DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsr1 and tag-151

DIOPT Version :9

Sequence 1:	NP_649304.1	Gene:	Tsr1 / 40360	FlyBaseID:	FBgn0037073	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_494840.1	Gene:	tag-151 / 173812	WormBaseID:	WBGene00006497	Length:	785	Species:	Caenorhabditis elegans

Alignment Length:	800	Identity:	303/800 - (37%)
Similarity:	461/800 - (57%)	Gaps:	72/800 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 HRPGPLKQANKAHKTGR-HRSKGAIDNAQKGKIGLRPI---SHKHKQQQRKEQRRNQMNQLRKNK 67
            ||.|..|:.:|.||:.: .|:||.|.:..:|:.|::.:   :|...:...|:.||||:...|..|
Worm     6 HRAGVFKKPSKPHKSWKGKRTKGEITSENRGREGVKQLTRSAHSTHRTISKDARRNQLKMARDQK 70

  Fly    68 REEVLEQKRKLGGQNTAPFLVCLLPMHEQIDPMSALEILKSCDSELVVENSPSGIVYINLPRFKQ 132
            ..:.:|::|    .:.||.||.::.:.....|...::.|.:||..::...|||.|.:. :||||.
Worm    71 MADAMERRR----TSNAPCLVTVVSLGVGARPTEFIKKLATCDETIIQTTSPSTIDFA-IPRFKS 130

  Fly   133 RFAFVTPPVGRGNELIALDYLKVCDTTLLLTTAAFGDDEIFDRWGQRIFNMMSAQGIPTPVVALM 197
            |.:|:||  .:.|....||.::..|....|...:....|    |.:::..::.|.|:||.|..:.
Worm   131 RVSFLTP--DKDNVDGVLDAIRASDVLCFLWPMSAELSE----WDEQLLTIIKANGLPTIVSVVP 189

  Fly   198 DLESI-NPKRRPAAKQAAQKVISK-LLPEEKIMQLDTASEALNVMRRIGGQKKRILHNVANRPHL 260
            .|.|| |.|::...::..:.:||| .:....:|..|:.::.|.::|.:...||:.|...|...::
Worm   190 GLGSIANHKKKEDVRKGIEFIISKWSMSNAGVMPADSVTDNLQLLRILNETKKKPLTLQARHSYM 254

  Fly   261 FGDVVEFKPGSDPSDDLGTLEVTGFLRGQSLNVNGLVHIPGLGDFQLSQVVAPPDPYKLDKSRDG 325
               :||....||.:.:..||...|:|||...|.|.|||:||.||||:|::.:..||:.|  ....
Worm   255 ---LVENLECSDKTGETCTLVAQGYLRGPEWNANNLVHLPGFGDFQISKIESTVDPHPL--KAHN 314

  Fly   326 ENSEVRLLDRSDPSKRTSLQSENIPDPMDAEQTWPTEDEIAASQAETKKMKLVKRVPKGYSEYQA 390
            :..|.:::.:|| .||.:.::|..||.||.||||||.:|:..:..|      ::|||||.|.|||
Worm   315 KTPEAQIIAKSD-DKRQNTETEITPDSMDGEQTWPTREELEEADKE------LRRVPKGTSSYQA 372

  Fly   391 AWIPDVEEVEDPDGKDDDDMSEDDDDDKEDDNEDFMSCDNKSFEDEYEKRDSDTEE-FQDTVSVA 454
            |||.|                ::||:|:||.:||....||:..||     ||:.|| ..|..|.|
Worm   373 AWILD----------------DEDDEDEEDSDEDMDDSDNEEVED-----DSEEEEPMDDLKSEA 416

  Fly   455 SEAAINDEKYDQQMDFQEERETLKKLQQARTDQLWPDEIDTPLDVPARERFQKYRGLESFRTSPW 519
            .|...::..:|..:|.......::|.::.|.:..||||:|||:|:|||..|||||||:|||||.|
Worm   417 GETTASEMMFDDGIDEDINMAEVEKYRKERENAQWPDEVDTPMDMPARIAFQKYRGLKSFRTSTW 481

  Fly   520 DAKENLPADYARIYQFQNFDRTKRRILNEA------------KEFEGVLPGLYVTLYVINVPESR 572
            |.|||||.|||||:||.|:..||:.::::.            |:|.|.    :.::::.|||.:.
Worm   482 DPKENLPLDYARIFQFANYRNTKKNVMSKIGGNDVDADSVADKKFNGA----FASVFIENVPVAV 542

  Fly   573 WNAFKSAQLMDNIIVYGMLPHEHQMCVMNVVLQRMPDSEVPLKS--KEQLIIQCGYRRFVVNPIY 635
            ..|:|.|:   |::::.:|||||:|.|:|:||::.|...:|:.|  .::.|...|:|:|..|.::
Worm   543 LEAYKDAK---NLVLFQLLPHEHKMSVLNMVLKKHPSCTIPITSDQNQKFIFYVGFRQFEANAVF 604

  Fly   636 SQHTNGDKHKFERYFRPYETVCATFYAPIQFPPAPVLAFKVNPDSTLALVARGRLLSCNPDRIVL 700
            |.:|.|||.|.||:....:|..||.||||.|.||.||.|:.:......|||.|.:|..|||||||
Worm   605 SSNTPGDKFKLERFMPTEKTFVATVYAPITFNPATVLCFRQDDKGRQELVATGSILDSNPDRIVL 669

  Fly   701 KRVVLSGHPMRINRKSASIRYMFFYKEDVEYFKPVKLRTKCGRLGHIKESLGTHGHMKCYFDGQL 765
            ||.||:|||.:|||::..:|||||.:||:|:||||:|.|..||.|||||::||||:|||.||.||
Worm   670 KRTVLAGHPYKINRRAVVVRYMFFNREDIEWFKPVELYTPSGRRGHIKEAVGTHGNMKCRFDQQL 734

  Fly   766 RSYDTAFMYLYKRVFPKWTY 785
            .:.|:..:.|||||||.|.|
Worm   735 NAQDSVMLNLYKRVFPVWNY 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsr1	NP_649304.1	COG5177	17..781	CDD:227504	295/784 (38%)
Tsr1	NP_649304.1	RIBIOP_C	493..781	CDD:368206	145/301 (48%)
tag-151	NP_494840.1	COG5177	16..750	CDD:227504	295/784 (38%)
		AARP2CN	229..308	CDD:129021	29/81 (36%)
		RIBIOP_C	457..748	CDD:282764	142/297 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161279
Domainoid	1	1.000	298	1.000	Domainoid score	I782
eggNOG	1	0.900	-	-		E1_COG5177
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5576
Inparanoid	1	1.050	525	1.000	Inparanoid score	I675
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54181
OrthoDB	1	1.010	-	-		D130256at33208
OrthoFinder	1	1.000	-	-		FOG0005046
OrthoInspector	1	1.000	-	-		oto18412
orthoMCL	1	0.900	-	-		OOG6_102221
Panther	1	1.100	-	-	LDO	PTHR12858
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1563
SonicParanoid	1	1.000	-	-		X3570
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840