DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pzg and zfp91

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	XP_021326898.1	Gene:	zfp91 / 555616	ZFINID:	ZDB-GENE-090313-11	Length:	792	Species:	Danio rerio

Alignment Length:	782	Identity:	130/782 - (16%)
Similarity:	227/782 - (29%)	Gaps:	277/782 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 RCEPQTSLTDMCT----THTSTKFPNKLAQLVGEGFLVIVCGEDYVCSRCTNLVNYYDRLEN--- 146
            |.:..:::||..:    ..:|::.|:       ||...|...||         |.:.|.|.:
Zfish   232 RQDKHSTMTDSSSDSDEAESSSQIPH-------EGEETISSDED---------VPFRDDLNDQSY 280

  Fly   147 ---DVERVKTNLISLLNKKYAINEDMGQEGSPPLKMQKMVGGSANRSLEESPSADLLR----PRK 204
               |..:.|....:.|.:|    :|.......|.:.:..:......:.||...|::..    |||
Zfish   281 DPKDFSKSKRRPHTRLKEK----KDKPTVQETPTEQETEIKTEGGETTEEQTRAEVEEGAEPPRK 341

  Fly   205 LLQGNPVGQSKIAPGTTQSSVQGTQTVQRKATKIYKC--TSCDYKTSDMRLFNTH--YETCKQQT 265
            ..:.....:|...|          :..::...:..:|  ..|....:..|....|  |:...::.
Zfish   342 RGRRRKDDKSPRLP----------KRRKKPPVQYVRCEMEGCGTVLAHPRYLQHHIKYQHLMKKK 396

  Fly   266 FQC--KTCRKIFPHFGAMKQHMVRDHNTAMDNTCAMCHINFVNENSLRKHMETNHATNVLVTSTT 328
            :.|  .||.::|.....:.:| .:.|....|..|..|...|.:.::|..|...:
Zfish   397 YVCPHPTCGRLFRLQKQLLRH-AKHHTDQRDYICEFCARAFKSSHNLAVHRMIH----------- 449

  Fly   329 TIPASAAPVAAAAAAAAAAANENLVGTSLYTCNHCQFKSTDKVVFDEHMRKHAAGKPKPFKCRLC 393
                                    .|.....|..|.|....|...:.||:||.|.....|.|.:|
Zfish   450 ------------------------TGEKPLQCEICGFTCRQKASLNWHMKKHDADATYQFSCSIC 490

  Fly   394 SQRFETREAATVH-AKQHQTNFFKCGTCSMTFPKREMLVKHFEVHQSPSASTVSPKQSVSQNLNT 457
            .::||.:::...| ||.|.                |:|:
Zfish   491 GKKFEKKDSVVAHKAKSHP----------------EVLI-------------------------- 513

  Fly   458 QKLLQETIDEALSDSLPASTAAVVATTESENNIRFFSCSICSLTFIQETYYNHHMETHRRDKKAT 522
                        :::|.|:..|::.|.             ..:|.:.||              .|
Zfish   514 ------------AEALAANAGALITTP-------------AGVTTLLET--------------NT 539

  Fly   523 SAGATALNSAATALLSDEPGEATGKAGDESGEQNAEADIESLFEKLHSDKN---ESGEAPKPGSK 584
            .:|.|...      :|:..|.:|..||.       .|.:..:...:..|:|   .|.:.|.
Zfish   540 GSGQTEQG------VSETRGSSTVPAGQ-------VAPVTHVGPVMVVDQNHPLHSMQVPV---- 587

  Fly   585 GGEMVITSQEGSGGITFNITIPQPDGDQSQKDSPNTTAPVSVSIDMPNLDQAEDESQ------SQ 643
              .:.::|.|.:     |..:.|......|......::|||        .|.:.:.|      |.
Zfish   588 --TLALSSTEEN-----NTPLQQTSSHSLQMPLQFVSSPVS--------QQQQQQIQQHPLHPSV 637

  Fly   644 GSIDAKGESGEASSADSKSNAAPV---SMPSLDDDNEAAAAEAEASEETKTASKAGQEKAKAKAG 705
            .||..:....:.....|.|..:|:   :..:|........:.|:......|.|...|...:..:.
Zfish   638 TSISQQATLVQQLPVQSYSQQSPIVHMAFRALPQQQLPMVSVAQQMPLQTTQSHQNQALPRLSSH 702

  Fly   706 ESAKSKEAAAAEEPQ--------------PSDEGDVVAKREATDTPTTESEANATTAEA---GES 753
            ..|.:....:...|:              ||.....     :|.:..|.||......||   .|:
Zfish   703 HQAPNTPLLSQNLPKALSDCRSGLGFRSDPSSSSST-----STQSSITPSETRQVIWEADGTNEN 762

  Fly   754 GEGEVTASTGAEGEAGEAAGGEHVAMELDEAMQAQVEGGQIKFIVNENGHLLQLDNHILTDAEGN 818
            |.|:..|  |.|||                                         ...:||:.||
Zfish   763 GAGDWVA--GGEGE-----------------------------------------EQSITDSSGN 784

  Fly   819 QI 820
            ||
Zfish   785 QI 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	5/25 (20%)
		C2H2 Zn finger	268..289	CDD:275371	5/22 (23%)
		C2H2 Zn finger	297..318	CDD:275371	5/20 (25%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..399	CDD:290200	9/25 (36%)
		zf-C2H2_8	375..443	CDD:292531	16/68 (24%)
		C2H2 Zn finger	390..410	CDD:275368	7/20 (35%)
		C2H2 Zn finger	417..437	CDD:275368	2/19 (11%)
zfp91	XP_021326898.1	zf-C2H2_8	368..445	CDD:318181	16/77 (21%)
		C2H2 Zn finger	402..421	CDD:275368	4/19 (21%)
		C2H2 Zn finger	429..449	CDD:275368	5/19 (26%)
		zf-C2H2	456..477	CDD:306579	6/20 (30%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		C2H2 Zn finger	487..503	CDD:275368	4/15 (27%)
		Amelogenin	<633..>716	CDD:330537	12/82 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100