DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7632 and Ephx2

DIOPT Version :9

Sequence 1:	NP_649302.1	Gene:	CG7632 / 40357	FlyBaseID:	FBgn0037071	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_031966.2	Gene:	Ephx2 / 13850	MGIID:	99500	Length:	554	Species:	Mus musculus

Alignment Length:	380	Identity:	71/380 - (18%)
Similarity:	145/380 - (38%)	Gaps:	92/380 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKVSRGLFLLKQLPNVRNSSSGPTKPFKILNKHFDEISIPVPW--GHISGKWYGPKHVRPIVGM- 62
            :|.:|.:.::..|  |.|::|...:..|:....|.|..:|||.  ..:|   :|...|:|.:.:
Mouse   190 LKPARDMGMVTIL--VHNTASALRELEKVTGTQFPEAPLPVPCNPNDVS---HGYVTVKPGIRLH 249

  Fly    63 -------------HGWQDNAGTFDTLAP-LLPSHLSFLSIDAPGHGLSSWLPPGTSYHSIDLV-- 111
                         ||:.::..::....| |..:....|:||..|:|.|| .||....::::|:
Mouse   250 FVEMGSGPALCLCHGFPESWFSWRYQIPALAQAGFRVLAIDMKGYGDSS-SPPEIEEYAMELLCK 313

  Fly   112 -LITRRLMEEYNWDKISILAHSMSSINGFVFSALFPDKVDLFVGLDV-LKPP---------VRS- 164
             ::|  .:::....:...:.|..:.:..:..:..:|::|.....|:. ..||         :||
Mouse   314 EMVT--FLDKLGIPQAVFIGHDWAGVMVWNMALFYPERVRAVASLNTPFMPPDPDVSPMKVIRSI 376

  Fly   165 ----------ARGIVDSLTERIESALKLERRLKS---GSEPPAY-------DWDQLVTRLHEGSN 209
                      ..|:.::..|:     .:.|..||   .|:...:       :...::....|..|
Mouse   377 PVFNYQLYFQEPGVAEAELEK-----NMSRTFKSFFRASDETGFIAVHKATEIGGILVNTPEDPN 436

  Fly   210 --KSVSIDACKYLLQRNCKPSTHEPHKYYFSRDNRLKSSLFYTLHQEVPMEMARRIKCPHLFIKA 272
              |..:.:..::.:|:..|.....|..:|.:.:...|.|.         ..:.|:|..|.|.:.|
Mouse   437 LSKITTEEEIEFYIQQFKKTGFRGPLNWYRNTERNWKWSC---------KGLGRKILVPALMVTA 492

  Fly   273 LQAPYYERKEYFDEVL-AELQKN-----PLFEYHEVEGT-HHVHLNEPEKVAPII 320
            .:          |.|| .|:.||     |..:...:|.. |...:.:|.:|..|:
Mouse   493 EK----------DIVLRPEMSKNMEKWIPFLKRGHIEDCGHWTQIEKPTEVNQIL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7632	NP_649302.1	MhpC	57..326	CDD:223669	56/322 (17%)
Ephx2	NP_031966.2	Phosphatase	1..224		8/35 (23%)
		HAD_sEH-N_like	3..214	CDD:319790	6/25 (24%)
		Phosphate binding. /evidence=ECO:0000250\|UniProtKB:P34913	123..124
		Epoxide hydrolase	233..554		59/335 (18%)
		Abhydrolase_1	257..530	CDD:395444	52/299 (17%)
		Microbody targeting signal. /evidence=ECO:0000255	552..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832207
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840