DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and ZNF28

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_008900.3	Gene:	ZNF28 / 7576	HGNCID:	13073	Length:	718	Species:	Homo sapiens

Alignment Length:	587	Identity:	113/587 - (19%)
Similarity:	200/587 - (34%)	Gaps:	141/587 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 QQAVNDAESGGVGIGGLATRCYICDDRCEPQTSLTDMC---TTHTSTKFPNKLAQLVGEGFLVIV 124
            ::::|:|.|       ::|...||   |.|:|.:::..   :.|:|.....:...:..:.|..|.
Human   165 EKSINNASS-------VSTSQRIC---CRPKTHISNKYGNNSLHSSLLTQKRNVHMREKSFQCIE 219

  Fly   125 CGEDYVCS------RCTNL------VNYYDRLENDVERVKTNLISLLNKK-YAINEDMGQEGSPP 176
            .|:.:.||      :.|:|      .:.|.::.|....:..:..|.:::| |..||
Human   220 SGKSFNCSSLLKKHQITHLEEKQCKCDVYGKVFNQKRYLACHRRSHIDEKPYKCNE--------- 275

  Fly   177 LKMQKMVGGSANRSLEES-PSADLLRPRKLLQGNPVGQSKIAPGTTQSSVQGTQTVQRKATKIYK 240
              ..|:.|.:.:..|.:: .:||  :|.:..:.:.|...|        |...|..:.....|.||
Human   276 --CGKIFGHNTSLFLHKALHTAD--KPYECEECDKVFSRK--------SHLETHKIIYTGGKPYK 328

  Fly   241 CTSCDYKTSDMRLFNTHYETCK-------QQTFQCKTCRKIFPHFGAMKQHMVRDHNTAMDNTCA 298
            |..||      :.|..:....|       ::.::|..|.|:|.....:.:|. |.|.......|.
Human   329 CKVCD------KAFTCNSYLAKHTIIHTGEKPYKCNECGKVFNRLSTLARHR-RLHTGEKPYECE 386

  Fly   299 MCHINFVNENSLRKHMETNHATNVLVTSTTTIPASAAPVAAAAAAAAAAANENL-------VGTS 356
            .|...|..::.|.:|..              |.....|........|.|.|..|       .|..
Human   387 ECEKVFSRKSHLERHKR--------------IHTGEKPYKCKVCDKAFAYNSYLAKHSIIHTGEK 437

  Fly   357 LYTCNHCQFKSTDKVVFDEHMRKHAAGKP--------------------------KPFKCRLCSQ 395
            .|.||.|......:.....|.|.|.|.||                          ||:||::|.:
Human   438 PYKCNECGKVFNQQSTLARHHRLHTAEKPYKCEECDKVFRCKSHLERHRRIHTGEKPYKCKVCDK 502

  Fly   396 RFETREAATVHAKQHQ-TNFFKCGTCSMTFPKREMLVKHFEVHQSPSASTVSPKQSVSQNLNTQK 459
            .|.:....|.|.:.|. ...:.|..|...|..:..|..|.::|     :...|.:.
Human   503 AFRSDSCLTEHQRVHTGEKPYMCNECGKVFSTKANLACHHKLH-----TAEKPYKC--------- 553

  Fly   460 LLQETIDEALSDSLPASTAAVVATTESENNIRFFSCSICSLTFIQETYYNHHMETHRRDK--KAT 522
               |..::..|..........:.|.|..     :.|.:|...|.::::...|...|..:|  |..
Human   554 ---EECEKVFSRKSHMERHRRIHTGEKP-----YKCKVCDKAFRRDSHLAQHQRVHTGEKPYKCN 610

  Fly   523 SAGATALNSAATALLSD-EPGEATGKAGDESGEQNAEADIESLFEKLHSDKNESGEAPKPGSKGG 586
            ..|.|...:::..:... ..||...|. :|.|:..::........:||     |||.|...::.|
Human   611 ECGKTFRQTSSLIIHRRLHTGEKPYKC-NECGKTFSQMSSLVYHHRLH-----SGEKPYKCNECG 669

  Fly   587 EM 588
            ::
Human   670 KV 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	5/28 (18%)
		C2H2 Zn finger	268..289	CDD:275371	6/20 (30%)
		C2H2 Zn finger	297..318	CDD:275371	5/20 (25%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		zf-H2C2_2	373..399	CDD:290200	12/51 (24%)
		zf-C2H2_8	375..443	CDD:292531	21/94 (22%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
ZNF28	NP_008900.3	KRAB	8..>48	CDD:214630
		KRAB	8..47	CDD:279668
		COG5048	<143..373	CDD:227381	47/244 (19%)
		C2H2 Zn finger	217..237	CDD:275368	4/19 (21%)
		C2H2 Zn finger	245..265	CDD:275368	2/19 (11%)
		COG5048	267..655	CDD:227381	85/452 (19%)
		C2H2 Zn finger	273..293	CDD:275368	5/30 (17%)
		C2H2 Zn finger	301..321	CDD:275368	4/27 (15%)
		C2H2 Zn finger	329..349	CDD:275368	5/25 (20%)
		zf-H2C2_2	341..366	CDD:290200	5/24 (21%)
		C2H2 Zn finger	357..377	CDD:275368	6/20 (30%)
		zf-H2C2_2	370..394	CDD:290200	6/24 (25%)
		C2H2 Zn finger	385..405	CDD:275368	5/33 (15%)
		zf-H2C2_2	397..422	CDD:290200	5/38 (13%)
		C2H2 Zn finger	413..433	CDD:275368	4/19 (21%)
		zf-H2C2_2	425..450	CDD:290200	6/24 (25%)
		C2H2 Zn finger	441..461	CDD:275368	5/19 (26%)
		C2H2 Zn finger	469..489	CDD:275368	0/19 (0%)
		zf-H2C2_2	481..506	CDD:290200	6/24 (25%)
		C2H2 Zn finger	497..517	CDD:275368	5/19 (26%)
		zf-H2C2_2	510..534	CDD:290200	6/23 (26%)
		C2H2 Zn finger	525..545	CDD:275368	5/19 (26%)
		C2H2 Zn finger	553..573	CDD:275368	2/31 (6%)
		zf-H2C2_2	565..590	CDD:290200	5/29 (17%)
		C2H2 Zn finger	581..601	CDD:275368	4/19 (21%)
		zf-H2C2_2	593..618	CDD:290200	6/24 (25%)
		C2H2 Zn finger	609..629	CDD:275368	2/19 (11%)
		zf-H2C2_2	621..646	CDD:290200	5/25 (20%)
		C2H2 Zn finger	637..657	CDD:275368	2/20 (10%)
		C2H2 Zn finger	665..685	CDD:275368	1/7 (14%)
		zf-H2C2_2	677..702	CDD:290200
		C2H2 Zn finger	693..713	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910