DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pzg and CG2199

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster

Alignment Length:	758	Identity:	143/758 - (18%)
Similarity:	245/758 - (32%)	Gaps:	261/758 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 LTDMCTTHTSTKFPNKLAQLVGEGFLVIVCGEDYVC-SRCTNLVNYYDRLENDVERVKTNLISLL 159
            :||:..|.|....|:.|.        :.:|   :|| |...:.....:::...|:||:
  Fly    43 ITDVLETITHRSIPSSLP--------IKIC---FVCTSTFMSSAALIEKVRETVDRVQ------- 89

  Fly   160 NKKYAINEDMGQEGSPPLKMQKMVGGSANRSLEESPSADLLRPRK---LLQGNPVGQSKIAPGTT 221
                          ..|.|..| |......|.:||....:..|:|   |.|     :||......
  Fly    90 --------------EQPAKKTK-VAEIEEPSTQESDKKAVKVPKKNTTLRQ-----RSKSIAAFP 134

  Fly   222 QSSVQGTQT------VQRKATKIYKCTSCDYKTSDMRLFNTHYETCKQQT--FQCKTCRKIFPHF 278
            .|.|.|..|      :.....|:.|..    |....|||..:.....:.|  .:..:.:|.|
  Fly   135 PSFVNGANTNTEIEIISASPKKLDKTP----KKQISRLFEDNLNDSVKLTPAKEVSSTKKAF--- 192

  Fly   279 GAMKQHMVRDHNTAMDNTCAMCHINFVNENSLRKHMETNHATNVLVTSTTTIPASAAPVAAAAAA 343
                                   :|......       |.|..||..|.....:...|:.
  Fly   193 -----------------------LNLFGNGG-------NDAIEVLTESEEEEDSDKGPIT----- 222

  Fly   344 AAAAANENLVGTSLYTCNHCQFKSTDKVVFDEHMRK-HAAGKPKPFKCRLC-------------- 393
                     :.|:.:.|..|:|.:.....:.||::| |...:|:.:.|.||
  Fly   223 ---------INTNNFQCPECEFHAKFPKPYKEHLQKEHGLQRPRIYPCTLCIKTFGVLKTLKNHL 278

  Fly   394 ----SQRFETREAAT-----------------VHAKQHQTNF------------------FKCGT 419
                |:.||: ||.|                 :.||..:||.                  .||..
  Fly   279 RDTHSRTFES-EAKTKAKESKEKEAKSGAKNKIDAKAKETNAVSQRKKPKEKKSKEKKTEIKCNV 342

  Fly   420 CSMTFPKREMLVKH-----FEVHQSPSASTVSPKQSVSQNLNTQKLLQETIDEALSDSLPASTAA 479
            .:....:.:..|.:     .|......|:.::..::::::|..:::|:..||...:.::..|:|
  Fly   343 ETKVVDEIDDQVNNKKGTDSEDADQTQATKIASFKALNESLMKKRMLENVIDSEYTFAINGSSA- 406

  Fly   480 VVATTESENNIRFFSCSICSLTFIQETYYNHHMET-HRRDKK------------AT--------- 522
              :|..:::|  .|.|.||....:.......||:| |..||.            ||
  Fly   407 --STPRADSN--NFQCEICDCELMTAKQMQEHMKTVHSIDKPKVFKCHVCEKSLATKQSLKTHMT 467

  Fly   523 --SAGATALNSAATALLSDEPGEATGKAGDESGEQNAEADIESLFEKLHSDKNESGEAPKPGSKG 585
              :.||.|.||:...:|.||         ||..:......||:..||:...| :|.::|...:|.
  Fly   468 LHADGAEAPNSSKRKILQDE---------DEDVDILGTTQIENTAEKVEGPK-KSQQSPTKAAKF 522

  Fly   586 GEMVI------------------TSQEGSGGI------TFNITIPQPDGDQSQKDSP----NTTA 622
            ....|                  |:::..|..      :.|....|.||......||    ..|:
  Fly   523 TNRKILQEEDEVVEIVDAFKTDNTAEDDEGPAEEKIIRSRNNIQHQVDGGMIAPRSPAKKTKKTS 587

  Fly   623 PVSVSIDMPNLDQAEDESQSQGSIDAKGESGEASSADSKSNAAPVSMPSLDDD-----------N 676
            .|.:|:           |.:.|:..||.|..:      |.:.:..::||.|.|           :
  Fly   588 HVDLSV-----------STTNGNSPAKSEKRK------KQDKSEDTLPSSDVDIVEEINYNVRPH 635

  Fly   677 EAAAAE----AEASEETKTASKAGQ-EKAKAKAGESAKSKEAA 714
            :.|..|    :.|.|.|.:..:.|: .|::.:.....:.|.||
  Fly   636 KKARLESIGDSTADESTLSCDRCGKFVKSRQRLDSHMEKKHAA 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	4/21 (19%)
		C2H2 Zn finger	268..289	CDD:275371	2/20 (10%)
		C2H2 Zn finger	297..318	CDD:275371	1/20 (5%)
		C2H2 Zn finger	360..380	CDD:275368	6/20 (30%)
		zf-H2C2_2	373..399	CDD:290200	10/44 (23%)
		zf-C2H2_8	375..443	CDD:292531	22/126 (17%)
		C2H2 Zn finger	390..410	CDD:275368	11/54 (20%)
		C2H2 Zn finger	417..437	CDD:275368	3/24 (13%)
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	6/20 (30%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	2/19 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440015
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930