DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pzg and Rest

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_113976.2	Gene:	Rest / 83618	RGDID:	621069	Length:	1069	Species:	Rattus norvegicus

Alignment Length:	1103	Identity:	215/1103 - (19%)
Similarity:	350/1103 - (31%)	Gaps:	328/1103 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GASAGGASAVGGVAQQQAVNDAESGGVGIGGLATRCYICDDRCEPQTSLTDMCTTHTSTKFPNKL 112
            |.|:||.|...           .||.:|:                 ....||...|..:|.....
  Rat     7 GQSSGGGSLFN-----------NSGNMGM-----------------ALPNDMYDLHDLSKAELAA 43

  Fly   113 AQLV--------GEGFLVIVCGEDYVCSRCTNLVNYYDRLENDVERVKTNLISLLNKKYAINEDM 169
            .||:        ||     |.|     |.|..||.        .||....|:.:.:..::.:|..
  Rat    44 PQLIMLANVALTGE-----VNG-----SCCDYLVG--------EERQMAELMPVGDNHFSDSEGE 90

  Fly   170 GQEGSPPLKMQKMVGGSAN---RSLEESPSADLLRPRKLLQGNPVGQSKIAPGTTQSS------- 224
            |.|.|..||...  .|..|   ||||.|          :::..||.::..||....|:
  Rat    91 GLEESAELKGDP--SGLDNMELRSLELS----------VVEPQPVFEASAAPEVYSSNKDPAPEA 143

  Fly   225 -VQGTQTVQRKATKIYKCTSCDYKTSDMRLFNTHY-----------ETCKQQT------------ 265
             |...:....|| |.::|..|.|:......|..|.           |:.::|.
  Rat   144 PVAEDKCKNLKA-KPFRCKPCQYEAESEEQFVHHIRVHSAKKFFVEESAEKQAKARESGASPSEE 207

  Fly   266 -------FQCKTC---RKIFPHFGAMKQHMVRDHNTAMDNTCAMCHINFVNENSLRKHMETNHAT 320
                   .:|..|   ...:.|:.|..:|.:|..:......|.:|....|:|...|||:. ||..
  Rat   208 GEFSKGPIRCDRCGYNTNRYDHYTAHLKHHLRAGDNERVYKCIICTYTTVSEYHWRKHLR-NHFP 271

  Fly   321 NVLVTSTTTIPASAAPVAAAAAAAAAAANENLVGTSLYTCNHCQFKSTDKVVFDEHMRKHAAGKP 385
            .                                  .:|||:.|.:.|..|..:.:|:|.|..  .
  Rat   272 R----------------------------------KVYTCSKCNYFSDRKNNYVQHVRTHTG--E 300

  Fly   386 KPFKCRLCSQRFETREAATVHAKQHQ-TNFFKCGTCSMTFPKREMLVKHF-EVHQSPSASTVSPK 448
            :|:||.||......:...|.|.:.|. ...|||..|:.....:..:.:|. :||..|
  Rat   301 RPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCNYVASNQHEVTRHARQVHNGP-------- 357

  Fly   449 QSVSQNLNTQKLLQETIDEALSDSLPASTAAVVATTESENNIRFFSCSICSLTFIQETYYNHHME 513
                :.||......:|.|.          :......|...|.|.|:|.:|.....::....:|.:
  Rat   358 ----KPLNCPHCDYKTADR----------SNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFK 408

  Fly   514 THR-------------RDKKATSAGATALNSAATALLSDEPGEATGKAGDESGEQNAEADIESLF 565
            :..             :.||.....|.....||.|.......|.....|.::..:.:|..::.:.
  Rat   409 SKHPTCPSKTMDVSKVKLKKTKRREADLHRDAAAAATEQTDTEQAKTKGVDASARRSERPVKGVG 473

  Fly   566 EKLHSDKNESGEAPKPGSKGGEMVITSQ-----------EG--SGGITFNITIPQPDGDQSQKDS 617
            :.:..:|       ||.|....:.:|::           ||  :.|.|         |:.::|.|
  Rat   474 KDVPKEK-------KPCSNASVVQVTTRTRKSAVETKAAEGKHTDGQT---------GNNAEKSS 522

