GLYEDLVEKAACIKNCFAHDEIDRDLPRSLP--EHPAFQSTDGIGALRRVLQAYALRNPQVGYCQ 549
            |.::.|::.|...:|. |..:|:.||.|:||  :|....:::||..||.||.||:.|||.:||||
 Frog   671 GYFQSLLQNALEKQNP-ASKQIELDLMRTLPNNKHYTSPTSEGIQKLRNVLLAYSWRNPDIGYCQ 734

  Fly   550 AMNIVSSVFLLFCDEENAFWMLASLCENLLP-DYYKDKVVGAQIDQGVLNELVETHLPDLHGHLE 613
            .:|.::::.||:.|:|:|||.|.::.|..:| |||...::|:|:||.|..:|:...||.|..|.|
 Frog   735 GINRLAAIALLYLDQEDAFWCLVTIVEAFMPRDYYTKTLLGSQVDQRVFKDLMNEKLPRLCAHFE 799

  Fly   614 QLGV-IKMISISWFLTIFMSVISYESSLHILDCFFYEGAKIIFMISLQIIEWNRDKLLICQD 674
            |..| ..:|:.:|||.:|:..:..:....|.|...|||:|:||..:|.:.::..:::|..||
 Frog   800 QYKVDYTLITFNWFLVVFVDSVVSDILFRIWDSLLYEGSKVIFRFALGLFKYKEEEILKLQD 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d8-9	NP_649305.1	PH-GRAM1_TCB1D8_TCB1D9_family	147..249	CDD:275404	20/120 (17%)
		PH-GRAM2_TCB1D9_TCB1D9B	293..389	CDD:270161	18/132 (14%)
		TBC	462..670	CDD:214540	77/215 (36%)
tbc1d2b	XP_012822167.2	PH_TBC1D2A	34..134	CDD:269966	8/30 (27%)
		Smc	322..>560	CDD:440809	43/260 (17%)
		TBC	640..857	CDD:214540	77/218 (35%)