DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and ZNF462

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	XP_006717272.1	Gene:	ZNF462 / 58499	HGNCID:	21684	Length:	2567	Species:	Homo sapiens

Alignment Length:	819	Identity:	153/819 - (18%)
Similarity:	264/819 - (32%)	Gaps:	259/819 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 VGGVAQQQAVNDAESGGVGIGGLATRCYICDDRCEPQTSLTDMCTTHTSTKFPNKLAQLVGEGFL 121
            |.|.||:            |..|..||..|   .:...|..::...|.:......|.:    .|:
Human  1834 VEGEAQE------------IEWLPFRCIKC---FKLSFSTAELLCMHYTDHHSRDLKR----DFI 1879

  Fly   122 VIVCG-----EDYVCSRC----------TNLVNYY-DRLENDVERVKTNLISLLNKKYAIN--ED 168
            ::..|     ..|.|..|          |:.:|.: :..:...:|.:.....|..:|||..  .|
Human  1880 ILGNGPRLQNSTYQCKHCDSKLQSTAELTSHLNIHNEEFQKRAKRQERRKQLLSKQKYADGAFAD 1944

  Fly   169 MGQEGS-------PPLKMQKMVGGSANRSLEESPS------------------------------ 196
            ..||..       |.:|.:|:||......:|..|:
Human  1945 FKQERPFGHLEEVPKIKERKVVGYKCKFCVEVHPTLRAICNHLRKHVQYGNVPAVSAAVKQEADD 2009

  Fly   197 -----ADLLRPRKLLQGNPVG-------------QSKIAPG--------TTQSSVQGTQTVQRKA 235
                 .|.|...|...|..||             :.:..||        ....|:||.::.:|..
Human  2010 PAHLFLDGLEAAKDASGALVGRVDGEHCLLDGMLEDETRPGGYHCSQCDRVLMSMQGLRSHERSH 2074

  Fly   236 TKI--------YKCTSCDYKTSDMRLFNTHYET--CKQQTFQCKTCRKIFPHFGAMKQHMVRDHN 290
            ..:        |.|..|.:.::.....:.|.:|  ...:.|:||.|.....:...:|.|:::.|.
Human  2075 LALAMFTREDKYSCQYCSFVSAFRHNLDRHMQTHHGHHKPFRCKLCSFKSSYNSRLKTHILKAHA 2139

  Fly   291 TAMDNTCAMCH-----INFVNENSLRKH-------------METNHATNVLVTSTTTIPA----- 332
            ......|:.|.     |:.:.|:||:.|             :.::|:.:   :|....||
Human  2140 GEHAYKCSWCSFSTMTISQLKEHSLKVHGKALTLPRPRIVSLLSSHSHH---SSQKATPAEEVED 2201

  Fly   333 --------------------SAA------PVAAAAAAAAAAANENLVGTSLYTCNHCQFKSTDKV 371
                                |||      .|:....:.|||..|......|: |..|:|.|....
Human  2202 SNDSSYSEPPDVQQQLNHYQSAALARNNSRVSPVPLSGAAAGTEQKTEAVLH-CEFCEFSSGYIQ 2265

  Fly   372 VFDEHMRKHAAGKPKPFKCRLCSQRFETREAATVHAK-------QHQTNFFKCGTCSMTFPKREM 429
            ....|.|....|| |.|||:.||.....:.|.|:|.:       :......:|..|......:..
Human  2266 SIRRHYRDKHGGK-KLFKCKDCSFYTGFKSAFTMHVEAGHSAVPEEGPKDLRCPLCLYHTKYKRN 2329

  Fly   430 LVKHFEVHQSPSASTVSPKQSVSQNLNTQKLLQETI------------DEALSDSLPASTAAVVA 482
            ::.|..:|:.   ..|.|.:.....|:  |.||..:            ||:|...:
Human  2330 MIDHIVLHRE---ERVVPIEVCRSKLS--KYLQGVVFRCDKCTFTCSSDESLQQHI--------- 2380

  Fly   483 TTESENNIRFFSCSICSLTFIQETYYNHHMETHRRDKKATSAG---ATALNSAATALLSDEPGEA 544
              |..|.::.:.|.:|    ..||.:...:::|.||:...|..   ...:|......:.::...:
Human  2381 --EKHNELKPYKCQLC----YYETKHTEELDSHLRDEHKVSRNFELVGRVNLDQLEQMKEKMESS 2439

  Fly   545 TGKAGDESGEQNAEADIESLFE------KLHSDK----NESGEAPKPGSKGGEMVITSQEGSGGI 599
            :....|:..|.|::|:...|..      .|:::|    ...|.|...||:....|:..     |:
Human  2440 SSDDEDKEEEMNSKAEDRELMRFSDHGAALNTEKRFPCEFCGRAFSQGSEWERHVLRH-----GM 2499

  Fly   600 TFNITIPQPDGDQSQKDSPNTTAPVSVSIDMPNLDQAEDESQSQGSIDAKGESGEASSADSKSNA 664
            ..|      |..|..::..:....:..|:.||::::.||:              ||...|.
Human  2500 ALN------DTKQVSREEIHPKEIMENSVKMPSIEEKEDD--------------EAIGIDF---- 2540

  Fly   665 APVSMPSLDDDNEAAAAEAEASEETKTASKAGQEKAKAK 703
                  ||.::..|..        ..||.|:..|.|:||
Human  2541 ------SLKNETVAIC--------VVTADKSLLENAEAK 2565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	4/23 (17%)
		C2H2 Zn finger	268..289	CDD:275371	5/20 (25%)
		C2H2 Zn finger	297..318	CDD:275371	7/38 (18%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..399	CDD:290200	10/25 (40%)
		zf-C2H2_8	375..443	CDD:292531	17/74 (23%)
		C2H2 Zn finger	390..410	CDD:275368	6/26 (23%)
		C2H2 Zn finger	417..437	CDD:275368	3/19 (16%)
ZNF462	XP_006717272.1	C2H2 Zn finger	2054..2074	CDD:275368	4/19 (21%)
		C2H2 Zn finger	2088..2108	CDD:275368	3/19 (16%)
		C2H2 Zn finger	2117..2138	CDD:275368	5/20 (25%)
		zf-H2C2_5	2144..2169	CDD:316431	7/24 (29%)
		C2H2 Zn finger	2146..2167	CDD:275368	6/20 (30%)
		C2H2 Zn finger	2317..2337	CDD:275368	3/19 (16%)
		C2H2 Zn finger	2363..2383	CDD:275368	4/30 (13%)
		C2H2 Zn finger	2391..2412	CDD:275368	7/24 (29%)
		C2H2 Zn finger	2477..2497	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010