DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and ZNF160

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	583	Identity:	125/583 - (21%)
Similarity:	190/583 - (32%)	Gaps:	157/583 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 GLATRCYICDDRCEPQTSLTDMCTTHTSTKFPNKLAQLVGEGFL---------VIVCGE-DYVCS 132
            |...:|..|.......::||.....|:..| |.|.:: .|:.|.         ||..|| .|.|.
Human   254 GKPYKCNECGKAFTQNSNLTSHRRIHSGEK-PYKCSE-CGKTFTVRSNLTIHQVIHTGEKPYKCH 316

  Fly   133 RCTNLVNYYDRLENDVERVKTNLISLLNKKYAINE--------------DMGQEGSPPLKMQ--- 180
            .|..:..:...|... .|:.|.     .|.|..||              .:...|..|.|..
Human   317 ECGKVFRHNSYLATH-RRIHTG-----EKPYKCNECGKAFRGHSNLTTHQLIHTGEKPFKCNECG 375

  Fly   181 KMVGGSANRSLEESPSADLLRPRKLLQG------NPVGQSKIAPGTTQSSVQGTQTVQRKATKIY 239
            |:.          :.::.|:...::..|      |..|::    .:.:||:...||: ....|.|
Human   376 KLF----------TQNSHLISHWRIHTGEKPYKCNECGKA----FSVRSSLAIHQTI-HTGEKPY 425

  Fly   240 KCTSC---------------------DYKTSDM-RLFNTHYETCKQQT-------FQCKTCRKIF 275
            ||..|                     .||.::. :.|:.|......|.       |:|..|.|:|
Human   426 KCNECGKVFRYNSYLGRHRRVHTGEKPYKCNECGKAFSMHSNLATHQVIHTGTKPFKCNECSKVF 490

  Fly   276 PHFGAMKQHMVRDHNTAMDNTCAMCHINFVNENSLRKHMETNHATNVLVTSTTTIPASAAPVAAA 340
            .....:..|. |.|.......|..|...|    |:|..:.|:.|          |.:...|....
Human   491 TQNSQLANHR-RIHTGEKPYKCNECGKAF----SVRSSLTTHQA----------IHSGEKPYKCI 540

  Fly   341 AAAAAAAANENL-------VGTSLYTCNHC--QFKSTDKVVFDEHMRKHAAGKPKPFKCRLCSQR 396
            ....:.....:|       .|...|.||.|  .|..|.::.  .|.|.|..  .||:||..|.:.
Human   541 ECGKSFTQKSHLRSHRGIHSGEKPYKCNECGKVFAQTSQLA--RHWRVHTG--EKPYKCNDCGRA 601

  Fly   397 FETREAATVHAKQHQ-TNFFKCGTCSMTFPKREMLVKHFEVH--QSPSASTVSPKQ-SVSQNLNT 457
            |..|.:.|.|...|. ...:||..|...|.....|..|..:|  :.|.......|. |:..||.|
Human   602 FSDRSSLTFHQAIHTGEKPYKCHECGKVFRHNSYLATHRRIHTGEKPYKCNECGKAFSMHSNLTT 666

  Fly   458 QKLLQETIDEALSDSLPASTAAVVATTESENNIRFFSCSICSLTFIQETYYNHHMETHRRDK--K 520
            .|                    |:.|.|..     :.|:.|...|.|.::..:|..||..:|  :
Human   667 HK--------------------VIHTGEKP-----YKCNQCGKVFTQNSHLANHQRTHTGEKPYR 706

  Fly   521 ATSAG-ATALNSAATALLSDEPGEATGKAGDESGE---QNAEADIESLFEKLHSDKNESGEAP 579
            ....| |.::.|:.|...:...|:...|. :|.|:   |||..   :...::|     :||.|
Human   707 CNECGKAFSVRSSLTTHQAIHTGKKPYKC-NECGKVFTQNAHL---ANHRRIH-----TGEKP 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	6/43 (14%)
		C2H2 Zn finger	268..289	CDD:275371	6/20 (30%)
		C2H2 Zn finger	297..318	CDD:275371	6/20 (30%)
		C2H2 Zn finger	360..380	CDD:275368	7/21 (33%)
		zf-H2C2_2	373..399	CDD:290200	9/25 (36%)
		zf-C2H2_8	375..443	CDD:292531	21/70 (30%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523	4/21 (19%)
		C2H2 Zn finger	259..279	CDD:275368	4/19 (21%)
		zf-H2C2_2	271..295	CDD:290200	7/25 (28%)
		C2H2 Zn finger	287..307	CDD:275368	3/20 (15%)
		zf-H2C2_2	299..324	CDD:290200	7/24 (29%)
		C2H2 Zn finger	315..335	CDD:275368	4/20 (20%)
		zf-H2C2_2	327..350	CDD:290200	7/28 (25%)
		C2H2 Zn finger	343..363	CDD:275368	2/19 (11%)
		zf-H2C2_2	355..380	CDD:290200	4/34 (12%)
		COG5048	367..810	CDD:227381	99/462 (21%)
		C2H2 Zn finger	371..391	CDD:275368	2/29 (7%)
		C2H2 Zn finger	399..419	CDD:275368	6/24 (25%)
		zf-H2C2_2	411..436	CDD:290200	8/25 (32%)
		C2H2 Zn finger	427..447	CDD:275368	2/19 (11%)
		zf-H2C2_2	439..463	CDD:290200	2/23 (9%)
		C2H2 Zn finger	455..475	CDD:275368	3/19 (16%)
		C2H2 Zn finger	483..503	CDD:275368	6/20 (30%)
		zf-H2C2_2	496..519	CDD:290200	6/27 (22%)
		C2H2 Zn finger	511..531	CDD:275368	7/33 (21%)
		zf-H2C2_2	523..548	CDD:290200	4/34 (12%)
		C2H2 Zn finger	539..559	CDD:275368	1/19 (5%)
		zf-H2C2_2	551..576	CDD:290200	7/24 (29%)
		C2H2 Zn finger	567..587	CDD:275368	7/21 (33%)
		C2H2 Zn finger	595..615	CDD:275368	6/19 (32%)
		zf-H2C2_2	607..632	CDD:290200	7/24 (29%)
		C2H2 Zn finger	623..643	CDD:275368	5/19 (26%)
		zf-H2C2_2	635..659	CDD:290200	5/23 (22%)
		C2H2 Zn finger	651..671	CDD:275368	7/39 (18%)
		zf-H2C2_2	663..688	CDD:290200	10/49 (20%)
		C2H2 Zn finger	679..699	CDD:275368	5/19 (26%)
		zf-H2C2_2	691..715	CDD:290200	6/23 (26%)
		C2H2 Zn finger	707..727	CDD:275368	4/19 (21%)
		zf-H2C2_2	719..744	CDD:290200	5/25 (20%)
		C2H2 Zn finger	735..755	CDD:275368	5/23 (22%)
		zf-H2C2_2	747..770	CDD:290200	4/22 (18%)
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142352
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930