  Fly   618 ------------------PNTTAPVSVSIDMPNLDQAEDESQSQGSIDAKGESGEASSADSKSNA 664
                              |.|..||:      ...:.|.:.::.|.: .||...|...||.:.:|
  Rat   523 KAKKSKRKMDAEAHPSAEPVTEGPVT------KKKKTESKPKTSGEV-PKGSRVEDRKADKQQSA 580

  Fly   665 APVSMPSLDDDNEAAAAEAEASEETKTASKAGQEKAKAKAGESAKSKE-AAAAEEPQPSDEGDVV 728
                  |:....:..|.      :||||.| |.:.|....|.:..|.| |...|.|.|:....||
  Rat   581 ------SIKKGGKKTAL------KTKTAKK-GSKLAPKGVGHTEPSSEMAQGGESPVPALTQAVV 632

  Fly   729 AKREATDT----PTTESEANATTAEAGESGEGEVTASTGAEGEAGEAAGG--------------- 774
            ....:|.|    |...::......:..::|..:|......|....|.:..
  Rat   633 TPSGSTQTELSSPMDIAQTEPAQMDVSQTGPPQVQRPLPVEPAQLEPSPPQEPPQVEPPACVEPP 697

  Fly   775 ---------EHVAMELDEAMQ-AQVEGGQIKFIVNENGHL-----LQLDNHILTDAEGNQIIVQD 824
                     |...||....|: :|||         ...||     ::|....|...|..|..:..
  Rat   698 PPVEPPCPMEPAEMEPSPPMEPSQVE---------PPPHLEPPLPMELPQVELPPVEDCQKELPS 753

  Fly   825 PEQIQQLLQSVGVLQSGEGLEGETLQM-------MTDGSGQMVLVHGDNNEQQLIDASLLNSEGQ 882
            .|..|..:...|..|.| .::.|.|.:       :|..|..    ..|..:::|...|.:..:.|
  Rat   754 VEHAQTKVAQTGPTQVG-AVQEEPLSVSEPPQVKLTRRSSP----RKDRAKEKLSVLSEMARQEQ 813

  Fly   883 LIIQQGQDGEEGAHVI--SEDGTRIPVSVSYTEDGQPIVQVQQQVLEAAQQAASASGGADDKEAA 945
            ::|:.|......:.::  |:....:|...|      |:.:...:..|..:.....|.|..:|.:.
  Rat   814 VLIEVGLVPVRDSQLLKASKSAPDLPAPPS------PLPKGHLRREETPKDQEMFSDGEGNKVSP 872

  Fly   946 ADSAG-EEVQVSEASSGTASTTVVATSTASSTGGPSGGSFFA-----------LEEFTETKTD 996
            .:..| ||...|.|.......:..|.|:..|:..|.|.:..:           :|..||.|||
  Rat   873 LEKGGTEEAGESRAELAAPMESTSALSSEQSSNAPDGETLHSECQADSTAVCEMEVDTEQKTD 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	6/32 (19%)
		C2H2 Zn finger	268..289	CDD:275371	6/23 (26%)
		C2H2 Zn finger	297..318	CDD:275371	7/20 (35%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..399	CDD:290200	8/25 (32%)
		zf-C2H2_8	375..443	CDD:292531	19/69 (28%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	417..437	CDD:275368	3/20 (15%)
Rest	NP_113976.2	C2H2 Zn finger	249..269	CDD:275368	7/20 (35%)
		COG5048	<270..413	CDD:227381	36/200 (18%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		zf-H2C2_2	289..314	CDD:404364	8/26 (31%)
		zf-H2C2_5	303..327	CDD:404746	7/23 (30%)
		C2H2 Zn finger	305..325	CDD:275368	5/19 (26%)
		zf-H2C2_2	317..342	CDD:404364	7/24 (29%)
		C2H2 Zn finger	333..351	CDD:275368	3/17 (18%)
		C2H2 Zn finger	390..406	CDD:275368	2/15 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	59	1.000	Inparanoid score	I5314
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050