DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and ZNF142

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_001353219.1	Gene:	ZNF142 / 7701	HGNCID:	12927	Length:	1887	Species:	Homo sapiens

Alignment Length:	844	Identity:	154/844 - (18%)
Similarity:	257/844 - (30%)	Gaps:	285/844 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GGASAGGASAVGGVAQQQAV----------NDAESGGVGIGGLATRCYICDDRCEPQTSLTDMCT 101
            |..:.|..|||.|:..|:.:          ..::..|..:.|..|    .::....:...:|  |
Human   273 GAGTQGELSAVQGLPSQELLPAPKLPPGEREPSQEAGTPLPGQET----AEEENVEKEEKSD--T 331

  Fly   102 THTSTKFPNKLAQLVGEG---------------FLVIVCGEDYVCSRC----TNLVNYY------ 141
            ...|.|..:|     |:|               |...:|.|   |.||    |:||.:.
Human   332 QKDSQKAVDK-----GQGAQRLEGDVVSGTESLFKTHMCPE---CKRCFKKRTHLVEHLHLHFPD 388

  Fly   142 --------DRLENDVERVKTNLISLLNKK--------------YAINEDMGQ------------E 172
                    .:......::||:|:..|.:|              .|:|..|..            .
Human   389 PSLQCPNCQKFFTSKSKLKTHLLRELGEKAHHCPLCHYSAVERNALNRHMASMHEDISNFYSDTY 453

  Fly   173 GSPPLKMQKMVGGSANRSLEESPSADLLRPRKLLQGNPVGQSKIAPGTTQ-----SSVQGTQTVQ 232
            ..|..:.:..:..:....|:...:|....|.. |:....|.|..||....     ....|.:.|:
Human   454 ACPVCREEFRLSQALKEHLKSHTAAAAAEPLP-LRCFQEGCSYAAPDRKAFIKHLKETHGVRAVE 517

  Fly   233 -------------------RKATKIYKCTSCDYKTSDMRLFNTHYET------------CKQQTF 266
                               .|:...:.|..||:..|:..||..|.:.            |...||
Human   518 CRHHSCPMLFATAEAMEAHHKSHYAFHCPHCDFACSNKHLFRKHKKQGHPGSEELRCTFCPFATF 582

  Fly   267 -------------------QCKTCRKIFPHFGAMKQHMVRDHNTAMDNTCAMCHINFVNENSLRK 312
                               ||..|.....|...:.:||:. |.....:.|.:|.....:.:.|.|
Human   583 NPVAYQDHVGKMHAHEKIHQCPECNFATAHKRVLIRHMLL-HTGEKPHKCELCDFTCRDVSYLSK 646

  Fly   313 HMETNHATNVLVTSTTTIPASAAPVAAAAAAAAAAANENLVGTSLYTCNHCQFKSTDKVVFDEHM 377
            ||.|:.                                   .|..|.|..|.:.:..|.....||
Human   647 HMLTHS-----------------------------------NTKDYMCTECGYVTKWKHYLRVHM 676

  Fly   378 RKHAAGKPKPFKCRLCSQRFETREAATVHAKQHQTNFFKCGTCSMTFPKREMLVKHFEVHQSPSA 442
            ||||.  ...::|..||.|....:..:.|..:||.....|..|:....::..|.||......|
Human   677 RKHAG--DLRYQCNQCSYRCHRADQLSSHKLRHQGKSLMCEVCAFACKRKYELQKHMASQHHP-- 737

  Fly   443 STVSP-------------KQSVSQNLNTQKLLQETIDEALSDSLPASTAAVVATTESENNIRFFS 494
            .|.:|             ||:|..:.|.:                            ...:|.|.
Human   738 GTPAPLYPCHYCSYQSRHKQAVLSHENCK----------------------------HTRLREFH 774

  Fly   495 CSICSL-TFIQETYYNHHMETH--------------RRDKKATSAGAT-ALNSAATALLS---DE 540
            |::|.. ||...|...|..:.|              .::.:....|.| ..:|..:..||   :.
Human   775 CALCDYRTFSNTTLLFHKRKAHGYVPGDQAWQLRYASQEPEGAMQGPTPPPDSEPSNQLSARPEG 839

  Fly   541 PGEATGKAGDESGEQNAEADIESLFEKLHSDKNESGEAPKPGSKGGEMVITSQEGSGGITFNI-- 603
            ||...|...|.|.:|    .:..:.|::::.:.|..|||..|..||.......| .|..|.::
Human   840 PGHEPGTVVDPSLDQ----ALPEMSEEVNTGRQEGSEAPHGGDLGGSPSPAEVE-EGSCTLHLEA 899

  Fly   604 ------TIPQPDGDQSQKDSPNTTAPVSV----SIDMPNLDQAEDESQSQGSIDAKGESGEASSA 658
                  ::.:|..::..:.:|....|:.:    .::.|.|          .|.:..|.| :.|:.
Human   900 LGVELESVTEPPLEEVTETAPMEFRPLGLEGPDGLEGPEL----------SSFEGIGTS-DLSAE 953

  Fly   659 DSKSNAAPVSMPSLDDDN----------------EAAAAEAEASEETKTASKA--GQEKAKAKA 704
            ::.....|||.||.:..:                .|..|......|:::..||  .|:|.:|:|
Human   954 ENPLLEKPVSEPSTNPPSLEEAPNNWVGTFKTTPPAETAPLPPLPESESLLKALRRQDKEQAEA 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	8/33 (24%)
		C2H2 Zn finger	268..289	CDD:275371	5/20 (25%)
		C2H2 Zn finger	297..318	CDD:275371	7/20 (35%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..399	CDD:290200	10/25 (40%)
		zf-C2H2_8	375..443	CDD:292531	19/67 (28%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
ZNF142	NP_001353219.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2H2 Zn finger	365..385	CDD:275368	8/22 (36%)
		C2H2 Zn finger	393..413	CDD:275368	3/19 (16%)
		C2H2 Zn finger	421..438	CDD:275368	2/16 (13%)
		C2H2 Zn finger	455..475	CDD:275368	2/19 (11%)
		C2H2 Zn finger	545..566	CDD:275368	7/20 (35%)
		C2H2 Zn finger	574..595	CDD:275368	3/20 (15%)
		zf-H2C2_5	601..625	CDD:404746	7/24 (29%)
		C2H2 Zn finger	603..623	CDD:275368	5/20 (25%)
		C2H2 Zn finger	631..651	CDD:275368	6/19 (32%)
		C2H2 Zn finger	659..679	CDD:275368	6/19 (32%)
		C2H2 Zn finger	687..707	CDD:275368	5/19 (26%)
		C2H2 Zn finger	714..731	CDD:275368	4/16 (25%)
		PHA03247	928..>1219	CDD:223021	20/101 (20%)
		C2H2 Zn finger	1306..1353	CDD:275368
		C2H2 Zn finger	1373..1394	CDD:275368
		C2H2 Zn finger	1402..1422	CDD:275368
		C2H2 Zn finger	1430..1451	CDD:275368
		C2H2 Zn finger	1626..1646	CDD:275368
		C2H2 Zn finger	1654..1674	CDD:275368
		C2H2 Zn finger	1682..1702	CDD:275368
		C2H2 Zn finger	1710..1730	CDD:275368
		zf-H2C2_2	1723..1747	CDD:404364
		C2H2 Zn finger	1738..1759	CDD:275368
		C2H2 Zn finger	1767..1787	CDD:275368
		C2H2 Zn finger	1795..1815	CDD:275368
		C2H2 Zn finger	1823..1843	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910