DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and CG6791

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_650090.1	Gene:	CG6791 / 41391	FlyBaseID:	FBgn0037918	Length:	1243	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	138/745 - (18%)
Similarity:	219/745 - (29%)	Gaps:	236/745 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LNPATYRKFNNLLSSGAVTVTGPSQPRILKSTRMVVPGGGGGGGASAGGASAVGGVAQQQAVNDA 69
            |...::|:.::|         |....||.....::.|.....|             .|:|.|::.
  Fly   289 LREKSFRENDDL---------GEESDRIEVRNELLEPDADESG-------------TQEQTVSEE 331

  Fly    70 ES-GGVGIGGLATRC-----YICDDRCEPQTSLTDMCTTHTS----TKFPNKLAQLVGEGFLVIV 124
            .| ...|..|.|..|     |:|.| |.     || |.||..    .:|.:......|..|..:
  Fly   332 VSKKKAGTRGAAELCEDYIHYMCPD-CG-----TD-CDTHAQWSQHIEFVHDYVSRRGLNFRSV- 388

  Fly   125 CGEDYVCSRCTNLVNYYDRLENDVERVKTNLISLLN-----------KKYA-------------- 164
             .....|..|..:|.     .|.::.::.:..|.|:           |.|.
  Fly   389 -DMQMQCLECKKIVT-----PNTIKSLRAHKFSHLSQPEWLRCKLCYKGYTDHQEIIRHLLQQHH 447

  Fly   165 ----INEDMGQEGSPPLKMQKMVGGSANRSLEESPSADLLRPRKLLQGNPVGQSKIAPGTTQSSV 225
                ::||..:|           .|.|..::|:....|        .||  |:...||....|..
  Fly   448 MDTLMSEDAEEE-----------DGDAPSAIEDECDGD--------NGN--GEGNGAPLDEDSPY 491

  Fly   226 QGTQTVQRKATKI-----------YKCTSCDYKTSDMRLFNTH--------------YETCKQQT 265
              .:...|:..:|           |.|..|..:..:.:.:.||              :|...::.
  Fly   492 --FEDAPRRGGRISSDDIFEPHIDYLCPQCGKEFIEKKHWRTHVVMAHSMNDLSKLNFEMINERQ 554

  Fly   266 FQCKTCRKIFPH-FGAM--KQHMVRDHNTAMDNTCAMCHINFVNENSLRKHMETNHATNVLVTST 327
            .:|..|.||..: :|..  :||.:..........|..||.::.:...|.||:.|:|........:
  Fly   555 LKCTECDKIITNAYGIQNAQQHRITHLPFKAYARCRKCHKSYTDRKGLVKHLATHHRVGWPRKLS 619

  Fly   328 TTIPAS-AAPVAAAAAAAAAAANENLVGTSLYTCNHCQFKSTDKVVFDEHMRKH------AAGKP 385
            ...||. ..|...........|||..  ..:|..:..|....:...|.|.|:..      |...|
  Fly   620 GGCPAPILTPAKQPRKQIVTVANETY--EIIYLDDVDQGGMEEDNDFGEQMQAEEDEYPIAPPPP 682

  Fly   386 KP--------------FKCRLCSQRFETREAATVHAKQ--------------------------H 410
            .|              :||..|...|.|:.|..||..:                          .
  Fly   683 SPPPPPQPTTQGNHQRYKCVHCGTLFATQAAVRVHISEKRCRKTVVRRRRQPVMSSADPSVPTVE 747

  Fly   411 QTNFFKCGTCSMTFPKREMLVKHF-EVHQSPSASTVSPKQSVSQNLNTQKL------LQETIDEA 468
            |...|.|.:|...:..:....:|. |||....          .|.||.::|      ..:..|..
  Fly   748 QNYIFLCPSCGFEYKTQFEWRRHINEVHNFDK----------RQYLNMRQLDKYRYQCTQCKDIV 802

  Fly   469 LSDSLPASTAAVVATTESENNIR------FFSCSICSLTFIQETYYNH--HMETHRRDKKATSAG 525
            .:..|...         .:::.|      :..|.||.      |.|||  ::..|.|.:.
  Fly   803 CNSKLKGL---------QDHHFRHLPYRLYLKCLICG------TCYNHKPNIAAHLRARH----- 847

  Fly   526 ATALNSAATALLSDEPGEATGKAGDESGEQNAEADIESLFEKLHSDKNESGEAPKPGSKGGEMVI 590
              ::....|..:..:|.:..|:..|.|.|.          .||.|.......||.|.|...
  Fly   848 --SIFDRETPTMITKPKQVLGRYKDNSREN----------PKLPSPPPAPALAPAPPSPPA---- 896

  Fly   591 TSQEGSGGITFNITIPQPDGDQSQKDSPNT 620
            .|...:...:.....|||.|..::....||
  Fly   897 CSSSAAASASSRSLKPQPGGLPARPAGLNT 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	5/35 (14%)
		C2H2 Zn finger	268..289	CDD:275371	7/23 (30%)
		C2H2 Zn finger	297..318	CDD:275371	7/20 (35%)
		C2H2 Zn finger	360..380	CDD:275368	4/19 (21%)
		zf-H2C2_2	373..399	CDD:290200	10/45 (22%)
		zf-C2H2_8	375..443	CDD:292531	21/114 (18%)
		C2H2 Zn finger	390..410	CDD:275368	7/45 (16%)
		C2H2 Zn finger	417..437	CDD:275368	4/20 (20%)
CG6791	NP_650090.1	C2H2 Zn finger	167..188	CDD:275368
		C2H2 Zn finger	208..230	CDD:275368
		C2H2 Zn finger	235..256	CDD:275368
		C2H2 Zn finger	516..532	CDD:275368	2/15 (13%)
		C2H2 Zn finger	557..580	CDD:275368	7/22 (32%)
		C2H2 Zn finger	589..609	CDD:275368	6/19 (32%)
		COG5236	<939..>1096	CDD:227561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455502
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930