DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7632 and Ephx2

DIOPT Version :9

Sequence 1:	NP_649302.1	Gene:	CG7632 / 40357	FlyBaseID:	FBgn0037071	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_075225.1	Gene:	Ephx2 / 65030	RGDID:	620732	Length:	554	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	73/388 - (18%)
Similarity:	140/388 - (36%)	Gaps:	108/388 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKVSRGLFLLKQLPNVRNSSSGPTKPFKILNKHFDEISIPVPW--GHISGKWYGPKHVRPIVGMH 63
            :|.:|.:.::..|  ||:::|...:..|:....|.|..:|||.  ..:|   :|...|:|.:.:|
  Rat   190 LKPARDMGMVTIL--VRDTASALRELEKVTGTQFPEAPLPVPCSPNDVS---HGYVTVKPGIRLH 249

  Fly    64 GWQDNAGTFDTLAPLLP-SHLSF--------------LSIDAPGHGLSSWLPPGTSYHSIDLV-- 111
            ..:..:|....|....| |..|:              |:||..|:|.|| .||....::::|:
  Rat   250 FVEMGSGPAICLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSS-SPPEIEEYAMELLCE 313

  Fly   112 -LITRRLMEEYNWDKISILAHSMSSINGFVFSALFPDKVDLFVGLDV-LKPP---------VRS- 164
             ::|  .:.:....:...:.|..:.:..:..:...|::|.....|:. |.||         :||
  Rat   314 EMVT--FLNKLGIPQAVFIGHDWAGVLVWNMALFHPERVRAVASLNTPLMPPNPEVSPMEVIRSI 376

  Fly   165 ----------ARGIVDSLTER--------------------IESALKLERRLKSGSEPPAYDWDQ 199
                      ..|:.::..|:                    :..|.::...|....|.|..
  Rat   377 PVFNYQLYFQEPGVAEAELEKNMSRTFKSFFRTSDDMGLLTVNKATEMGGILVGTPEDPKV---- 437

  Fly   200 LVTRLHEGSNKSVSIDACKYLLQRNCKPSTHEPHKYYFSRDNRLKSSLFYTLHQEVPMEMARRIK 264
                     :|..:.:..:|.:|:..|.....|..:|.:.:...|.|.         ..:.|:|.
  Rat   438 ---------SKITTEEEIEYYIQQFKKSGFRGPLNWYRNTERNWKWSC---------KALGRKIL 484

  Fly   265 CPHLFIKALQAPYYERKEYFDEVL-AELQKN-----PLFEYHEVEGT-HHVHLNEPEKVAPII 320
            .|.|.:.|.:          |.|| .|:.||     |..:...:|.. |...:.:|.:|..|:
  Rat   485 VPALMVTAEK----------DIVLRPEMSKNMENWIPFLKRGHIEDCGHWTQIEKPAEVNQIL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7632	NP_649302.1	MhpC	57..326	CDD:223669	58/330 (18%)
Ephx2	NP_075225.1	Phosphatase	1..224		8/35 (23%)
		HAD-SF-IA-v3	5..203	CDD:273662	3/14 (21%)
		Phosphate binding. /evidence=ECO:0000250\|UniProtKB:P34913	123..124
		HAD_like	<142..205	CDD:304363	4/16 (25%)
		Epoxide hydrolase	233..554		61/343 (18%)
		Abhydrolase	239..>379	CDD:304388	28/142 (20%)
		Abhydrolase_1	257..530	CDD:278959	52/307 (17%)
		Microbody targeting signal. /evidence=ECO:0000255	552..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335870
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840