DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRP2 and lrp2

DIOPT Version :10

Sequence 1:NP_004516.2 Gene:LRP2 / 4036 HGNCID:6694 Length:4655 Species:Homo sapiens
Sequence 2:XP_012826499.2 Gene:lrp2 / 100489914 XenbaseID:XB-GENE-486052 Length:4662 Species:Xenopus tropicalis


Alignment Length:4668 Identity:3225/4668 - (69%)
Similarity:3847/4668 - (82%) Gaps:26/4668 - (0%)


- Green bases have known domain annotations that are detailed below.


Human     1 MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVV 65
            |.|..|.:|..||....  :..|..|.|.|..|||.:|.|||..||||||.||:|::||.||...
 Frog     8 MQRPVALLALGLLFTFY--IQKAHSQTCSSGSFRCSNGRCIPLSWRCDGTADCTDNSDEAGCPPR 70

Human    66 TCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHV 130
            ||....|:| .:|.||.:|||||.::|||||||| |.|...|||:.|.|||:|||||..||||.:
 Frog    71 TCSTSQFRC-GDGDCITSSWVCDDEEDCDDGSDE-QHCPGRTCSAQQFTCSSGQCIPRAYRCDRM 133

Human   131 RDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGEC 195
            :||.|||||.:|.||.|.:|:|.:|||||.||:||..|||||||||.|||:.||.::|.|.:|||
 Frog   134 KDCTDGADERNCLYPVCTELSCGSGACYNRSQRCDGIVDCRDSSDESNCTQRCLSSQFQCPSGEC 198

Human   196 IPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGP 260
            |||.::||||:||.|.|||..|.||||.|..|||.:||||:|.|:|||:|||.|||||.|||.|.
 Frog   199 IPRDFLCDHDDDCGDESDEKNCTYPTCRGDYFTCSNGRCIHQTWLCDGDDDCDDNGDEWGCEGGH 263

Human   261 HDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETP 325
            .:   |.|.||:||.||:||.:.||||||:.|...|||:|.:.|:.||...|::|:||::||.:|
 Frog   264 RE---CGPGEWACPSSGQCIPVDKVCDGIVHCRFGEDESNITAGRNCSTNNCASLSCQHRCHSSP 325

Human   326 YGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKANDS 390
            .||.|:||.||:|:.||||||::||||::||||||.||.|.|.:.|.|.||||||..::|:||.:
 Frog   326 AGGLCYCPAGYVISSNDSRTCIDFDDCKMWGICDQFCEDRIGSYRCSCAEGYILEHHKHCRANST 390

Human   391 FGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDING 455
            .|..|||||||||||||||||.:.||||:|.||||||||.||:.|:|||||||||||||||||:|
 Frog   391 RGPPSIIFSNGRDLLIGDIHGGNSRILVQSHNRGVAVGVDFHFQLRRVFWTDTVQNKVFSVDIDG 455

Human   456 LNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPT 520
            .|::||||:|:|||||||||||:||||:|||.:.|||||:|||..|:|||.|:||:|||||:||:
 Frog   456 SNVREVLNISIETPENLAVDWVSNKIYVVETSIKRIDMVDLDGQNRITLIAEDLGNPRGIALDPS 520

Human   521 VGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVT 585
            |||||||||.|.|.|.|||||||||:||.|::|||||||||:|||:|:||:||||||:|||||.|
 Frog   521 VGYLFFSDWGSNSEESKLERAFMDGTNRHDIIKTKLGWPAGMTLDIITKRLYWVDSRYDYIETTT 585

Human   586 YDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTV 650
            |||:.|:||||||::||||:|:|:||..::||||||::|:||||||:.:.||.|::|.|||||||
 Frog   586 YDGLDRRTVVHGGNVIPHPYGLSIFEHYLYFTDWTKVSVMKANKFTDNSTQVVYRSSSRPYGVTV 650

Human   651 YHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSS 715
            |||.||||..|||..|||||||:|||||||||.|||:||:|..||.|..|.|.|:.|:.||:|||
 Frog   651 YHSARQPYVRNPCGTNNGGCEQICVLSHRTDNGGLGYRCRCKLGFDLHEDGRRCVVVRKFLLFSS 715

Human   716 QVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAA 780
            |:|:|||||.|||||||::|::|.||:||||||||||:.||:||..|.||:|||.||||:|||.|
 Frog   716 QLAVRGIPFNLSTQEDVIIPITGVPSYFVGIDFDAQDNAIFYSDTVKDMIYKQKTDGTGKEILTA 780

Human   781 NRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDW 845
            ||||.||.||:|||||||||||..|:|||||:||||:||.::|.||||||:||||..||:|:|||
 Frog   781 NRVEGVEDLAYDWISKNLYWTDPRYRSISVMKLADKSRRAIIQNLNNPRSIVVHPVIGYIFWTDW 845

