DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pc and MPHOSPH8

DIOPT Version :9

Sequence 1:	NP_524199.1	Gene:	Pc / 40358	FlyBaseID:	FBgn0003042	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	XP_011533426.1	Gene:	MPHOSPH8 / 54737	HGNCID:	29810	Length:	879	Species:	Homo sapiens

Alignment Length:	494	Identity:	103/494 - (20%)
Similarity:	175/494 - (35%)	Gaps:	155/494 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GKLGRDN------------ATDDPVDLVYAAEKIIQKRVKKGVVEYRVKWKGWNQRYNTWEPEVN 62
            |.:|.||            :.:|..| |:..|||:..:.:.|.|.|:|:|||:....:|||||::
Human    32 GVVGEDNDAAARGAEAFGDSEEDGED-VFEVEKILDMKTEGGKVLYKVRWKGYTSDDDTWEPEIH 95

  Fly    63 ILD--------RRLI-------------------DIYEQTN--------KSSGTPSKRGIKKK-- 90
            :.|        |:.|                   ||:|..:        |...:|.|:  |||
Human    96 LEDCKEVLLEFRKKIAENKAKAVRKDIQRLSLNNDIFEANSDSDQQSETKEDTSPKKK--KKKLR 158

  Fly    91 ---EKEPD-----------------PEPESEEDEYTFTENDVDTHQATTSSATHDKESKKEKKHH 135
               ||.||                 |:.||..:...|   |:.|.:..:.:....|||||.||
Human   159 QREEKSPDDLKKKKAKAGKLKDKSKPDLESSLESLVF---DLRTKKRISEAKEELKESKKPKK-- 218

  Fly   136 HHHHHHHHIKSERNSGRRSESPLTHHHHHHHHESKRQR-IDHSSSSNSSFTHNSFVPEPDSNS-- 197
            ........:|..:....|.....|......:.::|::: ::....|.||..::|..||.||..
Human   219 DEVKETKELKKVKKGEIRDLKTKTREDPKENRKTKKEKFVESQVESESSVLNDSPFPEDDSEGLH 283

  Fly   198 -----------------------------------SSSEDQPLIG-----TKRKAEVLKESGKIG 222
                                               |:.||..:.|     |.||||..:|:.|:
Human   284 SDSREEKQNTKSARERAGQDMGLEHGFEKPLDSAMSAEEDTDVRGRRKKKTPRKAEDTRENRKL- 347

  Fly   223 VTIKTSPDGPTIKPQPTQQVTPSQQQPFQDQQQA----EKIASEAATQLKSEQQATPLATEAINT 283
                      ..|....::.|..::|..||:.::    ||:...:|...|..:    |:.|....
Human   348 ----------ENKNAFLEKKTVPKKQRNQDRSKSAAELEKLMPVSAQTPKGRR----LSGEERGL 398

  Fly   284 TPAESGAEEEEVANEEGNQQAPQ-----VPSENNNIPKPCNNL-AINQKQPLTPLSPRALPPRFW 342
            ...:|..|::|....|..::..:     ...:....||....| .|.....|..|:|.
Human   399 WSTDSAEEDKETKRNESKEKYQKRHDSDKEEKGRKEPKGLKTLKEIRNAFDLFKLTPE------- 456

  Fly   343 LPAKCNIS-NRVVITDVTVNLETVTIRECKTERGFFRER 380
              .|.::| |.....::.::.:|:...:.|..:...:||
Human   457 --EKNDVSENNRKREEIPLDFKTIDDHKTKENKQSLKER 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pc	NP_524199.1	CHROMO	25..77	CDD:214605	22/86 (26%)
MPHOSPH8	XP_011533426.1	CHROMO	57..109	CDD:237991	19/52 (37%)
		ANK	595..719	CDD:238125
		ANK repeat	600..631	CDD:293786
		Ank_2	606..695	CDD:289560
		ANK repeat	633..664	CDD:293786
		ANK repeat	666..695	CDD:293786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1628171at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920