DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and Zfp462

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	XP_038966959.1	Gene:	Zfp462 / 362522	RGDID:	1562123	Length:	2565	Species:	Rattus norvegicus

Alignment Length:	762	Identity:	141/762 - (18%)
Similarity:	244/762 - (32%)	Gaps:	251/762 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 DAESGGVGIGGLATRCYICDDRCEPQTSLTDMCTTHTSTKFPNKLAQLVGEGFLVIVCG-----E 127
            :.|.....|..|..||..|   .:...|..::...|.:......|.:    .|:::..|     .
  Rat  1831 EVEGEAQDIEWLPFRCIKC---FKLSFSTAELLCMHYTDHHSRDLKR----DFVILGSGPRFQNS 1888

  Fly   128 DYVCSRC----------TNLVNYY-DRLENDVERVKTNLISLLNKKYAIN--EDMGQ-------E 172
            .:.|..|          |:.:|.: :..:...:|.:.....|..:|||..  .|..|       |
  Rat  1889 TFQCKHCDSKLQSTAELTSHLNIHNEEFQKRAKRQERRKQLLSKQKYADGAFADFKQERPFGHLE 1953

  Fly   173 GSPPLKMQKMVGGSANRSLEESPSADLLRP-----RKLLQ------------------------- 207
            .:|.:|.:|:||......:|..|:   ||.     ||.:|
  Rat  1954 EAPKIKERKVVGYKCKFCVEVHPT---LRAICNHLRKHVQYGSVPAVSAAVKQEAEDPSHLFLDG 2015

  Fly   208 --------GNPVG-------------QSKIAPG--------TTQSSVQGTQTVQRKATKI----- 238
                    |..||             :.:..||        ....|:||.::.:|....:
  Rat  2016 FEAARDASGTLVGRVDGGHCLLDGMLEDETRPGGYHCSQCDRVLMSMQGLRSHERSHLALAMFTR 2080

  Fly   239 ---YKCTSCDYKTSDMRLFNTHYET--CKQQTFQCKTCRKIFPHFGAMKQHMVRDHNTAMDNTCA 298
               |.|..|.:.::.....:.|.:|  ...:.|:||.|.....:...:|.|:::.|.......|:
  Rat  2081 EDKYSCQYCSFVSAFRHNLDRHMQTHHGHHKPFRCKLCSFKSSYNSRLKTHILKAHAGEHAYKCS 2145

  Fly   299 MCH-----INFVNENSLRKH-------------METNHATNVLVTSTTTIPASAAPVAAAAA--- 342
            .|.     |:.:.|:||:.|             :.::||.:   :|....||.....:..::
  Rat  2146 WCSFSTMTISQLKEHSLKVHGKALTLPRPRIVSLLSSHAHH---SSQKATPAEEVEDSNDSSYSE 2207

  Fly   343 ------------AAAAAANENLV------GTSLYT---------CNHCQFKSTDKVVFDEHMRKH 380
                        :||.|.|.:.|      ||:..|         |..|:|.|........|.|..
  Rat  2208 PPDVQQQLNHYQSAALARNNSRVSPVPPSGTAAGTEQKAEAVLHCEFCEFSSGYIQSIRRHYRDK 2272

  Fly   381 AAGKPKPFKCRLCSQRFETREAATVHAK-------QHQTNFFKCGTCSMTFPKREMLVKHFEVHQ 438
            ..|| |.|||:.||.....:.|.|:|.:       :......:|..|......:..::.|..:|:
  Rat  2273 HGGK-KLFKCKDCSFYTGFKSAFTMHVEAGHSAVPEEGPKDLRCPLCLYHTKYKRNMIDHIVLHR 2336

  Fly   439 SPSASTVSPKQSVSQNLNTQKLLQETI------------DEALSDSLPASTAAVVATTESENNIR 491
            .   ..|.|.:.....|:  |.||..:            ||:|...:           |..|.:|
  Rat  2337 E---ERVVPIEVCRSKLS--KYLQGVVFRCDKCTFTCSSDESLQQHI-----------EKHNELR 2385

  Fly   492 FFSCSICSLTFIQETYYNHHMETHRRDKKATSAGATALNSAATALLSDEPGEATGKAGDESGEQN 556
            .:.|.:|    ..||.:...::||.||:...|...                |..|:...:..||.
  Rat  2386 PYKCQLC----YYETKHTEELDTHLRDEHKVSRNF----------------ELVGRVNLDQLEQM 2430

  Fly   557 AEADIESLFEKLHSDKNESGEAPKPGSKGGEMVITSQEGSG------------------------ 597
            .|.     .|...||..:..:.....::..|::..|..|:|
  Rat  2431 KEK-----MESSSSDDEDKDDEMSSKTEDRELMRFSDRGAGVNTEKRFPCEFCGRAFSQGSEWER 2490

  Fly   598 -----GITFNITIPQPDGDQSQKDSPNTTAPVSVSIDMPNLDQAEDE 639
                 |:..:      |.||..:|..:|...|..|:.:|:::..||:
  Rat  2491 HVLRHGMALH------DTDQVSRDEIHTKEMVEDSMQLPSIEAKEDD 2531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	4/23 (17%)
		C2H2 Zn finger	268..289	CDD:275371	5/20 (25%)
		C2H2 Zn finger	297..318	CDD:275371	7/38 (18%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..399	CDD:290200	10/25 (40%)
		zf-C2H2_8	375..443	CDD:292531	17/74 (23%)
		C2H2 Zn finger	390..410	CDD:275368	6/26 (23%)
		C2H2 Zn finger	417..437	CDD:275368	3/19 (16%)
Zfp462	XP_038966959.1	C2H2 Zn finger	2052..2072	CDD:275368	4/19 (21%)
		zf-H2C2_5	2084..2108	CDD:404746	5/23 (22%)
		C2H2 Zn finger	2086..2106	CDD:275368	3/19 (16%)
		C2H2 Zn finger	2115..2136	CDD:275368	5/20 (25%)
		C2H2 Zn finger	2144..2165	CDD:275368	6/20 (30%)
		C2H2 Zn finger	2315..2335	CDD:275368	3/19 (16%)
		C2H2 Zn finger	2361..2381	CDD:275368	4/30 (13%)
		C2H2 Zn finger	2389..2410	CDD:275368	8/24 (33%)
		C2H2 Zn finger	2475..2495	CDD:275368	0/19 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010