Human   846 FRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHI 910
            :|||||||||.|||||.|::|::||||||||:||::.|||||||:|||:||||||||||:.|..|
 Frog   846 YRPAKIMRAWCDGSHLQPIVNSSLGWPNGLAMDWSSLRLYWVDAFFDKVEHSTFDGLDRQTLNRI 910

Human   911 EQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACN 975
            .||||||||.|:|.:.:.||||||.|:||||.||||||:||.||..|:|:||:|.:.|.|||.||
 Frog   911 TQMTHPFGLTIYGGYAYITDWRLGGIVRVRKYDGGEMTIIRRGINNIMHVKSFDASTQIGSNYCN 975

Human   976 QPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVP 1040
            :||:|||||||||:||||.||||||||||||..:..||..||.:||||.|||.:||||.||:|||
 Frog   976 RPTNPNGDCSHFCYPVPNLQRVCGCPYGMRLRPDQQTCFDDPASEPPTMQCGSYSFPCANGKCVP 1040

Human  1041 NYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHA 1105
            .|..|||||||||||||..|||.||||||.|||||:|:|||.:||||..|||||.|||.||||..
 Frog  1041 VYDRCDGVDDCHDNSDEANCGTRNNTCSSRAFTCGNGQCIPLNWRCDGHNDCVDRSDEQNCPTQG 1105

Human  1106 PASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDG 1170
            |.||..|.:||.|::||.:.|:|||||||||||||.|||.|.||:|.||.||:|||||.|:||||
 Frog  1106 PRSCSSTSFTCQNNRCIPRIWLCDTDNDCGDGSDELNCNFTSTCEPGQFQCPDHRCIDPSYVCDG 1170

Human  1171 DKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEF 1235
            ||||||||||:||..||:.|:|||||||:||....:|||||||:|:|||..|||||.||||.:||
 Frog  1171 DKDCVDGSDEMGCTYNCSYSEFKCASGDQCISTGYQCDGVFDCNDHSDELNCPTRPAGMCHQNEF 1235

Human  1236 QCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMS 1300
            |||.||.|||:.|||||||||:.||||||.|..::||.|.|.|||||||:|:|:||.||||.|||
 Frog  1236 QCQSDGACIPSNWECDGHPDCIDGSDEHNTCPVRSCPPSMFRCDNGNCIYRSWICDGDNDCRDMS 1300

Human  1301 DEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCN-----GNSCSDFNGGC 1360
            |||||||.|||||||||||.|:.||:|:|.|||...|||||.|||||||     ..||:|.|.||
 Frog  1301 DEKDCPTPPFRCPSWQWQCPGNTICINVSKVCDNTPDCPNGADESPLCNEYQPDQESCTDNNAGC 1365

Human  1361 THECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDG 1425
            ||:|:|.||||:|.||.|:.|:|||||||||:||...|.|||.|||.|||:||.|:.||:||.:|
 Frog  1366 THQCIQGPFGAQCTCPEGYSLSNDSKTCEDINECLTPGFCSQTCYNERGSYRCYCEDGYILEPNG 1430

Human  1426 RTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKT 1490
            ||||...|.:|||||||:|:||||::|:|.||||.::.:|..|||:||||::.||||||..|.|.
 Frog  1431 RTCKAAGSANLLLLVASRNQIIADNITTQAHNIYPVIRDGRTIVAIDFDSVTNRIFWSDIAQDKI 1495

Human  1491 WSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPR 1555
            ||||.|||||:|:|||.:.:||:||:||||||||||||.|||||||::||:|||||||:|:||||
 Frog  1496 WSAFVNGTDRKVIFDSGVTVTESIAVDWVGRNLYWTDYVLETIEVSQLDGTHRTVLISENVTNPR 1560

Human  1556 GLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLD 1620
            ||.||||.:.|::||:|||.:||||||||||.||||||.:||:||.||.|||||:.|||.|:|||
 Frog  1561 GLVLDPRTDAHVMFWTDWGRNPRIERASMDGKMRTVIVSNKIYWPNGLAIDYPNKRLYFADAYLD 1625

Human  1621 YMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQW 1685
            |:|:|||:|::|:|.:||||:::||:|:|:|||.||||||.|.||:||||:|||||:|::|||..
 Frog  1626 YIDYCDYDGNNRKQAMASDLVLQHPHAITIFEDYVYWTDRYTSRVIRANKFHGGNQTVMIYNIHQ 1690

Human  1686 PLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLIT 1750
            ||||.|||..|||..||||||:.|||:|||||.||.||||.|||||:|..|.:||.||::|||:.
 Frog  1691 PLGISAVHSVKQPGGVNPCAFNPCSHICLLSSIGPKFYSCACPSGWTLVSDSVNCQRDEKPFLVV 1755

