DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP2 and lrp-1

DIOPT Version :10

Sequence 1:NP_004516.2 Gene:LRP2 / 4036 HGNCID:6694 Length:4655 Species:Homo sapiens
Sequence 2:NP_001379135.1 Gene:lrp-1 / 172520 WormBaseID:WBGene00003071 Length:4753 Species:Caenorhabditis elegans


Alignment Length:5006 Identity:1713/5006 - (34%)
Similarity:2547/5006 - (50%) Gaps:644/5006 - (12%)


- Green bases have known domain annotations that are detailed below.


Human     5 PAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQ 69
            |.:|...::.|.|    ..:...|:...|||..|.||..:|:|||:.||||..||..|....|:.
 Worm    34 PPSVRSRIISASV----NTASSVCNENDFRCNDGKCIRTEWKCDGSGDCSDGEDEKDCPHPGCKS 94

Human    70 GYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEY-RCDHVRDC 133
                         :.|.||                  |.:.|.::|.      :|| |||::.||
 Worm    95 -------------DQWQCD------------------TYTWHSVSCI------AEYQRCDNITDC 122

Human   134 PDGADENDCQYPT--CEQ----LTCDNGACYNTSQKCDWKVDCRDSSDE-INCTE---ICLHNEF 188
            .||:||.||...|  |..    :..|...|::.|:|||.|.||||.||| .:|:.   .|...:|
 Worm   123 ADGSDEKDCPASTVDCSSQNVFMCADGRQCFDVSKKCDGKYDCRDLSDEKDSCSRNHTACFQYQF 187

Human   189 SCGN-GECIPRAYVCDHDNDCQDGSDE-HACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNG 251
            .|.: .:||.:::|||...||.||||| ..|.:..|...:|.|.:.||..:.:.||..|||.||.
 Worm   188 RCADKTQCIQKSWVCDGSKDCADGSDEPDTCEFKKCTANEFQCKNKRCQPRKFRCDYYDDCGDNS 252

Human   252 DEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALN 316
            |||.|..     ::|.|.:|:||.:|.||...|:|||..||....||      :.||..||.:|.
 Worm   253 DEDECGE-----YRCPPGKWNCPGTGHCIDQLKLCDGSKDCADGADE------QQCSQNLCPSLG 306

Human   317 CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCES-RPGRHLCHC------- 373
            ||..||.:|:||.|.||.||.::....|||.:.::|..:|.|||.|.: ||| ..|.|       
 Worm   307 CQAGCHPSPHGGECTCPSGYKLDDRFHRTCSDINECAEFGYCDQLCANHRPG-FTCSCLGDCFTL 370

Human   374 --EEG----YILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGV------- 425
              |.|    .:..|| ||.:|::  :...:|...|:.|        :|:..::.:..|       
 Worm   371 QMEHGPGKDNLTMRG-YCVSNNA--DKMKLFVARREGL--------YRLNPKNPDEEVKKLASGE 424

Human   426 -AVGVAFHYHLQRVFWTDTVQNKVFSVDINGL-NIQEVLNVSVET---PENLAVDWVNNKIYLVE 485
             ..|:.|.|..:::||||.:.:..||.|::.. .|.::..:|:::   |..|||||:.|.:|::|
 Worm   425 FIYGIDFDYGDRKIFWTDRLAHSAFSADVDDEGEISQIKKLSLKSLVYPRCLAVDWITNTLYIIE 489

Human   486 TKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKD 550
            :...|||:.:.||..|..|:.:.|..|..||:||..|.:||::      :.|||.|.|||:||:.
 Worm   490 SGSRRIDVSSYDGERRTVLLADGLTLPLDIALDPLRGEMFFTN------QLKLEAAAMDGTNRRT 548

Human   551 LVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVF 615
            ||.|.....:|:.:|:.:|||||||.:.|.:|::.|.|..|:.|..|.:::|||||::||:..::
 Worm   549 LVNTHTHQVSGIVVDITAKRVYWVDPKVDRLESIDYQGNDRRIVAQGMNVVPHPFGLALFDQYLY 613

Human   616 FTDWTKMAVLKANKF----------TETNPQVYYQASLRPYGVTVYHSLRQP----------YAT 660
            :||||::.|::..||          ||.|        :.|.|::.||.:.||          ...
 Worm   614 WTDWTRLGVIQVEKFGSDTKLLWSNTENN--------VFPMGISAYHPMAQPGPGQSECLAMKIE 670

Human   661 NPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGI--P 723
            |||  .|..||.:|:||......|:|::|.|..|.:|...:| ||...::|:|||...:|||  .
 Worm   671 NPC--TNADCEGMCILSKDNGGFGVGYKCACPIGQKLVNGKR-CIDSIDYLLFSSNKIVRGIFPE 732

Human   724 FTLSTQEDVMVPVSGNPSFFVGIDF----DAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVE 784
            .......:.::|:|......:|:.|    |...::.|::|:..:.|::.:.||.|...:.....:
 Worm   733 INEKALAEAVLPISPISQRRIGMYFEVECDVHGNSFFYADIMDNTIYRIRPDGEGAAPVLVTHND 797

