DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tsr1 and Tsr1

DIOPT Version :9

Sequence 1:	NP_649304.1	Gene:	Tsr1 / 40360	FlyBaseID:	FBgn0037073	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_002727820.1	Gene:	Tsr1 / 100360406	RGDID:	2322150	Length:	804	Species:	Rattus norvegicus

Alignment Length:	817	Identity:	360/817 - (44%)
Similarity:	513/817 - (62%)	Gaps:	73/817 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 AFHRPGPLKQANKAHKTGRHRSKGAIDNAQKGKIGLRPISHKHKQQQRKEQRRNQMNQLRKNKRE 69
            |.||.|||||.|||||.|||...|:.....||::|.:.:..|.|:|..:..:|::.:||||.|||
  Rat     2 AAHRSGPLKQQNKAHKGGRHHGGGSAQRDSKGRVGPKILCKKLKKQLSRVDQRHRASQLRKQKRE 66

  Fly    70 EVLEQKRKLGGQNTAPFLVCLLPMHEQIDPMSALEILKSCDSELVVENSPSGIVYIN-------- 126
            .||.:||:||.::..|..|.::|:|.:|....|.::|         :|...|.||:|
  Rat    67 AVLAEKRQLGSKDGPPHQVLVVPLHNRICLPEAFKLL---------QNEDLGTVYLNERGSTHSF 122

  Fly   127 ---LPRFKQRFAFVTPPVGRGNELIALDYLKVCDTTLLLTTAAFGDDEIFDRWGQRIFNMMSAQG 188
               .|..|.|::|.....|..:.|  ||..||.||.|.|.....|    :|..|....:.:.|||
  Rat   123 MLLSPSLKHRWSFTYARPGDLHTL--LDMAKVADTILFLLDPLEG----WDSTGDYCLSCLFAQG 181

  Fly   189 IPTPVVALMDLESINPKRRPAAKQAAQKVISKLLPEEKIMQLDTASEALNVMRRIGGQKKRILHN 253
            :||.::|:..|.|:.|||:..|::...|.:.|..||:|::.|||..|:..::|::..||:|.|..
  Rat   182 LPTYMLAVQGLPSLPPKRQTDARKKLNKTVEKRFPEDKLLLLDTQQESGMLLRQLANQKQRHLAF 246

  Fly   254 VANRPHLFGDVVEFKPGSDPSDDLGTLEVTGFLRGQSLNVNGLVHIPGLGDFQLSQVVAPPDPYK 318
            ...|.:||....:|.| |:.||.:|||:::|::||::||||.|:||.|.||||::|:.||.||:.
  Rat   247 RDRRAYLFAHDADFMP-SEESDLVGTLKISGYIRGRTLNVNSLLHIVGHGDFQMNQIDAPVDPFP 310

  Fly   319 L--------------------DKSRDGENSEVRLLDRSDPSKRTSLQSENIPDPMDAEQTWPTED 363
            |                    |.:.|.|.. :::|.::||.::.:||:|.|||||:.|||||||:
  Rat   311 LNPRVVKSQKKPSMSMEVCVTDAAADMEEG-LKVLMKADPDQQETLQTEVIPDPMEGEQTWPTEE 374

  Fly   364 EI-AASQAETKKMKLVKRVPKGYSEYQAAWIPDVEEVEDPDGKDDDDMSEDDDDDKEDDNEDFMS 427
            |: .|:.:..::.::||:||||.|.|||.||  ::|.::.||:.|    |.|||.:   :|.||
  Rat   375 ELDEANDSLKQRSRVVKKVPKGTSNYQAEWI--LDEGDESDGEGD----ESDDDIQ---HEGFM- 429

  Fly   428 CDNKSFEDEYEKRD-SDTEEFQDTVSVASEAAINDEKYDQQMDFQEERETLKKLQQARTDQLWPD 491
                    |.|.:| |..||.::..::....::.|:.||:::|.::|...|:|.:|.|.::::||
  Rat   430 --------EEESQDGSGEEEEEECETMTLGESVRDDLYDEKVDEEDEERMLEKYKQERLEEMFPD 486

  Fly   492 EIDTPLDVPARERFQKYRGLESFRTSPWDAKENLPADYARIYQFQNFDRTKRRILN--EAKEFEG 554
            |:|||.||.||.||||||||:||||||||.|||||.|||||:|||||..|::||..  |.||.||
  Rat   487 EMDTPRDVAARIRFQKYRGLKSFRTSPWDPKENLPRDYARIFQFQNFVNTRKRIFKEIEEKETEG 551

  Fly   555 VLPGLYVTLYVINVPESRWNAFKSAQLMDNIIVYGMLPHEHQMCVMNVVLQRMPDSEVPLKSKEQ 619
            ...|.||||:|.|||.|...:|:...   .:|.:.:||:|.:|.|:|:|:.|.|.:..|:|:||:
  Rat   552 AEVGWYVTLHVSNVPVSVVESFRQGA---PLIAFSLLPYEQKMSVLNMVVSRSPGNTEPVKAKEE 613

  Fly   620 LIIQCGYRRFVVNPIYSQHTNGDKHKFERYFRPYETVCATFYAPIQFPPAPVLAFKVNPDSTLAL 684
            ||..||:|||..:|::||||..|||||:|:......:..|.:|||.||||.||.||...:...:|
  Rat   614 LIFHCGFRRFRASPLFSQHTAADKHKFQRFLTADAALVVTVFAPITFPPASVLLFKQRRNGMHSL 678

  Fly   685 VARGRLLSCNPDRIVLKRVVLSGHPMRINRKSASIRYMFFYKEDVEYFKPVKLRTKCGRLGHIKE 749
            :|.|.|.|.:|||:|:|||||||||.:|..|:|.:|||||.::||.:||||:||||.||.|||||
  Rat   679 IATGHLFSVDPDRMVIKRVVLSGHPFKIFTKTAVVRYMFFSRDDVLWFKPVELRTKWGRRGHIKE 743

  Fly   750 SLGTHGHMKCYFDGQLRSYDTAFMYLYKRVFPKWTYE 786
            .|||||||||.|||:|:|.||..|.|||||||||||:
  Rat   744 PLGTHGHMKCSFDGKLKSQDTVLMNLYKRVFPKWTYD 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsr1	NP_649304.1	COG5177	17..781	CDD:227504	345/798 (43%)
Tsr1	NP_649304.1	RIBIOP_C	493..781	CDD:368206	166/289 (57%)
Tsr1	XP_002727820.1	COG5177	32..775	CDD:227504	334/777 (43%)
		P-loop_NTPase	<130..255	CDD:304359	41/124 (33%)
		AARP2CN	228..308	CDD:285368	35/79 (44%)
		RIBIOP_C	490..773	CDD:282764	161/284 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343833
Domainoid	1	1.000	338	1.000	Domainoid score	I1077
eggNOG	1	0.900	-	-		E1_COG5177
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5576
Inparanoid	1	1.050	647	1.000	Inparanoid score	I771
OMA	1	1.010	-	-		QHG54181
OrthoDB	1	1.010	-	-		D130256at33208
OrthoFinder	1	1.000	-	-		FOG0005046
OrthoInspector	1	1.000	-	-		oto98603
orthoMCL	1	0.900	-	-		OOG6_102221
Panther	1	1.100	-	-	LDO	PTHR12858
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3570
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770