Protein Alignment CG11309 and MEST

DIOPT Version :10

• Sequence 1: NP_649301.1
• Gene: CG11309 / 40356
• FlyBaseID: FBgn0037070
• Length: 358
• Species: Drosophila melanogaster
• Sequence 2: NP_002393.2
• Gene: MEST / 4232
• HGNCID: 7028
• Length: 335
• Species: Homo sapiens
• Alignment Length: 381
• Identity: 62/381 - (16%)
• Similarity: 114/381 - (29%)
• Gaps: 131/381 - (34%)

  Fly    35 RANIWCSKKYFAEISITVPWGHISGKWYGPQNVQPILGLHGWQDNAGTF----------DRLMPL 89
            |...|..:.....:.:...:.||.     |..:.|  .||.|:.:...|          |.:..:
Human     9 RMREWWVQVGLLAVPLLAAYLHIP-----PPQLSP--ALHSWKSSGKFFTYKGLRIFYQDSVGVV 66

  Fly    90 LSPDVAFL--------------------------AIDLPGHGLSSRLPDGCYYNSVDNLYVIRLI 128
            .||::..|                          |:|..|.|.|.: |...:|:..:...::..:
Human    67 GSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDK-PRPHHYSIFEQASIVEAL 130

  Fly   129 MKQYKWE--KVSLVGHSMSSII---------------------CFVFAAVFPDKVDMIIGIDALK 170
            ::....:  :::|:.|....|:                     |.....:||:....::....||
Human   131 LRHLGLQNRRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLK 195

  Fly   171 PHQRPYPSVIRTME---------------TRLDEFLREDERNRSKNEPPSYTYDELIERVYIGTF 220
            ......|.:.|.|.               ||..|....|.....:|...:...|.|::  ||
Human   196 DGGVLSPILTRLMNFFVFSRGLTPVFGPYTRPSESELWDMWAGIRNNDGNLVIDSLLQ--YI--- 255

  Fly   221 HSVNKEHCKHLMARNIGKSEKYPDKYFFCRDRRLKFYNYAIGSQELCVEMANRITCPYLFIKAAQ 285
                                          ::|.||....:|:      :|: :|.|..||...
Human   256 ------------------------------NQRKKFRRRWVGA------LAS-VTIPIHFIYGP- 282

  Fly   286 SSYFEDKKYYDEVLDV---LLKKPNFEYLEVNGSHHVHMNDPEAIIAPVNNFIQRF 338
               .:....|.|.|::   .|.:.....|:.:.||:..:.||...:.....||..|
Human   283 ---LDPVNPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11309	NP_649301.1	alpha/beta hydrolases	69..324	CDD:473884	52/331 (16%)
MEST	NP_002393.2	MenH	45..334	CDD:440361	52/335 (16%)
		RVIALD	98..103		1/4 (25%)