Protein Alignment Tbc1d8-9 and Tbc1d9

DIOPT Version :10

• Sequence 1: NP_649305.1
• Gene: Tbc1d8-9 / 40361
• FlyBaseID: FBgn0037074
• Length: 1291
• Species: Drosophila melanogaster
• Sequence 2: NP_001104774.1
• Gene: Tbc1d9 / 71310
• MGIID: 1918560
• Length: 1264
• Species: Mus musculus
• Alignment Length: 1367
• Identity: 444/1367 - (32%)
• Similarity: 685/1367 - (50%)
• Gaps: 206/1367 - (15%)

  Fly     1 MWIQPKELLLPSAFWIAEMHSRYFVLQKRRGHGESRGFG----SMLVGTYDSVMNT--KPAPYRI 59
            ||:.|:|:||.:|.||.|..:.||:||:|:|||...|.|    .:||||.|.|:::  :.|||||
Mouse     1 MWVNPEEVLLANALWITERANPYFILQRRKGHGGDGGGGGGLAGLLVGTLDVVLDSSARVAPYRI 65

  Fly    60 LHQTPSSEVSYEIAIGITQDEIVKDWEWLKANLFKVLDEMENEDEVTNFTICKIQSLYTQNNQ-D 123
            |:|||.|.|.:.||.|.::.|:.:.||||:.||.:.|...|||::||.|...|||.:..:.|: :
Mouse    66 LYQTPDSLVYWTIACGGSRKEVTEHWEWLEQNLLQTLSIFENENDVTTFVRGKIQGIIAEYNKIN 130

  Fly   124 DTGESAD---FKVMKSKFRQIFKMPEEERLVISYSATYVKNKIPRQGQLYISLNHVCFYSYMLGQ 185
            |..|..|   ||....||.::|.|||||:||..||.:|.|.::||||.:|:|:||:||.|:::|:
Mouse   131 DVKEDEDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGRVPRQGWMYLSINHLCFSSFLMGR 195

  Fly   186 EIKRIIRFAELEDISRNANTIYLK-----TTNNMTYNFTMLFNASDAHLLIEQLNKMAIQQLIHD 245
            |.|.:||:.::..:.:|| |:.|.     :|.:..:.|::..|.::...|:|||..:|::||:
Mouse   196 EAKLVIRWVDITQLEKNA-TLLLPDMIKVSTRSSEHFFSVFLNINETFKLMEQLANIAMRQLL-- 257

  Fly   246 PDSPVVDHDTSNFSRLGSKTSKK-PVLLRDLTARQKSEEFRIYFRLPQSEIIDGKIKANIWTPYS 309
             |:...:.|.| ..:|..|:.|| ..|.|||.||.|||.:|..||||:.|.:||.....:|||::
Mouse   258 -DNEGFEQDRS-LPKLKKKSPKKVSALKRDLDARAKSERYRALFRLPKDEKLDGHTDCTLWTPFN 320

  Fly   310 KRFNSGFIYLSPNFFCFRSDVKDLVSVVIPMKTIKSVEKKDDGQQRFENQIVIITSENVPFMFAH 374
            |....|.:::|.|:.||.|..::|.|::||::.:..|||.|.... ..:.:.|.|...:.|:||:
Mouse   321 KMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKADSCSV-LPSPLSISTRNRMTFLFAN 384

  Fly   375 IVDRAVLISKITDLLARVHVPLSRER-------AKYDISWSKQTALMNT---------------- 416
            :.||..|:.:|:|.|.:....:..::       :..|..:|:.::|:::
Mouse   385 LKDRDFLVQRISDFLQQTTSRIYSDKEFSGSCNSSDDEVYSRPSSLVSSSPQRSTSSDADGERPF 449

  Fly   417 -------------------------FKTQFSAEIIQKQEEKMVRWEAHFRDFGRGIGMFRTTDVI 456
                                     |..:.:.|.:::|     .|:.||.::|:||.|:||....
Mouse   450 NLNGNSVPTATQTLMTMYRRRSPEEFNPKLAKEFLKEQ-----AWKIHFAEYGQGICMYRTEKTR 509

  Fly   457 NLIVEGIPDKLRQEIWLIFSGAIHDKEMNPGLYEDLVEKAACIKNCFAHDEIDRDLPRSLPEHPA 521
            .|:::|||:.:|.|:||:.||||::|..:||.||.||||:....| .|.:||:|||.||||||||
Mouse   510 ELVLKGIPESMRGELWLLLSGAINEKATHPGYYEGLVEKSMGKYN-LATEEIERDLHRSLPEHPA 573

  Fly   522 FQSTDGIGALRRVLQAYALRNPQVGYCQAMNIVSSVFLLFCDEENAFWMLASLCENLLPDYYKDK 586
            ||:..||.||||||.|||.|||.:|||||||||:||.||:..||.|||:|.:|||.:|||||..:
Mouse   574 FQNEMGIAALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTR 638