Human  1751 VRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGEIHRVKTDGTNRTVFA 1815
            ||..||||:||||:.|:||||||:|||:||.||:|||:||.|||:||||||||||:|||||||||
 Frog  1756 VRDSIIFGMSLNPDDKTNDAMVPVAGIRNGYDVDFDDSEQMIYWIENPGEIHRVKSDGTNRTVFA 1820

Human  1816 SISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDP 1880
            ..:::|..:.|||||||.|||.||||||||||:.|.|::::|||||.||||..|.|.||||.|||
 Frog  1821 PAAIIGAPVGLALDWISGNLYYTNPRTQSIEVIKLRGEVKHRKTLITNDGTQTGAGAPIGIAVDP 1885

Human  1881 ARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIER 1945
            ||||:||:|||.|.|.|||:|||:|||::...|||.||:|:|.:|:|..||||||.|||.|:|||
 Frog  1886 ARGKMYWTDQGIDGGTPAKVASADMDGSNPSVLFTNNLDHIEFITIDTAEQKLYWTVTGTGMIER 1950

Human  1946 GNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVY 2010
            ||:|||:|:.:|:.||||||||:|::||||:|..|||||||||:|||||:|:|||:..|:.|:|:
 Frog  1951 GNMDGTNRVTVVNHLSHPWGIAIHEAFLYYSDRDYEVIERVDKSTGANKVVMRDNIQGLKCLRVH 2015

Human  2011 HRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRG 2075
            :|.|:|.||||||||.:||||:|.|.|.|.|||:||||||:|.|||:||||:||||||||:||:|
 Frog  2016 YRDNSAGSSNGCSNNPDACQQLCFPKPQGQFSCSCATGFKINADNRTCSPYSSFIVVSMLTAIKG 2080

Human  2076 FSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTH 2140
            ||||.:||||.|||:||:|||||||||.:.||:||||||||:..::|.|||:||:|||..||||.
 Frog  2081 FSLEAADHSEAMVPMAGRGRNALHVDVHMPSGYIYWCDFSSTPGANNGIRRVKPNGSSFRNIVTG 2145

Human  2141 GIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLF 2205
            |||.||:||||||||||||||||||::||.|||||:||:|||||:|.||||||||||||||||:|
 Frog  2146 GIGRNGIRGIAVDWVAGNLYFTNAFLTETFIEVLRLNTSYRRVLMKTTVDMPRHIVVDPKNRYIF 2210

Human  2206 WADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEV 2270
            ||||||.|||||:|||||||||||||||||||||||||::|||||||||||:|||::..|..:|:
 Frog  2211 WADYGQSPKIERAFLDCTNRTVLVSEGIVTPRGLAVDRTNGYVYWVDDSLDMIARVKSEGGETEI 2275

Human  2271 IRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQP 2335
            :||||||||||||||||||||||||||||||||||||.|:|.|:|||||||.|||||:||.:.||
 Frog  2276 VRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPSNSEQPSVIRDNINLLRDVTVFDSRYQP 2340

Human  2336 RSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRS 2400
            .||.|:|||||.:||||||||||||||..|.||.||:|||.|||..|.|||:::|||||..|:||
 Frog  2341 TSPQELNNNPCFQNNGGCSHLCFALPGQQTRKCGCAYGTLASDGTRCVISTDDYLIFALEGSIRS 2405

Human  2401 LHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGI 2465
            |.||||||||||..:||.||.::|||||:.:|:||||:..:|..:|||.:|||.....|.:||.:
 Frog  2406 LLLDPENHSPPFPPVNVFRTAVALDYDSLDNRVYFTQSSGAGRSRISYFSLSSPSGPRTTVASDL 2470

Human  2466 GTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGYLYWADWDTHA 2530
            |..||||||||.:|:||||||||.|||||.:||:|||||||.:||||:||||:||:||.||.|:|
 Frog  2471 GAPDGIAFDWIHKRVYYSDYLNQTINSMAVNGSDRTVIARVQRPRAIMLDPCRGYMYWTDWGTNA 2535

Human  2531 KIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHA 2595
            ||||||||||||..|||:|||.|:||||||||:.|||.||:||:|||.:|||.:|||:|:.||:.
 Frog  2536 KIERATLGGNFRTAIVNTSLVWPNGLTLDYEEERLYWADANLQKIERCSLTGTNREVVVSTAVYP 2600

Human  2596 FGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNG 2660
            |.:|||.|:|||||..|:.||||||:|||.||.|..||..:|..|:.:.||::|||::||:||||
 Frog  2601 FAMTLYDQHIYWTDWNTRSIYRANKHDGSDQIIMIQNLPQRPMDIHVLSKNKQQQCSSPCDQFNG 2665