Human   785 NVESLAFDWISKNLYWTDSHYKSISVMRLADK--------TRRTVVQYLNNPRSVVVHPFAGYLF 841
            .:.|::||||||.||:.|:...|:.|:::.:.        .||.::..|.:|.||||||:.|.||
 Worm   798 GLFSMSFDWISKQLYYVDNIRNSLEVVKIGETGLVHPDELVRRQLITELRDPVSVVVHPWKGLLF 862

Human   842 FTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRR 906
            :.:..|||.|.|...||.:...:.|||||.|:.:|||:|.:||.|.|.....|....|||.:..:
 Worm   863 YAEAMRPAAIYRCHIDGQNCQVIRNTTLGRPSEMAIDFAENRLCWGDTLLKTISCMDFDGKNVVK 927

Human   907 LGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIA---YILHLKSYDVNIQ 968
            |.....:  |..:.|..|::::...|..:|.||.|.:||...::|...|   .|..||       
 Worm   928 LDIDNPI--PVAITIMNEYIYYVHQRPYSIRRVHKKNGGGSKIVREFGADERSIFSLK------- 983

Human   969 TGSNAC---NQP------THP--NGDCSHFCFPVPN------FQRVCGCPYGMRL--ASNHLTCE 1014
                ||   |||      .||  ...|:..||..|:      .:..|.|..|..:  .:|| :|:
 Worm   984 ----ACSHQNQPIPDDSREHPCRASQCTQLCFATPSESHPNELEAKCACRQGFMINKENNH-SCQ 1043

Human  1015 GDPTNEPPTEQCGLFS--FPCKNGRCVPNYYLCDGVDDCHDNSDE-----QLCGTLNNT-CSSSA 1071
            .||. |...:.|...|  |.||||||:|..:.|||.:||.|.|||     ..|  .:.| |:.:.
 Worm  1044 KDPA-EKIEQLCSSNSTQFQCKNGRCIPKEWKCDGENDCLDESDEIDEKGDKC--FHETECAENT 1105

Human  1072 FTCGH-GECIPAHWRCDKRNDCVDGSDE--HNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDND 1133
            ..|.: .:||||.:.||..|||.|.|||  ..|.......|...::.||||:||.:.|.||:|||
 Worm  1106 IKCRNTKKCIPAQYGCDGDNDCGDYSDEDVKYCKDGQKPVCAAKKFQCDNHRCIPEQWKCDSDND 1170

Human  1134 CGDGSDEK--NCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDE--VGC-VLNCTASQFK 1193
            ||||||||  .|.:. ||..:||:|.|.|||.:.::||||.||.||:||  ..| .:.|:|.||:
 Worm  1171 CGDGSDEKLEMCGNA-TCAANQFSCANGRCIPIYWLCDGDNDCYDGTDEDKERCPPVQCSALQFR 1234

Human  1194 CASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLY 1258
            ||:|.:|:.:.|.|||..||.|.|||..|...... |..|:|:|...|:|||..|:|||..||..
 Worm  1235 CANGRQCVPLRNHCDGQSDCEDGSDEDSCAVTAES-CTPDQFKCVSSGLCIPASWKCDGQQDCDD 1298

Human  1259 GSDEHN-ACVP-KTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDE------------KDCPTQP 1309
            ||||.. .|.. :.|.|..|.|.||.||...||||.:|||||.|||            :.||.:.
 Worm  1299 GSDEPKFGCTSGRQCSSDQFKCGNGRCILNNWLCDGENDCGDGSDESSERGCKTSMNARKCPFEH 1363

Human  1310 FRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCL 1374
            ..|.:.|      ..|:.|..:|||...||.||||...|..:.||....||:.:|...|.|..|.
 Worm  1364 VACENDQ------ETCIPLHQLCDGKTHCPGGTDEGGRCARDLCSADRAGCSFKCHNSPNGPICS 1422

Human  1375 CPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTAS-ESLLL 1438
            ||.|..|.|.:| ||..:||....||||.|.:.:..|.||||.||.|:.|.|||||..: :...:
 Worm  1423 CPFGEQLVNKTK-CEPENECLDSSSCSQRCKDEKHGFTCSCDEGYELDVDKRTCKVADNVKDTRI 1486

Human  1439 LVASQNKI-IADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRV 1502
            .|:::|:| .:|......|...::|||.   :|:.:||::.||:|||..:.|..||.:|||:..|
 Worm  1487 YVSNRNRIYYSDHKLDNWHTFGAIVENA---IALAWDSLTDRIYWSDIREKKILSANRNGTNATV 1548

Human  1503 VFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKI-DGSHRTVLISKNLTNPRGLALDPRMNEH 1566
            .....:.:||.||:|||||||||.|.:|.||||:.: |...||:|:.:|::.|||:|:|||  :.
 Worm  1549 FIADGLDITEGIALDWVGRNLYWVDSSLNTIEVANLEDPKQRTLLVHQNVSQPRGIAVDPR--KG 1611

Human  1567 LLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHH 1631
            ::||:|||.:|.||||||||:.|.:||:.||:||..:.:||....:||.||.||::||.:|:|..
 Worm  1612 VMFWTDWGQNPCIERASMDGTDRQIIVKTKIYWPNTIALDYTTDRVYFADSKLDFIDFVNYDGSG 1676

