Protein Alignment Tbc1d8-9 and TBC1D9B

DIOPT Version :10

• Sequence 1: NP_649305.1
• Gene: Tbc1d8-9 / 40361
• FlyBaseID: FBgn0037074
• Length: 1291
• Species: Drosophila melanogaster
• Sequence 2: NP_942568.2
• Gene: TBC1D9B / 23061
• HGNCID: 29097
• Length: 1250
• Species: Homo sapiens
• Alignment Length: 1410
• Identity: 430/1410 - (30%)
• Similarity: 664/1410 - (47%)
• Gaps: 292/1410 - (20%)

  Fly     1 MWIQPKELLLPSAFWIAEMHSRYFVLQKRRGHGESRGFGSMLVGTYDSVMNT--KPAPYRILHQT 63
            ||:.|:|:|:.:|.|:.|..:.:||||:|||||...|...:||||.|.|:::  :.|||||||||
Human     1 MWLSPEEVLVANALWVTERANPFFVLQRRRGHGRGGGLTGLLVGTLDVVLDSSARVAPYRILHQT 65

  Fly    64 PSSEVSYEIAIGITQDEIVKDWEWLKANLFKVLDEMENEDEVTNFTICKIQSLYTQNNQ------ 122
            ..|:|.:.:|.|.::.||.|.||||:.||.:.|...::|:::|.|...||..:..:.|:
Human    66 QDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIHGIIAEENKNLQPQG 130

  Fly   123 -DDTGESADFKVMKSKFRQIFKMPEEERLVISYSATYVKNKIPRQGQLYISLNHVCFYSYMLGQE 186
             :|.|:   ||..:.|.|:.|.|||.|:||..||.:|.|.::||||.||:::||:||||::||:|
Human   131 DEDPGK---FKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLYLTVNHLCFYSFLLGKE 192

  Fly   187 IKRIIRFAELEDISRNANTIYLKT----TNNMTYNFTMLFNASDAHLLIEQLNKMAIQQLIHDPD 247
            :..::::.::..:.:||..::.::    |.:....|:|..|..:...|:|||..:|::||:
Human   193 VSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGETFKLMEQLANLAMRQLL---- 253

  Fly   248 SPVVDHDTSNFSRLGSKTSKKPV--------LLRDLTARQKSEEFRIYFRLPQSEIIDGKIKANI 304
                  |:..|  |..|...:|:        |.|||.||.|:|.:|..||||:.|.:||.....:
Human   254 ------DSEGF--LEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRLPRDERLDGHTSCTL 310

  Fly   305 WTPYSKRFNSGFIYLSPNFFCFRSDVKDLVSVVIPMKTIKSVEKKDDGQQRFENQIVIITSENVP 369
            |||::|....|.:::|.|:.||.|..:|...::||::.:..|||.|.... ..:.:.|.|...:.
Human   311 WTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADSSSV-LPSPLSISTKSKMT 374

  Fly   370 FMFAHIVDRAVLISKITDLLARVH--------------VPLSRERAKYDISWSKQTA-------- 412
            |:||::.||..|:.:|:|.|.:..              |..|.|.:......|:|.|
Human   375 FLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPSTESSPAPQEGSEQPASPASPLSS 439

  Fly   413 ---------------LMNTFKTQFSAEII----QKQEEKMVRWEAHFRDFGRGIGMFRTTDVINL 458
                           |:..|:.....|.:    .|::.|...|..||.::|||:.|:||.....|
Human   440 RQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEESWHIHFFEYGRGVCMYRTAKTRAL 504

  Fly   459 IVEGIPDKLRQEIWLIFSGAIHDKEMNPGLYEDLVEKAACIKNCFAHDEIDRDLPRSLPEHPAFQ 523
            :::|||:.||.|:||:||||.::...:||.|.:||||:.. |...|.:||:|||.||:|||||||
Human   505 VLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSTG-KYSLATEEIERDLHRSMPEHPAFQ 568

  Fly   524 STDGIGALRRVLQAYALRNPQVGYCQAMNIVSSVFLLFCDEENAFWMLASLCENLLPDYYKDKVV 588
            :..||.||||||.|||.|||.:|||||||||:||.||:..||.|||:|.:|||.:|||||..:||
Human   569 NELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVV 633

  Fly   589 GAQIDQGVLNELVETHLPDLHGHLEQLGVIKMISISWFLTIFMSVISYESSLHILDCFFYEGAKI 653
            ||.:|||:..||....||.|...::.||||..||:|||||:|:||:.:||::.|:|||||||.|:
Human   634 GALVDQGIFEELTRDFLPQLSEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKV 698

