DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and ZNF347

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_001166145.1	Gene:	ZNF347 / 84671	HGNCID:	16447	Length:	840	Species:	Homo sapiens

Alignment Length:	472	Identity:	98/472 - (20%)
Similarity:	144/472 - (30%)	Gaps:	124/472 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 RCYICDDRCEPQTSLTDMCTTHTSTKFPNKLAQLVGEGFLVIVCGEDYVCSRCTNLVNYYDRLEN 146
            :||.|......:::||.....||..|                    .|.|:.|
Human   291 KCYECGKAFRTRSNLTTHQVIHTGEK--------------------RYKCNEC------------ 323

  Fly   147 DVERVKTNLISLLNKKYAINEDMGQEGSPPLKMQKMVGGSANRSLEE-----SPSADLLRPRKLL 206
                         .|.::.|..:.|.       ||:..|.......|     :.::.|:|.|.:.
Human   324 -------------GKVFSRNSQLSQH-------QKIHTGEKPYKCNECGKVFTQNSHLVRHRGIH 368

  Fly   207 QG------NPVGQSKIAPGTTQSSV---QGTQTVQRKATKIYKCTSC-DYKTSDMRLFNTHYETC 261
            .|      |..|::..|    :||:   |.|.:    ..|.|||..| ...|.:..|.|......
Human   369 TGEKPYKCNECGKAFRA----RSSLAIHQATHS----GEKPYKCNECGKVFTQNSHLTNHWRIHT 425

  Fly   262 KQQTFQCKTCRKIFPHFGAMKQHMVRDHNTAMDNTCAMCHINFVNENSLRKHMETNHATNVLVTS 326
            .::.::|..|.|.|....::..|:| .|.......|..|...|...:.|.:|.
Human   426 GEKPYKCNECGKAFGVRSSLAIHLV-IHTGEKPYKCHECGKVFRRNSHLARHQ------------ 477

  Fly   327 TTTIPASAAPVAAAAAAAAAAANENL-------VGTSLYTCNHCQFKSTDKVVFDEHMRKHAAGK 384
              .|.....|........|..|:.||       .|...|.||.|....|.......|.|.|..
Human   478 --LIHTGEKPYKCNECGKAFRAHSNLTTHQVIHTGEKPYKCNECGKVFTQNSHLANHQRIHTG-- 538

  Fly   385 PKPFKCRLCSQRFETREAATVHAKQHQ-TNFFKCGTCSMTFPKREMLVKHFEVHQSPSA------ 442
            .||:.|..|.:.|....:.|.|...|. ...:||..|...|.:...|.:|..:|.....
Human   539 VKPYMCNECGKAFSVYSSLTTHQVIHTGEKPYKCNECGKVFTQNSHLARHRGIHTGEKPYKCNEC 603

  Fly   443 -------STVSPKQSVSQNLNTQKLLQETIDEALSDSLPASTAAVVATTESENNIRFFSCSICSL 500
                   |.:|..|.:.......|  .....:|.|:....:|..|:.|.|..     :.|:.|..
Human   604 GKVFRHNSYLSRHQRIHTGEKPYK--YNEYGKAFSEHSNLTTHQVIHTGEKP-----YKCNECGK 661

  Fly   501 TFIQETYYNHHMETHRR 517
            .|.|    |.|:..|||
Human   662 VFTQ----NSHLARHRR 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	5/22 (23%)
		C2H2 Zn finger	268..289	CDD:275371	6/20 (30%)
		C2H2 Zn finger	297..318	CDD:275371	5/20 (25%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..399	CDD:290200	8/25 (32%)
		zf-C2H2_8	375..443	CDD:292531	18/81 (22%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
ZNF347	NP_001166145.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	265..284	CDD:275368
		COG5048	273..728	CDD:227381	98/472 (21%)
		zf-H2C2_2	276..301	CDD:290200	3/9 (33%)
		C2H2 Zn finger	292..312	CDD:275368	5/19 (26%)
		zf-H2C2_2	304..329	CDD:290200	9/69 (13%)
		C2H2 Zn finger	320..340	CDD:275368	7/51 (14%)
		zf-H2C2_2	333..357	CDD:290200	5/30 (17%)
		C2H2 Zn finger	348..368	CDD:275368	4/19 (21%)
		zf-H2C2_2	360..383	CDD:290200	6/22 (27%)
		C2H2 Zn finger	376..396	CDD:275368	6/23 (26%)
		zf-H2C2_2	388..413	CDD:290200	8/28 (29%)
		C2H2 Zn finger	404..424	CDD:275368	5/19 (26%)
		zf-H2C2_2	416..439	CDD:290200	5/22 (23%)
		C2H2 Zn finger	432..452	CDD:275368	6/20 (30%)
		zf-H2C2_2	444..469	CDD:290200	6/25 (24%)
		zf-C2H2	458..480	CDD:278523	5/35 (14%)
		C2H2 Zn finger	460..480	CDD:275368	5/33 (15%)
		zf-H2C2_2	472..495	CDD:290200	4/36 (11%)
		C2H2 Zn finger	488..508	CDD:275368	4/19 (21%)
		zf-H2C2_2	500..525	CDD:290200	7/24 (29%)
		C2H2 Zn finger	516..536	CDD:275368	6/19 (32%)
		zf-H2C2_2	528..552	CDD:290200	7/25 (28%)
		C2H2 Zn finger	544..564	CDD:275368	5/19 (26%)
		zf-H2C2_2	556..581	CDD:290200	7/24 (29%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		zf-H2C2_2	584..609	CDD:290200	3/24 (13%)
		C2H2 Zn finger	600..620	CDD:275368	3/19 (16%)
		C2H2 Zn finger	628..648	CDD:275368	4/19 (21%)
		zf-H2C2_2	640..665	CDD:290200	7/29 (24%)
		C2H2 Zn finger	656..676	CDD:275368	9/23 (39%)
		zf-H2C2_2	668..693	CDD:290200	4/7 (57%)
		C2H2 Zn finger	684..704	CDD:275368
		zf-H2C2_2	697..720	CDD:290200
		C2H2 Zn finger	712..732	CDD:275368
		COG5048	723..>817	CDD:227381
		zf-H2C2_2	724..749	CDD:290200
		C2H2 Zn finger	740..760	CDD:275368
		zf-H2C2_2	752..777	CDD:290200
		C2H2 Zn finger	768..788	CDD:275368
		C2H2 Zn finger	795..813	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142385
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930