Human  1632 RRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWP-------LGI 1689
            |.||:||...::||:||.:|||.:|::||..:::....|:..|..|      ::|       ||:
 Worm  1677 RTQVLASSKFVQHPHALAIFEDMMYYSDRRLQKLQVYPKYPNGTTS------EYPSHTFSKALGV 1735

Human  1690 VAVHPSKQP---NSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITV 1751
            |||||..||   |  |||:.:.|||||||:::  :.::|.||.|..|......|:.|.:|||:.:
 Worm  1736 VAVHPVLQPVIKN--NPCSTNPCSHLCLLNNK--NTFTCKCPMGEKLDASGKKCIDDAKPFLVII 1796

Human  1752 RQHIIFGISLN----PEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGE------------ 1800
            ::..:|||.:|    .|......|||::|:.|..|..:|...:.::.:|:...            
 Worm  1797 QKTNVFGIEMNSASEKETPVLAGMVPLSGLGNAFDAAYDALSEEMFILEHTNHAKTLAQITTDSA 1861

Human  1801 IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDG 1865
            |:|...:|.|:|...|.::...:..|..||..|||...|..||:||::...|. :||..:::||.
 Worm  1862 IYRSTVNGGNKTKMFSSAVPDDAYCLGFDWNGRNLVVGNKITQTIEIIRTQGK-QYRSVILSNDQ 1925

Human  1866 TALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEE 1930
            :...|..|:.|.||..:|.::|.|:| .....||:|.|.:||::...:.:.:|..|:.:.:|...
 Worm  1926 SPTAVVTPVAIAVDADKGYVFWLDRG-GGAADAKVARAGLDGSNPLVIASNDLAELDHIAIDTTN 1989

Human  1931 QKLYWAVTGRGVIERGNVDGTDR-MILVHQLSHPWGIAVHDSFLYYTDEQYEVIE--------RV 1986
            .::|::....|.|.....||.|| .:|......|.|:|.:...|:|.|..::.||        :.
 Worm  1990 TRVYFSEAKAGRISSVTYDGQDRHYVLSDGGRQPNGLAFYGDRLFYADSAFDSIEVATINGDSQP 2054

Human  1987 DKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKL 2051
            .:.|...|.|  :|:.|::.||    ..|:.|.:.|..|...|..||:|:.....:|.||.|: :
 Worm  2055 PQWTHFKKDV--ENLANIKALQ----PRASSSGHPCHINNGNCDHICIPLMFAQRTCTCANGY-V 2112

Human  2052 NPDNRSCSPYN-SFIVVSMLSAIRGFSL-ELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDF 2114
            .....||..:: ||::|:..:.:.|:.: |.......|.|:.  |.:...||.|..|..||..:.
 Worm  2113 KDGQTSCKLFDESFVIVATKTKVIGYPIDETQSKGVAMEPIG--GLSITGVDYDYESKTIYVAEA 2175

Human  2115 SSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTT 2179
            |   ..:..|.......||...::...||...::.:|:||:..|:||.|.....|.|||.:::.|
 Worm  2176 S---GINKGITAYTIGESSPRAVIRDSIGSLTIKSLAIDWINYNMYFINHDAERTNIEVSKLDGT 2237

Human  2180 YRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRS 2244
            ||::||....:.|..|.|||.:|||:|||.||:|.|:|||||.:.|.|:||.||..|..|.||.:
 Worm  2238 YRKILLTTKTETPSSIAVDPVSRYLYWADQGQKPTIQRSFLDGSRREVIVSSGIAEPTDLVVDVA 2302

Human  2245 DGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPEN 2309
            ...:||.|..:|.|.|:|..|...|::|  |...:..|:.:...::.|.|..|:|:|:|:.:|..
 Worm  2303 SKMIYWSDAKMDGIYRVRSTGGTPELVR--SDIASAAGVALHGQNMYWTDNRLEKLFRATSKPNQ 2365

Human  2310 TE---PPTVIRDNINWLRDVTIFDKQVQPR--SPAEVNNNPCLENNGGCSHLCFALPGLHTPKCD 2369
            |.   .||.:..::..:.||.:|....|||  ||.::.:|   .....|:.||||.||..||.|.
 Worm  2366 TSLLLSPTTVAASLKDIGDVAVFSSNNQPRASSPCQITDN---LRKSPCTQLCFATPGTQTPTCS 2427

Human  2370 CAFGTLQSDGKNCAISTENFLIFALSNSLRSLHLDPENHS-----PPFQTINVERTVMSLDYDSV 2429
            ||.|.|:  |:.|. ..:.:::|:..:.:..:.::|:..:     .||..|:   .:.:.|.|..
 Worm  2428 CARGVLK--GRTCE-EPDTYIMFSDGDKIIDVAIEPDVKASRPLKDPFPEIS---NLQTFDVDVN 2486

Human  2430 SDRIYFTQNLASGVGQISYATLSSGIHTPTVI--------ASGIGTADGIAFDWITRRIYYSDYL 2486
            ..|:||......|| .||:.::::. ..|.::        |..|.....:..||:|::||::...
 Worm  2487 LRRVYFVVESPVGV-NISWFSMNNA-ENPRLVFGASKQPHAKEIRHISDMKLDWLTQKIYFTTGR 2549

