DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and ZNF665

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_001340387.1	Gene:	ZNF665 / 79788	HGNCID:	25885	Length:	706	Species:	Homo sapiens

Alignment Length:	558	Identity:	118/558 - (21%)
Similarity:	181/558 - (32%)	Gaps:	129/558 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 YICDDRCEPQTSLTDMCTTHTSTKFPNKLAQL--VGEGFL---------VIVCGE-DYVCSRCTN 136
            |.||: |....|.....|:|.......|..|.  .|:.|.         ||..|| .|.|:.|..
Human   206 YKCDE-CGKVFSQNSRLTSHKRIHTGEKPYQCNKCGKAFTVRSNLTIHQVIHTGEKPYKCNECGK 269

  Fly   137 LVNYYDRLENDVERVKTNLISLLNKKYAINE--------------DMGQEGSPPLKMQKMVGGSA 187
            :.:....|... :|:.|.     .|.|..||              .:...|..|.|. |..|...
Human   270 VFSQPSNLAGH-QRIHTG-----EKPYKCNECGKAFRAHSKLTTHQVIHTGEKPYKC-KECGKCF 327

  Fly   188 NRSLEESPSADLLRPRKLLQGNPVGQSKIAPGTTQSSVQGTQTVQRKATKIYKCTSC-------- 244
            .::...:....:....|..:.|..|::    .:.:||:...||: ....|.|||..|
Human   328 TQNSHLASHRRIHTGEKPYKCNECGKA----FSVRSSLTTHQTI-HTGEKPYKCNECGKVFRHNS 387

  Fly   245 -------------DYKTSDM-RLFNTHYETCKQQ-------TFQCKTCRKIFPHFGAMKQHMVRD 288
                         .||.::. :.|:.|....|.|       .|:|..|.|:|..:..:..|. |.
Human   388 YLAKHRRIHTGEKPYKCNECGKAFSMHSNLTKHQIIHTGEKPFKCNECVKVFTQYSHLANHR-RI 451

  Fly   289 HNTAMDNTCAMCHINFVNENSLRKHMETNHATNVLVTSTTTIPASAAPVAAAAAAAAAAANENLV 353
            |.......|..|...|    |:|..:.|:.|          |.....|............|.:|.
Human   452 HTGEKPYRCDECGKAF----SVRSSLTTHQA----------IHTGEKPYKCNDCGKVFTQNSHLA 502

  Fly   354 -------GTSLYTCNHC--QFKSTDKVVFDEHMRKHAAGKPKPFKCRLCSQRFETREAATVHAKQ 409
                   |...|.|:.|  .|..|.::.  .|.|.|..  .||:||..|.:.|....:.|:|...
Human   503 SHRGIHSGEKPYKCDECGKAFSQTSQLA--RHWRVHTG--EKPYKCNECGKAFSVHSSLTIHQTI 563

  Fly   410 HQ-TNFFKCGTCSMTFPKREMLVKHFEVH--QSPSASTVSPKQ-SVSQNLNTQKLLQETIDEALS 470
            |. ...:||..|...|.....|..|..:|  :.|.......|. ||..||.|.:
Human   564 HTGQKPYKCNDCGKVFRHNSYLAIHQRIHTGEKPYKCNECGKAFSVHSNLATHQ----------- 617

  Fly   471 DSLPASTAAVVATTESENNIRFFSCSICSLTFIQETYYNHHMETHRRDK--KATSAG-ATALNSA 532
                     |:.|.|..     :.|:.|...|.|.::..:|...|..:|  :....| |.::.|.
Human   618 ---------VIHTGEKP-----YKCNECGKVFTQNSHLANHRRIHTGEKPYRCNECGKAFSVRST 668

  Fly   533 ATALLSDEPGEATGKAGDESGEQNAEADIESLFEKLHS 570
            .|..::...|:...|. ::.|:...:....:...::||
Human   669 LTTHMAVHTGDKPYKC-NQCGKVFTQNSNLAKHRRIHS 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	6/43 (14%)
		C2H2 Zn finger	268..289	CDD:275371	6/20 (30%)
		C2H2 Zn finger	297..318	CDD:275371	6/20 (30%)
		C2H2 Zn finger	360..380	CDD:275368	6/21 (29%)
		zf-H2C2_2	373..399	CDD:290200	9/25 (36%)
		zf-C2H2_8	375..443	CDD:292531	20/70 (29%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
ZNF665	NP_001340387.1	KRAB	37..76	CDD:307490
		COG5048	192..580	CDD:227381	88/405 (22%)
		C2H2 Zn finger	208..228	CDD:275368	6/20 (30%)
		C2H2 Zn finger	236..256	CDD:275368	3/19 (16%)
		C2H2 Zn finger	264..284	CDD:275368	4/20 (20%)
		C2H2 Zn finger	292..312	CDD:275368	2/19 (11%)
		C2H2 Zn finger	320..340	CDD:275368	2/20 (10%)
		C2H2 Zn finger	348..368	CDD:275368	6/24 (25%)
		C2H2 Zn finger	376..396	CDD:275368	2/19 (11%)
		C2H2 Zn finger	404..424	CDD:275368	4/19 (21%)
		C2H2 Zn finger	432..452	CDD:275368	6/20 (30%)
		C2H2 Zn finger	460..480	CDD:275368	7/33 (21%)
		C2H2 Zn finger	488..508	CDD:275368	2/19 (11%)
		C2H2 Zn finger	516..536	CDD:275368	6/21 (29%)
		C2H2 Zn finger	544..564	CDD:275368	5/19 (26%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		zf-H2C2_2	584..608	CDD:316026	5/23 (22%)
		C2H2 Zn finger	600..620	CDD:275368	7/39 (18%)
		zf-H2C2_2	612..637	CDD:316026	9/49 (18%)
		C2H2 Zn finger	628..648	CDD:275368	5/19 (26%)
		zf-H2C2_2	640..664	CDD:316026	5/23 (22%)
		C2H2 Zn finger	656..676	CDD:275368	4/19 (21%)
		zf-H2C2_2	669..693	CDD:316026	4/24 (17%)
		C2H2 Zn finger	684..704	CDD:275368	1/20 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142353
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930