Human  2661 GCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDC 2725
            ||||||||||||||||||..|.||||||.|.||||||.||....|||.|||||.|..||||||||
 Frog  2666 GCSHICAPGPNGAECQCPASGRWYLANNNKDCIVDNGTRCENGKFTCLNGRCIPERHKCDNDNDC 2730

Human  2726 GDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNN 2790
            .|||||:|.|||.|||..|:|||.|||||.|.||||:||||||.|||.|||||.|:..|||.|||
 Frog  2731 RDGSDELERVCAFHTCPSTSFTCGNGRCVPYHYRCDHYNDCGDNSDELGCLFRTCDPNTEFTCNN 2795

Human  2791 RRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDEN 2855
            .|||.|.::||||:||.||.||||:||||||||.|||||.::||||||.|||||||||||.|||:
 Frog  2796 GRCISRAYVCNGVNNCFDNGTSDERNCPDRTCQPGYTKCRSTNICIPRTYLCDGDNDCGDMSDES 2860

Human  2856 PTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIP 2920
            ||:|.|.||:.|||:|:||||||.||||||..||.|.||||.:|....|||.:|:|:||..||||
 Frog  2861 PTHCVTLTCTESEFRCSSGRCIPGHWYCDQGVDCSDGSDEPPTCVAHVRTCSSDQFRCDDARCIP 2925

Human  2921 SEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDEN 2985
            :.||||||||||||||||:||.|.|::|:.:||.|:|:|||:|||||||||||||.||:|.|||:
 Frog  2926 ASWICDGDNDCGDMSDEDQRHNCANRSCAPTEFTCINNRPPERRCIPQSWVCDGDADCSDAYDEH 2990

Human  2986 QNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFV 3050
            ||||||:||.:||.|..|||:...|||||.|||||.||||||:|.||||.||||||||||||.||
 Frog  2991 QNCTRRSCSSSEFACANGLCVRSNFRCDRRNDCGDGSDERGCIYPTCQQQQFTCQNGRCISKAFV 3055

Human  3051 CDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECH 3115
            ||.||||||.||||.|.|.|.|.||.||.|||||..||....:||..|||.||||||.||||||:
 Frog  3056 CDGDNDCGDESDELEHTCTTSEATCNPHYFKCDNLICIAQGSVCNGNDDCGDNSDEKACGINECN 3120

Human  3116 DPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAP 3180
            ||||||||||||||.|||:|:|||||:||||||||.|||||:|.|.||||.|||..|||||||||
 Frog  3121 DPSISGCDHNCTDTQTSFFCTCRPGYRLMSDKRTCDDIDECSETPSVCSQICENTAGSYICKCAP 3185

Human  3181 GYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWID 3245
            ||:|||:|:.|||||||.||||||||||||||::||..|||||:||..|.||||||||.||||||
 Frog  3186 GYIREPNGRNCRQNSNINPYLIFSNRYYLRNLSLDGQSYSLILQGLSIVAALDFDRVESRLYWID 3250

Human  3246 TQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQH 3310
            ..|:||||||||.||||||||:.:||.|.|||||:.||:||||:..|.|.|:||:|..|:.|...
 Frog  3251 AGRRVIERMFLNGTNKETIINNDIPAGEGLAVDWIGRKIYWLDSYKDCLNVADLDGRFRKKLIDR 3315

Human  3311 CVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYT 3375
            |:||||||||..||.:.:||:.||:||.||..:.:|||.||||.||:||||||:|||||:|||||
 Frog  3316 CIDANNTFCFQYPRAIVVHPKKGYVYWTDWADKPFIGRAGMDGKNKTVIISTKIEWPNGLTIDYT 3380

Human  3376 NDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSN 3440
            ||:||||||||.|||||||:|.||||||||.||||||||:|||.||||||||||||||||||||.
 Frog  3381 NDMLYWADAHLNYIEYSDLDGRHRHTVYDGNLPHPFAITVFEDNIYWTDWNTRTVEKGNKYDGSG 3445

Human  3441 RQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGS 3505
            |..|.|||||||||||||||||||.:||||.||||||||||||.||:|:||||||:|..:|....
 Frog  3446 RTMLANTTHRPFDIHVYHPYRQPITNNPCGRNNGGCSHLCLIKEGGQGYTCECPDNFLAVQFGSV 3510

Human  3506 TYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQT 3570
            ..|:|.|||||||||::|:|||||||||||:||.|||||.|.||||:||:|||||:||||||...
 Frog  3511 VRCLPACSSTQFLCADSERCIPIWWKCDGQRDCRDGSDEPATCPQRYCRVGQFQCNDGNCTSSFF 3575

Human  3571 LCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTC 3635
            :||::.:||||||||::||.||.||:::||||||||||||||||..:||.|||||||:||::|||
 Frog  3576 MCNSYPDCPDGSDEDQILCANHQCDTHQWQCANKRCIPESWQCDQEDDCGDNSDEDSAHCSTRTC 3640