Human  2487 NQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGYLYWAD--WDT-----HAKIERATLGGNFRVP 2544
            ...:.::...|.:.:.||......|:.:|||.|.|:|:|  :.|     ..:|||:.|.|..|..
 Worm  2550 GGKVMAIDTAGEHLSTIASGDWTYALAIDPCSGLLFWSDSGYKTSGGLYEPRIERSNLAGGSRKV 2614

Human  2545 IVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLYGQYIYWTD 2609
            ||:.|:.:|:.:.:|:....:||.|.:...||.:...|.:|:||. :...|..|.::.:::|.:|
 Worm  2615 IVSESISLPAAIAVDFRNQKIYWADVNRLNIEVADYDGQNRKVIA-SGYRAKSLDIWDRWLYMSD 2678

Human  2610 LYTQRIYRANKYDGSGQIAMTTNLLSQPR--------GINTVVKNQKQQCN----NPCEQFNGGC 2662
            ..:..::|.:|..|||    ..|::|..|        ...:.|:.:.|.||    ..|:..||||
 Worm  2679 PLSNGVFRIDKESGSG----LENVVSDRRIPGALRVFASESDVRTRNQVCNALTSQLCKTDNGGC 2739

Human  2663 SHICAP-------GPNGAECQCPHEGNWYLANNRKHCIVDNGE----RC---GASS--------- 2704
            ..:|..       ..:..:|.|         |:....:.:.|:    :|   |::|         
 Worm  2740 DQLCTVVADDIGLAASKVQCSC---------NDTYELVQEPGKDYPTQCVLRGSNSEPAKECLPP 2795

Human  2705 --FTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCG 2767
              |.|.:|.||.....||:..||.|.|||..:.|...:|......|.|.||:..:.:|::.:|||
 Worm  2796 YNFQCGDGSCILLGATCDSKPDCADASDENPNYCNTRSCPEDYNLCTNRRCIDSAKKCNHIDDCG 2860

Human  2768 DGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEK--NCPDR--TCQSGYTK 2828
            |||||..|......|...|.|:|..||.:..:|:|.::|||...|||.  .||..  .|:....:
 Worm  2861 DGSDELDCPSAVACAEGTFPCSNGHCINQTKVCDGHNDCHDEQVSDESLATCPGLPIDCRGVKVR 2925

Human  2829 CHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDAS 2893
            |.|:||||....||||.:||||.:|||..:|....|:....:|.||||||:.|.||.:.||.|..
 Worm  2926 CPNTNICIQPADLCDGYDDCGDKADENQLFCMNQQCAQHYVRCPSGRCIPETWQCDGDNDCSDGW 2990

Human  2894 DEP-ASCGHS--ERTCLADE-FKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFL 2954
            ||. .:|..:  ::.|:.|. |:||..:||...:||||::||||.|||..||.|.|:.|:|.||.
 Worm  2991 DETHTNCTDTAGKKICVGDYLFQCDNLKCISRAFICDGEDDCGDGSDEHSRHGCGNRTCTDQEFH 3055

Human  2955 CVND---RPPDRRCIPQSWVCDGDVDCTDGYDEN-QNC--TRRTCSENEFTCGYGLCIPKIFRCD 3013
            |.::   ..|...|||::|:|||||.|..|.||: :.|  .::.|::.||.|....||...:.||
 Worm  3056 CTSNAKLAQPKYECIPRAWLCDGDVTCAGGEDESTELCKTEKKECNKGEFRCSNQHCIHSTWECD 3120

Human  3014 RHNDCGDYSDER-GCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPP 3077
            ..|||.|.|||. .|.|.:||.:.|.|.|.:|:..::.||.::||.||||         |..||.
 Worm  3121 GDNDCLDGSDEHANCTYSSCQPDFFQCANHKCVPNSWKCDGNDDCEDGSD---------EKDCPK 3176

Human  3078 H-------------EFKCDNGRCIEMMKLCNHLDDCLDNSDEKG-CGINECHDPSISGCDHNCTD 3128
            :             :|:|.:|.||:..|:|:...||.|.|||.. |.|:||.......|:..|.|
 Worm  3177 NSASAQKASKCSNGQFQCTSGECIDDAKVCDRNFDCTDRSDESSLCFIDECSLAEKPLCEQKCMD 3241

Human  3129 TLTSFYCSCRPGYKL-MSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTC- 3191
            ....:.|.|..|:.: :||:::|.:::||.|....|||||::.||||.|.|..||....|..:| 
 Worm  3242 MKIGYKCDCFEGFAIDISDQKSCHNVNECYEGISGCSQKCDDKIGSYKCGCVDGYQLSSDDHSCK 3306

Human  3192 RQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFL 3256
            |.....||:.:.:|::|:|.::|||..|.|..:|.||||:||.|..||:.|.||..:..:.|:.|
 Worm  3307 RTEMEPEPFFLLANKHYIRKISIDGNKYELAAQGFDNVVSLDIDLTEKKAYLIDQGKLRLLRVDL 3371