  Fly   654 IFMISLQIIEWNRDKLLICQDDGEAMLVLQNYLEGVYNPEYQVPPTTDKRKMERKVQTQTVQTLI 718
            |..::|.:::.|.::||.|.|:||||.:|..||:.|.|.:...||....|.:.........:..|
Human   699 ILQVALAVLDANMEQLLGCSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDI 763

  Fly   719 HE----AYTKFGEDITQQRIEELRNKHRRLTMRQFDIDNEKTIVKAYVQNPYFNRSELHMLLTII 779
            .|    :|.|| ..:..:.||::|.|.|...::..:...::::|:|...:..|:..||..|..:.
Human   764 FELLKVSYEKF-SSLRAEDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVF 827

  Fly   780 REEKHALKSLQQQQQKVQCPLSETPQLVPQSTSRPIQDAGASGGRYEAYSVSYEVFHTLFTELTP 844
            : .||.      ..|...|..:...:..|   |.|.         .|.|.:....|..||..|||
Human   828 K-AKHL------ASQYWGCSRTMAGRRDP---SLPY---------LEQYRIDASQFRELFASLTP 873

  Fly   845 WRKCVSVD--IGEKLFRLTDKKGTGVLDFGQLINALGLVCSNKNMEKLKLLYVLHLPPLLSKAEI 907
            | .|.|..  :..::|||.|:....:::|.:.:..:..:......||||:||.|||||.||
Human   874 W-ACGSHTPLLAGRMFRLLDENKDSLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALS---- 933

  Fly   908 ERSRRPRPRTKDDAEEAFEAEDFFDNDAS----------------ESMEALPSPSDHNFDADDFA 956
                      .::||.|.||..:|..|:|                |:.||||........:::..
Human   934 ----------PEEAESALEAAHYFTEDSSSEASPLASDLDLFLPWEAQEALPQEEQEGSGSEERG 988

  Fly   957 LISAT--------------------QHLHNLAGISGNTFMDLSRT--PNLSVNSNTSSLAHRSST 999
            ....|                    :.:.:|..::...|::|.:|  ...|.:.....|.|..:|
Human   989 EEKGTSSPDYRHYLRMWAKEKEAQKETIKDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIAT 1053

  Fly  1000 FYVDL--PGFQGTATSTDAGR-------DEDELQR-QLRQQGRYESIDTFSDISDLGAARITPPE 1054
            ....|  .|..|...|...||       :|||... :|.|.               .|..:.||.
Human  1054 VASLLLRIGEVGKKFSARTGRKPRDCATEEDEPPAPELHQD---------------AARELQPPA 1103

  Fly  1055 AG-----VGADVVAGAASSAAADHMLLNVETISNFSQISDLVAATRLERVDSNATDLRSLGSLGY 1114
            ||     .|.|...|.|                  .|.|.:|.
Human  1104 AGDPQAKAGGDTHLGKA------------------PQESQVVV---------------------- 1128

  Fly  1115 LLDQPDEGASNSQHSIPHMRKENFQLLWRSIIEIMGLVQDEEMQRAYENLLELGNSNIKKEPSLE 1179
                  ||.|......|..                 |:.|:|               .|.:.|:.
Human  1129 ------EGGSGEGQGSPSQ-----------------LLSDDE---------------TKDDMSMS 1155

  Fly  1180 SFTQLNMGGDEQPDSNGNPTTPAPEPIGTTRLFVALEEELRQASGKSRTTTTSSGDSSSTNISES 1244
            |::.::.|..:..|                     |.::.....|::.:.|...|.:..|:
Human  1156 SYSVVSTGSLQCED---------------------LADDTVLVGGEACSPTARIGGTVDTD---- 1195

  Fly  1245 WHISITQFIATVLTVNSIVRGFQTPIQISEQIEQLQKKRRKCLST 1289
            |.||..|.:|::||.:.:|..|:..:.|..:|:. |||..:..||
Human  1196 WCISFEQILASILTESVLVNFFEKRVDIGLKIKD-QKKVERQFST 1239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d8-9	NP_649305.1	PH-GRAM1_TCB1D8_TCB1D9_family	147..249	CDD:275404	35/105 (33%)
		PH-GRAM2_TCB1D9_TCB1D9B	293..389	CDD:270161	30/95 (32%)
		TBC	462..670	CDD:214540	116/207 (56%)
TBC1D9B	NP_942568.2	PH-GRAM1_TCB1D9_TCB1D9B	153..251	CDD:275420	33/97 (34%)
		PH-GRAM2_TCB1D9_TCB1D9B	299..394	CDD:270161	30/95 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..443		6/45 (13%)
		TBC	505..715	CDD:214540	116/210 (55%)
		EFh	886..911	CDD:197492	5/24 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	974..999		3/24 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1069..1093		7/23 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1157		9/88 (10%)