Human  3636 RPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCN 3700
            .||||||.|||||||:||||||:|||||||||.:|||..|:.|||.|:|.|:|||||:|.|:|||
 Frog  3641 NPGQFRCNNGRCIPQSWKCDVDDDCGDHSDEPFQECMGPAYRCDNHTDFDCRTNYRCVPMWSVCN 3705

Human  3701 GVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFR 3765
            |.|||||||||||||:|||.|.|||||.||.||||||:|||.|||.|.|||.||:||||||||||
 Frog  3706 GYDDCRDNSDEQGCEQRTCDPRGDFRCDNHRCIPLRWKCDGDNDCNDGSDERNCSPRECTESEFR 3770

Human  3766 CVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEA 3830
            |.|.:|||.||||||.|||.|||||||||:|||||.||||.||||:....:|||:|||||.||||
 Frog  3771 CDNLRCIPGRWICDHDNDCEDNSDERDCEIRTCHPGYFQCNSGHCIAERFRCDGTADCLDVSDEA 3835

Human  3831 DCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNR 3895
            .||||:|:|.||.|:||||||||||.|||:||||:||||||||||..|||:||..|.||||.|||
 Frog  3836 ACPTRYPNGTYCPASMFECKNHVCIQPYWRCDGDNDCGDGSDEELQHCLDIPCEPPFRFRCGNNR 3900

Human  3896 CIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDEL 3960
            |:|.||:|||||||.||:|||||.||.|||:|||:.||||||..|:|...||||.|||||.|||.
 Frog  3901 CVYRHEICNGVDDCSDGSDETEEQCRPPTPRPCTDEEYKCGNHFCVPLHYVCDDYDDCGDHSDEA 3965

Human  3961 GCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTK 4025
            |||:|.:|:|:|||||.|||.|:||||||||..|::.:..||.||.||||||.:..|||.|:|:|
 Frog  3966 GCNRGTQRSCSENICEHNCTNLSEGGFICSCRPGYKASESDRNSCEDINECELYRKCPQDCKNSK 4030

Human  4026 GSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYD 4090
            |||||.||:|:.|:.|:.|.:|||||:.||||||||||||:||||||::|:|::|::::||:|||
 Frog  4031 GSYECFCAEGYRSVGDQQGTQCAAEGTPPLLLLPDNVRIRRYNLSSEQYSDYIEDQQHVQALDYD 4095

Human  4091 WDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRH 4155
            |||:.||||||||::||:||.||:|:|||:|.||...||||::|||.|:|:..|||:||||||||
 Frog  4096 WDPEGIGLSVVYYSIRGQGSTFGSIRRAYLPTFEDYGNNLVKDVDLDLRYIGNPDGLAVDWVGRH 4160

Human  4156 IYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDR 4220
            |||:|....||||||||||||||||.|.:||||||.|||:||.|:|||||::||||.|||:|:.|
 Frog  4161 IYWTDAGTNRIEVAKLDGRYRKWLIYTQIDQPAAIVVNPELGFMYWTDWGRQPKIECAWMDGQQR 4225

Human  4221 NILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRR-VIAKEAMNPYSLDIFEDQL 4284
            .:||.|||||||||:|||:|.:||||||.||::||:||.|||||: ||..:..||||||:||..|
 Frog  4226 QVLVSEDLGWPTGLTIDYINKNRIYWSDSKENIIESIKPDGTDRQTVITGDLGNPYSLDVFEGHL 4290

Human  4285 YWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQICSHLCLLRPGGY 4349
            ||.:||||||||::|||.|:|.|.|.||||||||||:|..|||.|||:.||.:||||||||||||
 Frog  4291 YWTTKEKGEVWKKDKFGTGQKVKVLTVNPWLTQVRIYHGHRYNHSVPSHCKDVCSHLCLLRPGGY 4355

Human  4350 SCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAF 4414
            :|:||||:.|:|||||:||||||.|..:||.|||||||.||:||:.||||||.|.|:|.||||.:
 Frog  4356 TCSCPQGTRFMEGSTTDCDAAIESPPTMPPACRCMHGGICYYDESGLPKCKCQSSYSGNYCEMGY 4420

Human  4415 SKGISPGTTAVAVLLTILLIVVIGALAIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTF 4479
            |||:.|||.|||||||::|:::||:|.|.|.|:|||||.|||:|||.||||.|||.|||||||||
 Frog  4421 SKGMPPGTAAVAVLLTVILVIIIGSLVIGGIFNYRRTGKLLPSLPKFPSLSGLVKSSENGNGVTF 4485