Human  3257 NK-----TNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANN 3316
            ::     ::.||::.|.:...|.:|||||.||||.|:.:...:.|.:|:|...:.|.:..:    
 Worm  3372 DEMDSPLSSYETVLRHNVYGTEGIAVDWVGRKLYMLNRQERSIRVCELDGRFCKTLIRDRI---- 3432

Human  3317 TFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNK-----SVIISTKLEWPNGITIDYTN 3376
                ..|:.:.:||..|||::.:|..:.||||:.:||:.:     ..:....|.|||.|.|||.:
 Worm  3433 ----QQPKAIVVHPGKGYLFFTEWSLQPYIGRIALDGSPELQDPIFKLAEHDLGWPNAIAIDYFS 3493

Human  3377 DLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNR 3441
            |.|:|.||||..|.:.|.:|:.|..:......|..::.:|:|.:||.|||.|.|.:.:|:.|.|.
 Worm  3494 DRLFWGDAHLNEIGFMDFDGNGRRHIPAQRTSHVSSMVVFDDYLYWADWNLREVLRCDKWTGKNE 3558

Human  3442 QTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGST 3506
            ..|..|...|.|:.:.||.|||...||||.|||||||||||..||.|:||.|||.|  :.||...
 Worm  3559 TILKKTVQLPNDLRIVHPMRQPAYPNPCGDNNGGCSHLCLIGAGGNGYTCSCPDQF--VLLSDQK 3621

Human  3507 YCMPMCSSTQFLCANNE-KCIPIWWKCDGQKDCSDGSDE--LALCPQRFCRLGQFQCSDGNCTSP 3568
            .|.|.|:..||.|..:: ||||..|.|||:.||.|||||  .::|.||.|.:|:|||::.|||.|
 Worm  3622 TCEPNCTERQFACGGDDAKCIPKLWYCDGEPDCRDGSDEPGESICGQRICPVGEFQCTNHNCTRP 3686

Human  3569 QTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQC-ANKRCIPESWQCDTFNDCEDNSDEDSSHC-- 3630
            ..:|:.:.:|.|.|||..  |:. .||...::| |..||||..:.||..:||.|.|||..:.|  
 Worm  3687 FQICDGNDDCGDSSDEQN--CDK-ACDPWMFKCAATGRCIPRRFTCDGDDDCGDRSDEADTLCMS 3748

Human  3631 ASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIE----ECMSSAHLCDNFTEFSCKTNYR 3691
            |.|.|...:|||.|.:||.:||:||.|:||||.|||..|    ||..      .:|.  |.::||
 Worm  3749 AERNCTAEEFRCNNNKCIAKAWRCDNDDDCGDGSDETPECAQIECKK------GWTR--CSSSYR 3805

Human  3692 CIPKWAVCNGVDDCRDNSDE--QGCEERTCHPVGDFRC-KNHHCIPLRWQCDGQNDCGDNSDE-- 3751
            |||.||.|||.|||||||||  |.|.  ||..||:||| .:..|||.||.||.:|||||||||  
 Worm  3806 CIPNWAFCNGQDDCRDNSDEDKQRCP--TCDDVGEFRCATSGKCIPRRWMCDTENDCGDNSDELD 3868

Human  3752 ENC--APRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSE 3814
            .:|  ..|.|:||||||.:.:|||...:||....|.|..||..|.:|.|.|.:.||..|.|:...
 Worm  3869 ASCGGTTRPCSESEFRCNDGKCIPGSKVCDGTIQCSDGLDESQCTLRRCLPGHRQCDDGTCIAEH 3933

Human  3815 LKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCL 3879
            ..||...||.:|:||..|..  .....|....|||.|.||||..:.||||:||||.|||....|.
 Worm  3934 KWCDRKKDCPNAADELHCED--VSRRTCSPFEFECANSVCIPRKFMCDGDNDCGDNSDETSSECR 3996

Human  3880 DVPCNSPNRFRCDNNR-CIYSHEVCNGVDDCG--DGTDETEEHCRKPTP-KPCTEYEYKCGNGHC 3940
            ...|:.|.||||.::| |:...::|||.:|||  |.:||....|...:. ..|:..::||.||.|
 Worm  3997 SAQCDPPLRFRCAHSRLCLNILQLCNGFNDCGPNDFSDEHLSMCSSFSEYGDCSSDQFKCANGKC 4061

Human  3941 IPHDNVCDDADDCGDWSDELGCNKGKERTCAENI-----CEQNCTQLNEGGFICSCTAGFETNVF 4000
            :.....||..|||||.|||:||:|...:|..|..     |:..||.:.: ||.|.|..||..:..
 Worm  4062 VNGTVACDRKDDCGDASDEIGCSKHGGKTSCEAFGNNGGCKHICTDVRD-GFYCHCRDGFRPDPQ 4125

Human  4001 DRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTS---MSDRPGKRCAAEGSSPLLLLPDN- 4061
            ....|:||:||....||.|.|.||||||.|.|.:.:.:   :....||.|.|:|.:..:::..: 
 Worm  4126 SPKECIDIDECAGNNTCTQLCLNTKGSYLCRCHEDYENNVVVGSMTGKDCRAKGDAANVMIGADD 4190

