DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and ZNF107

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	634	Identity:	123/634 - (19%)
Similarity:	199/634 - (31%)	Gaps:	173/634 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 RCYICDDRCEPQTSLTDMCTTHTSTKFPNKLAQLVGEGF---------LVIVCGED-YVCSRCTN 136
            :|..|....:..:.||.....||..| |.|..: .|:.|         .::..||: |.|..|..
Human   302 KCEECGKAFKQASHLTIHKIIHTGEK-PYKYEE-CGKVFSQSSHLTTQKILHTGENLYKCKECGK 364

  Fly   137 LVNYYDRLENDVERVKTNLISLLNKKYAINEDMGQEGSPPLKMQKMVGGSANRSLEESPSADLLR 201
            ..|.:..|.|. :|:                   ..|..|.|. |..|.:.|
Human   365 AFNLFSNLTNH-KRI-------------------HAGEKPYKC-KECGRAFN------------- 395

  Fly   202 PRKLLQGNPVGQSKIAPGTTQSSVQGTQTVQRKATKIYKCTSCDYKTSDMRLFNTHYE-TCKQQT 265
                :..|...|.||..|                .|:.||..||...:.......|.: ..:::.
Human   396 ----ISSNLNKQEKIHTG----------------GKLNKCEECDKAFNRSLKLTAHKKILMEEKP 440

  Fly   266 FQCKTCRKIFPHFGAMKQHMVRDHNTAMDNTCAMCHINFVNENSLRKHMET-------------- 316
            ::|:.|.|:|..|..:.:|.: .|.......|..|...|...::|.:|.:.
Human   441 YKCEECGKVFNQFSTLTRHKI-IHTGEKPYKCKECGKAFNQSSNLTEHKKIHTAEKSYKCEECGK 504

  Fly   317 --NHATNVLVTSTTTIPASAAPVAAAAAAAAAAANENL-------VGTSLYTCNHCQFKSTDKVV 372
              |..:|::  :...|.:...|........|...:..|       .|...|.|..|....:....
Human   505 AFNQHSNLI--NHRKIYSGEKPYKCEECGKAFNRSSTLTRHKKIHTGEKPYKCEECDRAFSQSSN 567

  Fly   373 FDEHMRKHAAGKPKPFKCRLCSQRFETREAATVHAKQHQ-TNFFKCGTCSMTFPKREMLVKHFEV 436
            ..||.:.|..  .||:||..|.:.|......|.|.:.|. ...:||..|...|.:...|.:|..|
Human   568 LTEHKKIHTG--EKPYKCEECGKAFNRFSTLTKHKRIHTGEKPYKCEECGKAFNQSYQLTRHKIV 630

  Fly   437 HQSPSASTVSP-----KQS--------------------------VSQNLNTQKLLQ-------- 462
            |.....:....     |||                          .|.||.|||::.
Human   631 HTKEKLNKCEEFGKAFKQSSHRTIHKIIHTGEKPYKCEEHGKVFNQSSNLTTQKIIHTGENLYKF 695

  Fly   463 ETIDEALSDSLPASTAAVVATTESENNI--------RF---------------FSCSICSLTFIQ 504
            |...:|.:.....:...::.|.|..:..        ||               :.|:.|...|..
Human   696 EEHGKAFNLFSNITNHKIIYTGEKPHKCEECGKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFNC 760

  Fly   505 ETYYNHHMETHRRDK--KATSAG-ATALNSAATALLSDEPGEATGKAGDESGEQNAEADIESLFE 566
            .:..|.|...|..:|  |....| |..|:|..||......||...|. :|.|:...::...:..:
Human   761 SSTLNRHKIIHTGEKPYKCKECGKAFNLSSTLTAHKKIHTGEKPYKC-EECGKAFNQSSNLTTHK 824

  Fly   567 KLHSDK-----NESGEAPKPGSKGG--EMVITSQE----GSGGITFNIT 604
            |:|:.:     .|.|::....|...  :::.|.::    |..|..||::
Human   825 KIHTSEKPYKCEECGKSFNQFSSLNIHKIIHTGEKPYKCGDYGRAFNLS 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	4/22 (18%)
		C2H2 Zn finger	268..289	CDD:275371	6/20 (30%)
		C2H2 Zn finger	297..318	CDD:275371	5/36 (14%)
		C2H2 Zn finger	360..380	CDD:275368	4/19 (21%)
		zf-H2C2_2	373..399	CDD:290200	9/25 (36%)
		zf-C2H2_8	375..443	CDD:292531	20/68 (29%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368
		C2H2 Zn finger	219..239	CDD:275368
		COG5048	243..621	CDD:227381	75/379 (20%)
		C2H2 Zn finger	247..267	CDD:275368
		C2H2 Zn finger	275..295	CDD:275368
		C2H2 Zn finger	303..323	CDD:275368	4/19 (21%)
		C2H2 Zn finger	331..351	CDD:275368	2/20 (10%)
		C2H2 Zn finger	359..379	CDD:275368	6/39 (15%)
		C2H2 Zn finger	387..407	CDD:275368	6/37 (16%)
		C2H2 Zn finger	415..435	CDD:275368	4/19 (21%)
		C2H2 Zn finger	443..463	CDD:275368	6/20 (30%)
		C2H2 Zn finger	471..491	CDD:275368	5/19 (26%)
		C2H2 Zn finger	499..519	CDD:275368	2/21 (10%)
		C2H2 Zn finger	527..547	CDD:275368	2/19 (11%)
		COG5048	551..>863	CDD:227381	63/314 (20%)
		C2H2 Zn finger	555..575	CDD:275368	4/19 (21%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		C2H2 Zn finger	611..631	CDD:275368	5/19 (26%)
		C2H2 Zn finger	639..659	CDD:275368	3/19 (16%)
		C2H2 Zn finger	699..715	CDD:275368	1/15 (7%)
		C2H2 Zn finger	723..743	CDD:275368	2/19 (11%)
		C2H2 Zn finger	751..771	CDD:275368	5/19 (26%)
		C2H2 Zn finger	779..799	CDD:275368	6/19 (32%)
		C2H2 Zn finger	807..827	CDD:275368	3/20 (15%)
		C2H2 Zn finger	835..855	CDD:275368	3/19 (16%)
		C2H2 Zn finger	863..883	CDD:275368	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142199
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930