Human  4480 RSGADLNMDIGVSGFGPETAIDRSMAMSEDFVMEMGKQPIIFENPMYSARDSA--VKVVQPIQVT 4542
            |||.|::|||||||||.::||||.|.|:|.|.::.||:|.::|||||:..:.|  |.:.:|..||
 Frog  4486 RSGTDVSMDIGVSGFGADSAIDRVMQMNETFTVDTGKEPTVYENPMYTTSEGAAVVTISRPPDVT 4550

Human  4543 VSENVDNKNYGSP--INPSEIVPETNPTSPAADGTQ-VTKWNLFKRKSKQTTNFENPIYAQMENE 4604
               |::|...|:.  .||...| :|..:|.:.:.|| .:|||.||||.||:||||||:||:||.|
 Frog  4551 ---NINNNGQGADNFENPLYAV-DTPQSSGSLETTQPESKWNFFKRKIKQSTNFENPVYAEMEKE 4611

Human  4605 QKESVAATPPPSPSLPAKP-KPPSRRDPTP-TYSATEDTFKDTANLVKEDSEV 4655
            |:..  |...|||.....| |..::::..| :||.||||||||||||||||:|
 Frog  4612 QQNE--AEEDPSPFTSQSPEKSSNKKEQQPSSYSPTEDTFKDTANLVKEDSDV 4662