Human  4062 --VRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFE 4124
              |::..:...:.|.:....:::....:...:||:.   .::|:.   :||. ..|.|:.|.|..
 Worm  4191 SLVQLSLHGSGTNRHAAAKANDDDNDIIGIAFDPRK---ELMYWI---DGSE-RTIYRSAIANGN 4248

Human  4125 SGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDV-----------KNKR------------I 4166
            ........:||.....|: |..||||:...:::.:.|           :.||            |
 Worm  4249 QSHEGQKLDVDFAAMGVV-PTAIAVDYTTGNLFIAAVSENIENGLVTARKKRMSEPIDNQNTGFI 4312

Human  4167 EVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWP 4231
            .|...||||.|.:::..|.||.|:...|..|.:.::|.|...|||.|.|:|..|.|:|.:.:..|
 Worm  4313 FVCLPDGRYLKKIVAGHLQQPTALITAPSAGRICYSDAGLHAKIECADMDGTHRQIIVKDLVFSP 4377

Human  4232 TGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWK 4296
            |.::||....:||||.|.|...::.:..||::|..:..:...||::|:||:.:||:|:|...::.
 Worm  4378 TSMAIDEGKGNRIYWVDPKYRRVDAVNIDGSERTTVVHDRHIPYAVDVFENHIYWLSRESKTLYV 4442

Human  4297 QNKFGQGKKEKTLVVNPWLTQVRIFHQLRYN--------KSVPNLCKQICSHLCLLRPG-GYSCA 4352
            |:|||:|:      |:...:.:...|.:|.:        ::|....:..|||||:..|. |::|.
 Worm  4443 QDKFGRGR------VSVLASDLEDGHTVRVSQKYAKDTQRTVSGCERAQCSHLCVSLPSTGFACL 4501

Human  4353 CPQG-SSFIEGS--TTECDAAIELPINLPPPCRCMHGGNCYFDETDLPKCKCPSGYTGKYC--EM 4412
            ||.| ...::||  |...:|     :.:|..|:|.:||.|..|.:    |:|.|.:.|..|  |.
 Worm  4502 CPDGIVPQLDGSCATQHVEA-----LTMPKQCKCTNGGKCRLDGS----CECTSDFEGDQCEKES 4557

Human  4413 AFSKGISPGTTA---VAVLLTIL-LIVVIGALAIAGFFHYRRTGSLLPALPKLPSLSSLVKPSEN 4473
            :.|:.|. ||.:   :.|||.|| .:...|.:.......|:|.             ..|.|.:|.
 Worm  4558 SVSRKII-GTLSENFITVLLYILAFLFAFGLIGFCALNLYKRR-------------QLLFKKNEA 4608

Human  4474 GNG-VTFRSGADLNMDIGVSGFGPETAIDRSMAMSEDFVME----MGKQPIIFENPMYSARDSAV 4533
            .:| |:|..        .|..|......::..|...:|.|:    |......|.||:|..     
 Worm  4609 ADGSVSFHG--------NVISFSNPVLENKQDAPGSEFNMQQMTSMHDDSTTFTNPVYEL----- 4660

Human  4534 KVVQPIQVTVSENVDNKNYGSPINPSEIVPETNPT--SPAADGTQVTKWNLFKRKSKQTTNFENP 4596
                       |:||   ..|| .||...|.|:.:  ||....|..            .::|..|
 Worm  4661 -----------EDVD---MSSP-PPSNDQPSTSASAMSPNRPSTSA------------ASSFVPP 4698

Human  4597 IYAQMENEQKES-------VAATPPPSPSLPAKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSE 4654
            .:.|.|.|.|.:       ...:.||.|:.|.|.|....|...|.|.              .|||
 Worm  4699 TFDQDEIELKTADEIIVPKAEISKPPIPARPKKEKADPLRVDNPLYD--------------PDSE 4749

