DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and ZNF335

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_071378.1	Gene:	ZNF335 / 63925	HGNCID:	15807	Length:	1342	Species:	Homo sapiens

Alignment Length:	900	Identity:	181/900 - (20%)
Similarity:	272/900 - (30%)	Gaps:	289/900 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 TKIYKCTSCD----YKTSDMRLFNTHYE--------TCKQQTFQCKTCRKIFPHFGAMKQHMVRD 288
            :|.|||..|.    |:...:|....|..        |.|..:|.|..|.:::|....:.||| :.
Human   520 SKPYKCDECSYTSVYRKDVIRHAAVHSRDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHM-KT 583

  Fly   289 HNTAMDNTCAMCHINFVNENSLRKHMETNHATNVLVTSTTTIPASAAPVAAAAAAAAAAANENLV 353
            |:|...:.|..|..:|....:.:.|:.|:                          ..|.||..
Human   584 HSTEKPHMCDKCGKSFKKRYTFKMHLLTH--------------------------IQAVANRR-- 620

  Fly   354 GTSLYTCNHCQFKSTDKVVFDEHMRKHAAGKPKPFKCRLCSQRFETREAATVHAKQHQTNF--FK 416
                :.|..|:|...||.....|...|.:  .|||||..|..|....:....|.....|..  |.
Human   621 ----FKCEFCEFVCEDKKALLNHQLSHVS--DKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFA 679

  Fly   417 CGTCSMTFPKREMLVKHFEVHQSPSASTVSPKQSVSQNLNTQKLLQETIDEALSDSLPASTAAVV 481
            |..|..:...::.|..|.....:.|......:..               :|..|...|
Human   680 CEYCHFSTRHKKNLRLHVRCRHASSFEEWGRRHP---------------EEPPSRRRP------- 722

  Fly   482 ATTESENNIRFFSCSICSLTFIQETYYNHHMETHRRDKKATSAG-------ATALNS--AATALL 537
                      ||     ||..|:|....|   :.......:|.|       ||...|  |.:.|.
Human   723 ----------FF-----SLQQIEELKQQH---SAAPGPPPSSPGPPEIPPEATTFQSSEAPSLLC 769

  Fly   538 SDEPGEAT---GKAGDESGEQNAEADIESLFEKLHSDKNESGEAPKPGSKGGEMVITSQEGSGGI 599
            ||..|.||   .:..:||.....:..::.|.       |.|.:....|:.....|:.|::...|:
Human   770 SDTLGGATIIYQQGAEESTAMATQTALDLLL-------NMSAQRELGGTALQVAVVKSEDVEAGL 827

  Fly   600 TFNITIPQPDGDQSQ-----KDSPNTTAPVSVSIDMPNLDQAEDESQSQGSIDAKGESGEASSAD 659
            ......|.|:|...|     ...|...|.....:..|:|.|.   :.:.|.....|.|...:...
Human   828 ASPGGQPSPEGATPQVVTLHVAEPGGGAAAESQLGPPDLPQI---TLAPGPFGGTGYSVITAPPM 889

  Fly   660 SKSNAAPVSMPSLDDDNEAAAAEAEASEETKTASKAGQEKAKAKAGE-------------SAKSK 711
            .:..:||.:..|    .|.|...|:|...:.|..:||.....|..|.             |..|.
Human   890 EEGTSAPGTPYS----EEPAGEAAQAVVVSDTLKEAGTHYIMATDGTQLHHIELTADGSISFPSP 950

  Fly   712 EAAAA-----------------EEPQPSDEGDVVAKREATDTPTTESEA----------NATTAE 749
            :|.|:                 |.|.|:....|...:.:..:|...|:|          :|.||.
Human   951 DALASGAKWPLLQCGGLPRDGPEPPSPAKTHCVGDSQSSASSPPATSKALGLAVPPSPPSAATAA 1015

  Fly   750 A--------GESGEGEVTASTGAEGEAGEAA-------------------GGEHVAMELDEAMQA 787
            :        .|:..|.....:.....||..|                   ..:|.::...:..|.
Human  1016 SKKFSCKICAEAFPGRAEMESHKRAHAGPGAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCSQC 1080

  Fly   788 QVEGGQIKFI---------------------VNENGHL--------------------------- 804
            .......|.:                     .|.||||
Human  1081 SFASKNKKDLRRHMLTHTKEKPFACHLCGQRFNRNGHLKFHIQRLHSPDGRKSGTPTARAPTQTP 1145

  Fly   805 -----LQLDNHILT-------DAEGNQIIVQDPEQIQQLLQSVGVLQSGEGL-----EGETLQMM 852
                 |..|:..|.       .:.|    |..||::||.|....::.:.|..     |...:|.:
Human  1146 TQTIILNSDDETLATLHTALQSSHG----VLGPERLQQALSQEHIIVAQEQTVTNQEEAAYIQEI 1206

  Fly   853 TDGSGQMV--LVHGDNNEQQLIDAS----------LLNSEGQLI-IQQGQ----DGEEGAHVISE 900
            |...||.|  ||..||..|.:|...          ::..||..| :|:||    ..|:||..:.|
Human  1207 TTADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPEGHHIQVQEGQITHIQYEQGAPFLQE 1271

  Fly   901 DGTR-IPVSVSYTEDGQPIVQVQQQVLEAAQQAASASGGADDKEAAADSAGEEVQ 954
            ...: :|||     .||.:  |.|..||||..:|..        |.||:|..:.|
Human  1272 SQIQYVPVS-----PGQQL--VTQAQLEAAAHSAVT--------AVADAAMAQAQ 1311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	6/33 (18%)
		C2H2 Zn finger	268..289	CDD:275371	6/20 (30%)
		C2H2 Zn finger	297..318	CDD:275371	5/20 (25%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..399	CDD:290200	9/25 (36%)
		zf-C2H2_8	375..443	CDD:292531	17/69 (25%)
		C2H2 Zn finger	390..410	CDD:275368	4/19 (21%)
		C2H2 Zn finger	417..437	CDD:275368	4/19 (21%)
ZNF335	NP_071378.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..442
		C2H2 Zn finger	467..487	CDD:275368
		C2H2 Zn finger	497..517	CDD:275368
		zf-H2C2_2	509..534	CDD:290200	5/13 (38%)
		C2H2 Zn finger	529..545	CDD:275370	2/15 (13%)
		C2H2 Zn finger	564..584	CDD:275368	6/20 (30%)
		zf-H2C2_2	577..600	CDD:290200	7/23 (30%)
		zf-C2H2	590..612	CDD:278523	4/21 (19%)
		C2H2 Zn finger	592..612	CDD:275368	4/19 (21%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)
		C2H2 Zn finger	651..672	CDD:275368	4/20 (20%)
		C2H2 Zn finger	680..699	CDD:275368	4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..763		6/33 (18%)
		PRK04654	<795..911	CDD:135173	25/129 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1013		8/48 (17%)
		C2H2 Zn finger	1021..1041	CDD:275368	2/19 (11%)
		Involved in the interaction with CCAR2. /evidence=ECO:0000269\|PubMed:19131338	1041..1342		60/289 (21%)
		C2H2 Zn finger	1049..1069	CDD:275368	0/19 (0%)
		zf-H2C2_5	1075..1097	CDD:290620	2/21 (10%)
		C2H2 Zn finger	1077..1097	CDD:275368	2/19 (11%)
		zf-H2C2_2	1089..1114	CDD:290200	0/24 (0%)
		C2H2 Zn finger	1105..1126	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100