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP2NP_004516.2 LDLa 28..62 CDD:238060 20/33 (61%)
LDLa 108..142 CDD:238060 22/33 (67%)
LDLa 149..179 CDD:238060 20/29 (69%)
LDLa 183..217 CDD:238060 20/33 (61%)
LDLa 222..256 CDD:238060 22/33 (67%)
LDLa 266..300 CDD:238060 20/33 (61%)
YncE 394..579 CDD:442618 142/184 (77%)
LDL-receptor class B 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 436..478 34/41 (83%)
LDL-receptor class B 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 479..521 29/41 (71%)
LY 503..548 CDD:214531 34/44 (77%)
LDL-receptor class B 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 522..568 35/45 (78%)
LY 551..591 CDD:214531 30/39 (77%)
LDL-receptor class B 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 569..613 32/43 (74%)
FXa_inhibition 663..704 CDD:464251 28/40 (70%)
LDL-receptor class B 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 753..795 28/41 (68%)
LY 776..818 CDD:214531 33/41 (80%)
LDL-receptor class B 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 796..837 30/40 (75%)
LDL-receptor class B 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 838..881 32/42 (76%)
Ldl_recept_b 838..879 CDD:459654 30/40 (75%)
LY 864..904 CDD:214531 29/39 (74%)
LDL-receptor class B 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 882..925 32/42 (76%)
FXa_inhibition 981..1013 CDD:464251 24/31 (77%)
LDLa 1026..1060 CDD:238060 25/33 (76%)
LDLa 1067..1101 CDD:238060 24/33 (73%)
LDLa 1109..1143 CDD:238060 21/33 (64%)
LDLa 1149..1183 CDD:238060 26/33 (79%)
LDLa 1187..1222 CDD:238060 22/34 (65%)
LDLa 1230..1264 CDD:238060 25/33 (76%)
LDLa 1271..1305 CDD:238060 25/33 (76%)
LDLa 1311..1344 CDD:197566 22/32 (69%)
FXa_inhibition 1353..1388 CDD:464251 22/34 (65%)
EGF_CA 1390..1429 CDD:214542 24/38 (63%)
LY 1461..1500 CDD:214531 23/38 (61%)
LDL-receptor class B 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1478..1520 27/41 (66%)
LY 1501..1543 CDD:214531 29/41 (71%)
LDL-receptor class B 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1521..1563 34/41 (83%)
LY 1545..1589 CDD:214531 31/43 (72%)
LDL-receptor class B 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1566..1609 31/42 (74%)
LY 1591..1632 CDD:214531 27/40 (68%)
LDL-receptor class B 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1610..1654 25/43 (58%)
LDL-receptor class B 13. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1655..1695 29/39 (74%)
YvrE 1787..>1951 CDD:442613 111/163 (68%)
LDL-receptor class B 14. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1790..1832 29/41 (71%)
LDL-receptor class B 15. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1833..1882 33/48 (69%)
LDL-receptor class B 16. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1883..1930 27/46 (59%)
Ldl_recept_b 1883..1928 CDD:459654 26/44 (59%)
LY 1911..1953 CDD:214531 27/41 (66%)
LDL-receptor class B 17. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1931..1972 28/40 (70%)
LDL-receptor class B 18. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 1973..2013 25/39 (64%)
FXa_inhibition 2022..2058 CDD:464251 25/35 (71%)
YncE <2091..2252 CDD:442618 130/160 (81%)
LDL-receptor class B 19. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2107..2156 34/48 (71%)
LDL-receptor class B 20. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2157..2201 36/43 (84%)
LDL-receptor class B 21. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2202..2245 39/42 (93%)
LY 2227..2267 CDD:214531 32/39 (82%)
Vgb 2236..2544 CDD:443399 219/307 (71%)
LDL-receptor class B 22. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2246..2289 32/42 (76%)
LDL-receptor class B 23. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2431..2477 23/45 (51%)
LY 2459..2500 CDD:214531 28/40 (70%)
LDL-receptor class B 24. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2478..2518 30/39 (77%)
LY 2500..2542 CDD:214531 33/41 (80%)
LDL-receptor class B 25. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2519..2562 33/42 (79%)
LY 2545..2585 CDD:214531 28/39 (72%)
LDL-receptor class B 26. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2563..2604 23/40 (58%)
LY <2593..2625 CDD:214531 20/31 (65%)
LDL-receptor class B 27. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 2605..2646 22/40 (55%)
FXa_inhibition 2655..2692 CDD:464251 31/36 (86%)
LDLa 2700..2732 CDD:238060 22/31 (71%)
LDLa 2741..2775 CDD:238060 24/33 (73%)
LDLa 2784..2817 CDD:238060 22/32 (69%)
LDLa 2821..2854 CDD:197566 26/32 (81%)
Ldl_recept_a 2863..2895 CDD:395011 22/31 (71%)
LDLa 2905..2937 CDD:197566 23/31 (74%)
LDLa 2948..2988 CDD:238060 28/39 (72%)
LDLa 2993..3027 CDD:238060 22/33 (67%)
LDLa 3031..3063 CDD:197566 27/31 (87%)
LDLa 3075..3109 CDD:238060 21/33 (64%)
FXa_inhibition 3121..3150 CDD:464251 24/28 (86%)
vWFA <3147..3190 CDD:469594 33/42 (79%)
LY 3219..3260 CDD:214531 31/40 (78%)
LDL-receptor class B 28. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3239..3281 31/41 (76%)
LY 3262..3304 CDD:214531 25/41 (61%)
Ldl_recept_b 3282..3330 CDD:459654 25/47 (53%)
LDL-receptor class B 29. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3282..3324 23/41 (56%)