Human  4655 V 4655
            |
 Worm  4750 V 4750

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP2NP_004516.2 LDLa 28..62 CDD:238060 17/33 (52%)
LDLa 108..142 CDD:238060 13/34 (38%)
LDLa 149..179 CDD:238060 14/34 (41%)
LDLa 183..217 CDD:238060 15/35 (43%)
LDLa 222..256 CDD:238060 15/33 (45%)
LDLa 266..300 CDD:238060 16/33 (48%)
YncE 394..579 CDD:442618 63/196 (32%)
LDL-receptor class B 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 436..478 15/45 (33%)
LDL-receptor class B 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 479..521 16/41 (39%)
LY 503..548 CDD:214531 17/44 (39%)
LDL-receptor class B 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 522..568 17/45 (38%)
LY 551..591 CDD:214531 16/39 (41%)
LDL-receptor class B 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 569..613 21/43 (49%)
FXa_inhibition 663..704 CDD:464251 14/40 (35%)
LDL-receptor class B 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 753..795 10/41 (24%)
LY 776..818 CDD:214531 12/49 (24%)
LDL-receptor class B 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 796..837 16/48 (33%)
LDL-receptor class B 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 838..881 19/42 (45%)
Ldl_recept_b 838..879 CDD:459654 18/40 (45%)
LY 864..904 CDD:214531 18/39 (46%)
LDL-receptor class B 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 882..925 11/42 (26%)
FXa_inhibition 981..1013 CDD:464251 9/39 (23%)
LDLa 1026..1060 CDD:238060 19/40 (48%)
LDLa 1067..1101 CDD:238060 15/36 (42%)
LDLa 1109..1143 CDD:238060 21/35 (60%)
LDLa 1149..1183 CDD:238060 18/35 (51%)
LDLa 1187..1222 CDD:238060 18/34 (53%)
LDLa 1230..1264 CDD:238060 18/33 (55%)
LDLa 1271..1305 CDD:238060 20/45 (44%)
LDLa 1311..1344 CDD:197566 11/32 (34%)
FXa_inhibition 1353..1388 CDD:464251 14/34 (41%)
EGF_CA 1390..1429 CDD:214542 18/38 (47%)
LY 1461..1500 CDD:214531 17/38 (45%)
LDL-receptor class B 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1478..1520 18/41 (44%)
LY 1501..1543 CDD:214531 21/42 (50%)
LDL-receptor class B 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1521..1563 22/42 (52%)
LY 1545..1589 CDD:214531 23/43 (53%)
LDL-receptor class B 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1566..1609 23/42 (55%)
LY 1591..1632 CDD:214531 18/40 (45%)
LDL-receptor class B 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1610..1654 21/43 (49%)
LDL-receptor class B 13. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1655..1695 13/46 (28%)
YvrE 1787..>1951 CDD:442613 45/175 (26%)
LDL-receptor class B 14. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1790..1832 10/53 (19%)
LDL-receptor class B 15. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1833..1882 18/48 (38%)
LDL-receptor class B 16. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1883..1930 13/46 (28%)
Ldl_recept_b 1883..1928 CDD:459654 12/44 (27%)
LY 1911..1953 CDD:214531 8/41 (20%)
LDL-receptor class B 17. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1931..1972 11/41 (27%)
LDL-receptor class B 18. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1973..2013 12/47 (26%)
FXa_inhibition 2022..2058 CDD:464251 10/35 (29%)
YncE <2091..2252 CDD:442618 61/160 (38%)
LDL-receptor class B 19. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2107..2156 11/48 (23%)
LDL-receptor class B 20. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2157..2201 18/43 (42%)
LDL-receptor class B 21. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2202..2245 25/42 (60%)
LY 2227..2267 CDD:214531 17/39 (44%)
Vgb 2236..2544 CDD:443399 91/332 (27%)
LDL-receptor class B 22. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2246..2289 12/42 (29%)
LDL-receptor class B 23. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2431..2477 12/53 (23%)
LY 2459..2500 CDD:214531 8/48 (17%)
LDL-receptor class B 24. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2478..2518 8/39 (21%)
LY 2500..2542 CDD:214531 16/48 (33%)
LDL-receptor class B 25. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2519..2562 16/49 (33%)
LY 2545..2585 CDD:214531 11/39 (28%)
LDL-receptor class B 26. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2563..2604 11/40 (28%)
LY <2593..2625 CDD:214531 7/31 (23%)
LDL-receptor class B 27. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2605..2646 11/48 (23%)
FXa_inhibition 2655..2692 CDD:464251 9/43 (21%)
LDLa 2700..2732 CDD:238060 15/45 (33%)
LDLa 2741..2775 CDD:238060 14/33 (42%)
LDLa 2784..2817 CDD:238060 13/34 (38%)
LDLa 2821..2854 CDD:197566 15/32 (47%)
Ldl_recept_a 2863..2895 CDD:395011 14/31 (45%)
LDLa 2905..2937 CDD:197566 16/32 (50%)
LDLa 2948..2988 CDD:238060 19/43 (44%)
LDLa 2993..3027 CDD:238060 15/34 (44%)
LDLa 3031..3063 CDD:197566 13/31 (42%)
