DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsr1 and TSR1

DIOPT Version :9

Sequence 1:	NP_649304.1	Gene:	Tsr1 / 40360	FlyBaseID:	FBgn0037073	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_010223.1	Gene:	TSR1 / 851499	SGDID:	S000002218	Length:	788	Species:	Saccharomyces cerevisiae

Alignment Length:	836	Identity:	257/836 - (30%)
Similarity:	417/836 - (49%)	Gaps:	112/836 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADHAFHRPGPLKQANKAHKTGRHRSKGAIDNAQKGKIGLRPI-SHKHKQQQRKEQRRNQMNQLR 64
            ||.|: || ..||..:|::|: :|.||||:....|||:...|: :.|..:|..|.||:|:..|||
Yeast     1 MAGHS-HR-SSLKNGHKSYKS-KHASKGALKRLYKGKVEKEPVGTGKPDKQVSKLQRKNKAKQLR 62

  Fly    65 KNKREEVLEQKRKLGGQNTAPFLVCLLPMHEQIDPMSAL-EILKSCDSE--LVVENSPSGIVYIN 126
            ..:..:.:|.::...|:|.|..::.::|:...:||:..| ::||..|.|  :|.|.....|..::
Yeast    63 AQRILDSIENRKLFEGKNGAAKIITIVPLVNDLDPLDILYKLLKCADDEGIMVQEVDSKRIFNVH 127

  Fly   127 LPRFKQRFAFVTPPVGRGNELIALDYLKVCDTTLLLTTAAFGDDEIFDRWGQRIFNMMSAQGIPT 191
            :.:||.....:.|.:  .|.|..||..||.|   .:.....|..|:.:.:|::|...:..|||.:
Yeast   128 IKKFKSNLKIIIPDM--TNFLNILDCAKVAD---FVVFGLSGVQEVDEEFGEQIIRALELQGIAS 187

  Fly   192 PVVALMDLESINPKRR--PAAKQAAQKVISKLLP-EEKIMQLDTASEALNVMRRIGGQKKRILHN 253
            .:..:.:|.:::.|.:  ...||:.:.......| ||::..|:..|:||||:|.:..:..|.::.
Yeast   188 YIGVISNLSAVHEKEKFQLDVKQSLESYFKHFFPSEERVYNLEKNSDALNVLRTLCQRLPRSINW 252

  Fly   254 VANRPHLFGDVVEFKPGSDPSDDLGTLEVTGFLRGQSLNVNGLVHIPGLGDFQLSQVVAPPDPYK 318
            ..||.::..|.|:|   .:.|.|.|.|.:.|.:||...|.|.|||||..|||||:::
Yeast   253 RDNRGYVVADFVDF---VETSPDSGDLVIEGTVRGIGFNANRLVHIPDFGDFQLNKI-------- 306

  Fly   319 LDKSRDGENSEVRLLDRSDPSKRTSL--------QSENIPDPMD-----AEQTWPTEDE------ 364
               .:..|:|:.|.:.:...:...||        :|....|.:|     ..:.|...||
Yeast   307 ---EKISESSQKRKIIKEKATDSLSLELDLQTVFESNMNRDTLDEYAPEGTEDWSDYDEDFEYDG 368

  Fly   365 -----------IAASQAETKKMKLVKRVPKGYSEYQAAW-IPDV------EEVEDPDGKDDDDMS 411
                       :...:..:||    ..||||.|:|||.| :.||      ||.|..:|||:..|.
Yeast   369 LTTARYDDHGFLPGREQTSKK----AAVPKGTSDYQAKWYLDDVIDANEEEEAEQTNGKDETMME 429

  Fly   412 EDDDDDKEDDNEDFMSCDNKSFEDEYEKRDSDTEEFQDTVSVASEAAINDEKYDQQMDFQEERET 476
            .||:...|.|||:...      ::||:..|                   :|.:::....:|||:.
Yeast   430 IDDEMMVEQDNEEVAG------DEEYDIED-------------------NEGFEELSPEEEERQL 469

  Fly   477 LKKLQQARTDQLWPDEIDTPLDVPARERFQKYRGLESFRTSPWDAKE---NLPADYARIYQFQNF 538
            .:.....:.|:.:||||:......|.||.::||||::.....|...|   :.||::.|:.:..|:
Yeast   470 REFRDMEKEDREFPDEIELEPSESAIERLKRYRGLKNLYNCDWQVDEKDPSSPAEWKRLLRIGNY 534

  Fly   539 DRTKRRILNEAKEFEGVLPGLYVTLYVINVPESRWNAFKSAQLMDN----IIVYGMLPHEHQMCV 599
            ..||.||:.|.|.....:.|..:.:::      |:..|...::.|.    ..|||:|.|||:..|
Yeast   535 KNTKNRIIKETKNEAQAIAGDRIRMFI------RFPKFLLEKIQDPKQLLFAVYGLLLHEHKNAV 593

  Fly   600 MNVVLQRMPDSEVPLKSKEQLIIQCGYRRFVVNPIYSQHTN--GDKHKFERYFRPYETVCATFYA 662
            :|..|||....:.|:.|:|.:::|.|.||:.:.|::||.:|  .:.||:||:..|.....||..|
Yeast   594 VNFSLQRWEQYDKPVPSQEPIVVQYGVRRYTIQPLFSQGSNSPNNVHKYERFLHPDTVSVATCIA 658

  Fly   663 PIQFPPAPVLAFKVNPD--STLALVARGRLLSCNPDRIVLKRVVLSGHPMRINRKSASIRYMFFY 725
            |:.|..:|.:.||.:|.  ..:.|:..|..|:.:..||:.||.:|:|||.|.::...::|||||.
Yeast   659 PVDFTQSPAIFFKPSPTDAKNIELIGHGTFLNADHSRILAKRAILTGHPFRFHKTVVTVRYMFFR 723

  Fly   726 KEDVEYFKPVKLRTKCGRLGHIKESLGTHGHMKCYFDGQLRSYDTAFMYLYKRVFP 781
            .||||:||.:.|.||.||.|.|||||||||:.|..|||:|.:.|...|.||||::|
Yeast   724 PEDVEWFKSIPLFTKSGRSGFIKESLGTHGYFKATFDGKLSAQDVVAMSLYKRMWP 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsr1	NP_649304.1	COG5177	17..781	CDD:227504	249/818 (30%)
Tsr1	NP_649304.1	RIBIOP_C	493..781	CDD:368206	110/298 (37%)
TSR1	NP_010223.1	COG5177	4..788	CDD:227504	255/833 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344447
Domainoid	1	1.000	206	1.000	Domainoid score	I526
eggNOG	1	0.900	-	-		E1_COG5177
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5576
Inparanoid	1	1.050	367	1.000	Inparanoid score	I366
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54181
OrthoFinder	1	1.000	-	-		FOG0005046
OrthoInspector	1	1.000	-	-		oto100271
orthoMCL	1	0.900	-	-		OOG6_102221
Panther	1	1.100	-	-	LDO	PTHR12858
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1563
SonicParanoid	1	1.000	-	-		X3570
TreeFam	1	0.960	-	-
	15	14.790