LDL-receptor class B 30. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3333..3376 30/42 (71%)
Ldl_recept_b 3333..3374 CDD:459654 28/40 (70%)
LY 3358..3399 CDD:214531 34/40 (85%)
LDL-receptor class B 31. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3377..3419 35/41 (85%)
LY <3408..3441 CDD:214531 30/32 (94%)
LDL-receptor class B 32. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 3420..3460 35/39 (90%)
FXa_inhibition 3469..>3498 CDD:464251 23/28 (82%)
LDLa 3512..3544 CDD:197566 26/31 (84%)
LDLa 3553..3584 CDD:197566 20/30 (67%)
LDLa 3594..3626 CDD:238060 24/31 (77%)
LDLa 3634..3666 CDD:197566 27/31 (87%)
LDLa 3682..3714 CDD:238060 24/31 (77%)
LDLa 3719..3754 CDD:238060 25/34 (74%)
LDLa 3759..3793 CDD:238060 27/33 (82%)
LDLa 3798..3832 CDD:238060 23/33 (70%)
LDLa 3885..3915 CDD:197566 21/29 (72%)
LDLa 3928..3962 CDD:238060 22/33 (67%)
EGF_CA 4007..4047 CDD:214542 23/39 (59%)
LY 4141..4176 CDD:214531 25/34 (74%)
LDL-receptor class B 33. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4154..4196 32/41 (78%)
LDL-receptor class B 34. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4197..4240 30/42 (71%)
Ldl_recept_b 4197..4238 CDD:459654 28/40 (70%)
LY 4222..4264 CDD:214531 30/41 (73%)
LDL-receptor class B 35. /evidence=ECO:0000255|PROSITE-ProRule:PRU00461 4242..4283 27/41 (66%)
FXa_inhibition 4338..>4356 CDD:464251 15/17 (88%)
SH3-binding. /evidence=ECO:0000255 4453..4462 6/8 (75%)
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4456..4461 3/4 (75%)
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250|UniProtKB:P98158 4459..4464 3/4 (75%)
Endocytosis signal. /evidence=ECO:0000255 4521..4526 3/4 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4550..4574 6/25 (24%)
Interaction with DAB2. /evidence=ECO:0000269|PubMed:10769163 4589..4602 9/12 (75%)
NPXY motif 4595..4598 2/2 (100%)
SH2-binding. /evidence=ECO:0000255 4598..4601 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 4601..4655 29/55 (53%)
SH3-binding. /evidence=ECO:0000255 4611..4622 4/10 (40%)
lrp2XP_012826499.2 LDLa 33..67 CDD:238060 20/33 (61%)
LDLa 111..145 CDD:238060 22/33 (67%)
LDLa 151..182 CDD:238060 20/30 (67%)
LDLa 186..220 CDD:238060 20/33 (61%)
LDLa 266..300 CDD:238060 20/33 (61%)
EGF_CA 348..385 CDD:214542 22/36 (61%)
YncE 389..577 CDD:442618 141/187 (75%)
LY 503..548 CDD:214531 34/44 (77%)
LY 551..591 CDD:214531 30/39 (77%)
FXa_inhibition 663..704 CDD:464251 28/40 (70%)
LY 776..818 CDD:214531 33/41 (80%)
Ldl_recept_b 838..879 CDD:459654 30/40 (75%)
LY 864..904 CDD:214531 29/39 (74%)
FXa_inhibition 981..1013 CDD:464251 24/31 (77%)
LDLa 1026..1060 CDD:238060 25/33 (76%)
LDLa 1067..1101 CDD:238060 24/33 (73%)
LDLa 1109..1143 CDD:238060 21/33 (64%)
LDLa 1149..1183 CDD:238060 26/33 (79%)
LDLa 1187..1222 CDD:238060 22/34 (65%)
LDLa 1230..1264 CDD:238060 25/33 (76%)
LDLa 1271..1305 CDD:238060 25/33 (76%)
LDLa 1311..1344 CDD:197566 22/32 (69%)
FXa_inhibition 1358..1393 CDD:464251 22/34 (65%)
EGF_CA 1395..1434 CDD:214542 24/38 (63%)
Ldl_recept_b 1483..1523 CDD:459654 25/39 (64%)
LY 1506..1548 CDD:214531 29/41 (71%)
LY 1550..1594 CDD:214531 31/43 (72%)
LY 1596..1637 CDD:214531 27/40 (68%)
FXa_inhibition 1714..1745 CDD:464251 21/30 (70%)
YncE 1754..1984 CDD:442618 155/229 (68%)
LY 1825..1857 CDD:214531 22/31 (71%)
Ldl_recept_b 1888..1932 CDD:459654 26/43 (60%)
LY 1917..1958 CDD:214531 27/40 (68%)
FXa_inhibition 2027..2063 CDD:464251 25/35 (71%)
Vgb 2090..>2298 CDD:443399 165/207 (80%)
LY 2187..2230 CDD:214531 37/42 (88%)
LY 2232..2272 CDD:214531 32/39 (82%)
FXa_inhibition 2351..2387 CDD:464251 26/35 (74%)
Vgb 2416..2647 CDD:443399 147/230 (64%)
LY 2463..2505 CDD:214531 28/41 (68%)
Ldl_recept_b 2524..2565 CDD:459654 31/40 (78%)
LY 2550..2590 CDD:214531 28/39 (72%)
FXa_inhibition 2660..2697 CDD:464251 31/36 (86%)
LDLa 2705..2737 CDD:238060 22/31 (71%)
LDLa 2746..2780 CDD:238060 24/33 (73%)
LDLa 2785..2822 CDD:238060 23/36 (64%)
LDLa 2826..2859 CDD:197566 26/32 (81%)
LDLa 2868..2900 CDD:197566 22/31 (71%)
LDLa 2910..2942 CDD:197566 23/31 (74%)
LDLa 2953..2993 CDD:238060 28/39 (72%)
LDLa 2998..3032 CDD:238060 22/33 (67%)
LDLa <3046..3068 CDD:197566 18/21 (86%)
LDLa 3080..3114 CDD:238060 21/33 (64%)
FXa_inhibition 3126..3155 CDD:464251 24/28 (86%)
vWFA <3152..3195 CDD:469594 33/42 (79%)
LY 3224..3265 CDD:214531 31/40 (78%)
LY 3267..3309 CDD:214531 25/41 (61%)
Ldl_recept_b 3338..3379 CDD:459654 28/40 (70%)
LY 3363..3404 CDD:214531 34/40 (85%)
LY 3405..3446 CDD:214531 37/40 (93%)
LDLa 3517..3549 CDD:238060 26/31 (84%)
LDLa 3558..3589 CDD:197566 20/30 (67%)
LDLa 3598..3630 CDD:197566 23/31 (74%)
LDLa 3639..3671 CDD:197566 27/31 (87%)
LDLa 3724..3759 CDD:238060 25/34 (74%)
LDLa 3764..3798 CDD:238060 27/33 (82%)
LDLa 3802..3834 CDD:197566 21/31 (68%)
LDLa 3847..3879 CDD:238060 26/31 (84%)
LDLa 3890..3920 CDD:197566 21/29 (72%)
LDLa 3933..3967 CDD:238060 22/33 (67%)
LY 4146..4181 CDD:214531 25/34 (74%)
Ldl_recept_b 4202..4243 CDD:459654 28/40 (70%)
LY 4226..4269 CDD:214531 30/42 (71%)
FXa_inhibition 4344..4371 CDD:464251 21/26 (81%)

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