LDLa 3075..3109 CDD:238060 15/47 (32%)
FXa_inhibition 3121..3150 CDD:464251 8/29 (28%)
vWFA <3147..3190 CDD:469594 18/42 (43%)
LY 3219..3260 CDD:214531 17/45 (38%)
LDL-receptor class B 28. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3239..3281 14/46 (30%)
LY 3262..3304 CDD:214531 17/41 (41%)
Ldl_recept_b 3282..3330 CDD:459654 10/47 (21%)
LDL-receptor class B 29. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3282..3324 9/41 (22%)
LDL-receptor class B 30. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3333..3376 18/47 (38%)
Ldl_recept_b 3333..3374 CDD:459654 16/45 (36%)
LY 3358..3399 CDD:214531 18/40 (45%)
LDL-receptor class B 31. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3377..3419 13/41 (32%)
LY <3408..3441 CDD:214531 12/32 (38%)
LDL-receptor class B 32. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3420..3460 15/39 (38%)
FXa_inhibition 3469..>3498 CDD:464251 21/28 (75%)
LDLa 3512..3544 CDD:197566 17/32 (53%)
LDLa 3553..3584 CDD:197566 13/30 (43%)
LDLa 3594..3626 CDD:238060 15/32 (47%)
LDLa 3634..3666 CDD:197566 17/31 (55%)
LDLa 3682..3714 CDD:238060 22/33 (67%)
LDLa 3719..3754 CDD:238060 22/37 (59%)
LDLa 3759..3793 CDD:238060 16/33 (48%)
LDLa 3798..3832 CDD:238060 13/33 (39%)
LDLa 3885..3915 CDD:197566 14/32 (44%)
LDLa 3928..3962 CDD:238060 16/33 (48%)
EGF_CA 4007..4047 CDD:214542 18/42 (43%)
LY 4141..4176 CDD:214531 14/57 (25%)
LDL-receptor class B 33. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4154..4196 15/64 (23%)
LDL-receptor class B 34. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4197..4240 16/42 (38%)
Ldl_recept_b 4197..4238 CDD:459654 15/40 (38%)
LY 4222..4264 CDD:214531 14/41 (34%)
LDL-receptor class B 35. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4242..4283 14/40 (35%)
FXa_inhibition 4338..>4356 CDD:464251 10/18 (56%)
SH3-binding. /evidence=ECO:0000255 4453..4462 0/8 (0%)
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4456..4461 0/4 (0%)
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4459..4464 0/4 (0%)
Endocytosis signal. /evidence=ECO:0000255 4521..4526 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4550..4574 8/25 (32%)
Interaction with DAB2. /evidence=ECO:0000269|PubMed:10769163 4589..4602 3/12 (25%)
NPXY motif 4595..4598 1/2 (50%)
SH2-binding. /evidence=ECO:0000255 4598..4601 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4601..4655 14/60 (23%)
SH3-binding. /evidence=ECO:0000255 4611..4622 4/10 (40%)
lrp-1NP_001379135.1 LDLa 53..87 CDD:238060 17/33 (52%)
LDLa 92..131 CDD:238060 18/75 (24%)
LDLa 140..173 CDD:238060 14/32 (44%)
LDLa 182..216 CDD:238060 15/33 (45%)
LDLa 223..257 CDD:238060 15/33 (45%)
LDLa 262..297 CDD:238060 16/40 (40%)
YncE <376..564 CDD:442618 60/204 (29%)
LY 547..589 CDD:214531 16/41 (39%)
LY 883..925 CDD:214531 18/41 (44%)
LDLa 1057..1087 CDD:197566 16/29 (55%)
LDLa 1100..1133 CDD:197566 13/32 (41%)
LDLa 1146..1177 CDD:197566 18/30 (60%)
LDLa 1187..1219 CDD:238060 17/31 (55%)
LDLa 1228..1263 CDD:238060 18/34 (53%)
LDLa 1270..1302 CDD:238060 16/31 (52%)
LDLa 1313..1344 CDD:238060 18/30 (60%)
FXa_inhibition 1447..1475 CDD:464251 14/27 (52%)
LY 1511..1545 CDD:214531 16/36 (44%)
LY 1548..1585 CDD:214531 20/36 (56%)
LY 1590..1634 CDD:214531 25/45 (56%)
LY 1635..1677 CDD:214531 18/41 (44%)
Vgb <1921..2043 CDD:443399 34/122 (28%)
LY 2193..2239 CDD:214531 14/45 (31%)
LY 2240..2283 CDD:214531 22/42 (52%)
LY 2284..2325 CDD:214531 17/40 (43%)
Ldl_recept_b 2582..2629 CDD:459654 15/46 (33%)
LY 2613..2655 CDD:214531 11/41 (27%)
LDLa 2794..2824 CDD:197566 11/29 (38%)
LDLa 2834..2868 CDD:238060 14/33 (42%)
LDLa 2874..2907 CDD:197566 12/32 (38%)
LDLa 2961..2994 CDD:238060 16/32 (50%)
LDLa 3012..3038 CDD:238060 14/25 (56%)
LDLa 3048..3088 CDD:197566 17/39 (44%)
LDLa 3099..3131 CDD:197566 13/31 (42%)
LDLa 3140..3174 CDD:238060 15/42 (36%)
LDLa 3186..3218 CDD:197566 11/31 (35%)
FXa_inhibition 3276..3305 CDD:464251 14/28 (50%)
LY 3382..3424 CDD:214531 17/41 (41%)
Ldl_recept_b 3445..3491 CDD:459654 16/45 (36%)
LY 3476..3516 CDD:214531 18/39 (46%)
FXa_inhibition 3586..3623 CDD:464251 24/38 (63%)
LDLa 3627..3660 CDD:197566 17/32 (53%)
LDLa 3671..3705 CDD:238060 15/35 (43%)
LDLa 3792..3825 CDD:197566 21/40 (53%)
LDLa 3837..3868 CDD:238060 20/30 (67%)
LDLa 3878..3912 CDD:238060 16/33 (48%)
LDLa 3917..3951 CDD:238060 13/33 (39%)
LDLa 3958..3990 CDD:197566 18/31 (58%)
LDLa 4049..4083 CDD:238060 16/33 (48%)
FXa_inhibition 4097..>4121 CDD:464251 8/24 (33%)
EGF_CA 4132..4163 CDD:214542 16/30 (53%)
NHL 4219..>4431 CDD:302697 62/219 (28%)
NHL repeat 4219..4257 CDD:271332 9/44 (20%)
NHL repeat 4267..4330 CDD:271332 15/62 (24%)
NHL repeat 4333..4371 CDD:271332 14/37 (38%)
NHL repeat 4373..4410 CDD:271332 12/36 (33%)

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