  Fly   587 VVGAQIDQGVLNELVETHLPDLHGHLEQLGVIKMISISWFLTIFMSVISYESSLHILDCFFYEGA 651
            ||||.:||||..||...::|.|:..::.||||..||:|||||:|:||:.:||::.::|||||||.
Mouse   639 VVGALVDQGVFEELARDYVPQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGI 703

  Fly   652 KIIFMISLQIIEWNRDKLLICQDDGEAMLVLQNYLEGVYNPEYQVPPTTDKRKM----ERKVQTQ 712
            |:||.::|.:::.|.||||.|:||||||.||..||:.|.|.:..:||......:    .......
Mouse   704 KVIFQLALAVLDANVDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVGPYPAV 768

  Fly   713 TVQTLIHEAYTKFGEDITQQRIEELRNKHRRLTMRQFDIDNEKTIVKAYVQNPYFNRSELHMLLT 777
            .:..||..:|.||| .|....||::|.|.|...::..:...::.:|:..|....|...||..|..
Mouse   769 DIFRLIGTSYEKFG-TIRADLIEQMRFKQRLKVIQTLEDTTKRNVVRTIVTETSFTIDELEELYA 832

  Fly   778 IIREEKHALKSLQQQQQKVQCPLSETPQLVPQSTSRPIQDAGASGGRYEAYSVSYEVFHTLFTEL 842
            :.:.|           ....|...        .:|..:.....|....|.|.:.:|.|..:|..|
Mouse   833 LFKAE-----------HLTSCYWG--------GSSNALDRHDPSLPYLEQYRIDFEQFKGMFVLL 878

  Fly   843 TPWRKCVSVDI-GEKLFRLTDKKGTGVLDFGQLINALGLVCSNKNMEKLKLLYVLHLPPLLSKAE 906
            .||......|: ..:||:|.|:.|..:::|.:.::.|...|.....|||||||.:|:
Mouse   879 FPWACGTHSDVLASRLFQLLDENGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHV-------- 935

  Fly   907 IERSRRPRPR-TKDDAEEAFEAEDFFDNDAS-ESMEALPSPSDHNFDADD-FALISATQHLHNLA 968
                 .|.|. .:|:.:.||||..:|..|.: |....:...|.....||| |..:|..|.....|
Mouse   936 -----LPEPSCDQDEPDSAFEATQYFFEDITPECTHVVGLDSRGKQSADDGFVTVSLKQDRGKRA 995

  Fly   969 GISGN-TFMDLSRTPNLSVNSNTSSLAHRSSTFYVDLPGFQGTATSTDAGRDEDELQRQLRQQGR 1032
            ....| .::.|....|.|.:.....|...:...:::|........|.|.  :|.||
Mouse   996 NSQENRNYLKLWTAENKSKSKTAKDLPKLNQGQFIELCKTMYNMFSEDP--NEQEL--------- 1049

  Fly  1033 YESIDTFS----DISDLGAARITPPEAGVGADVVAGAASSAAADHMLLNVETISNFSQISDLVAA 1093
            |.:....:    :|.::|...||.|   ...|.|.|.....|...||...:..|....:......
Mouse  1050 YHATAAVTSLLLEIGEVGKFFITQP---AKEDAVPGPPCGQAIPGMLFPKKGSSQSYVVESTEPL 1111

  Fly  1094 TRLERVDSNATDLRSLGSLGYLLD------QP-DEGASNSQHSIPHMRKENFQLLWRSIIEIMGL 1151
            |....|||   :..|||  |.:.|      .| |.||.:|.                       |
Mouse  1112 TASLAVDS---EEHSLG--GQMEDIKLEDSSPRDNGACSSM-----------------------L 1148

  Fly  1152 VQDEEMQRAYENLLELGNSNIKKEPSLESFTQLNMGGDEQPDSNGNPTTPAPEPIGTTRLFVALE 1216
            :.|::               .|.:.|:.|::.|:.|..|:...:       .|.||...:.|
Mouse  1149 ISDDD---------------TKDDSSMSSYSVLSAGSHEEDKLH-------CEDIGEDTVLV--- 1188

  Fly  1217 EELRQASGKSRTTTTSSGDSSSTNISESWHISITQFIATVLTVNSIVRGFQTPIQISEQIEQLQK 1281
               |.:.|::....:||       :...|.|:..||:|::||..::||.|..|:.:..::...:.
Mouse  1189 ---RSSQGRATLPRSSS-------LDRDWAITFEQFLASLLTEPALVRYFDKPVCMMARVTSAKN 1243

  Fly  1282 KR 1283
            .|
Mouse  1244 IR 1245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d8-9	NP_649305.1	PH-GRAM1_TCB1D8_TCB1D9_family	147..249	CDD:275404	39/106 (37%)
		PH-GRAM2_TCB1D9_TCB1D9B	293..389	CDD:270161	31/95 (33%)
		TBC	462..670	CDD:214540	120/207 (58%)
Tbc1d9	NP_001104774.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	36/98 (37%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	31/95 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..456		3/45 (7%)
		TBC	512..722	CDD:214540	120/210 (57%)
		EFh	<893..923	CDD:415501	8/29 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1119..1162		15/85 (18%)