DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and CG18011

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_610559.1	Gene:	CG18011 / 36068	FlyBaseID:	FBgn0033491	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	835	Identity:	148/835 - (17%)
Similarity:	255/835 - (30%)	Gaps:	242/835 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 DDRCEPQTS------LTDMCTTHTSTKFPNKLAQLVGEGFLVIVCGEDYVCSRCTNLVNYYDRLE 145
            ||..|.:||      ..|:.........|..||.:|...|..:......||..|:.....::
  Fly   283 DDIDEGETSNVVLFNFVDIKEKDEVDNIPEYLATVVKTSFEKLTFQWCTVCKHCSLKCPTFE--- 344

  Fly   146 NDVERVKTNLISLLNKKYAINEDMGQ---EG-SPPLKMQKMVGGSANRSLEESPSADL------- 199
                    :|.|.|:|.:....|:.:   || :..||.:|.:  :.:..|..:|.|::
  Fly   345 --------SLFSHLSKAHKSRRDVYECPIEGCNKELKGRKFL--AMHLVLLHAPVAEIPIYGSCP 399

  Fly   200 ---LRPRKLLQGNPVGQSKIAPGTTQSSVQGTQTVQRKATKIYKCTSCDYKTSDMRLFNTH--YE 259
               |....:||.|....:.:..             :::..:.| |..|..:....:.||.|  :.
  Fly   400 ECKLTFSNILQYNKHSCAHVIK-------------KKRGFRSY-CEMCSLEFPSWKRFNFHSQFH 450

  Fly   260 TCKQQTFQCKTCRKIFPHFGAMKQHMVRDHNTAMDNTCAMCHINFVNENSLRKHMETNHATNVLV 324
            ..|.:...|..|.....:...:.||:...|.......|.:|...|.:.:...:| ..:||.   |
  Fly   451 LEKHRPRACFVCDYATTNIDELFQHLNYSHEPVGTLFCDLCDRTFRDPSVFMEH-NKSHAN---V 511

  Fly   325 TSTTTIPASAAPVAAAAAAAAAAANENLVGTSLYTCNHCQFKSTDKVVFDEHMRKHAAGKPKPFK 389
            :|||                             |:|:.|......:...:.|||   |.......
  Fly   512 SSTT-----------------------------YSCSECMANFESRGRLNGHMR---AMHGSVIS 544

  Fly   390 CRLCSQRFETREAATVHAKQH---QTNFFKCGTCSMTFPKREMLVKHFEVHQSPSASTVSPKQSV 451
            |.|||:.|.|.....:|.|:|   :.:...|.||.:....||.|:.|..     |..|.    ..
  Fly   545 CELCSREFATEATYNIHMKKHLIIEKDVHVCSTCGLLSDSRETLLAHVN-----SVKTA----CF 600

  Fly   452 SQNLNTQKLLQETIDEALSDSLPASTAAVVATTESENNIRFFSCSICSLTFIQETYYNHHM---- 512
            ...::.:.|....:.|..|.................:....|.|..|...|.....|.||:
  Fly   601 GSKIDVELLRDAYVCEYCSSYFKEKDCLQAHRDSGVHKDGVFLCQPCGKEFPHMKLYRHHLRNYQ 665

  Fly   513 -----ETHRR---------DKKATSAGATALNSAATALLSDEPGEATGKAGDESGEQNAEADIES 563
                 .||||         |::..:......||..|
  Fly   666 QLRSDSTHRRLEICVYYMCDQENCTESYVNWNSLYT----------------------------- 701

  Fly   564 LFEKLHSDKNESGEAPKPGSKGGEMV--ITSQEGSGGITFNITIPQPDGDQSQKDSPNTTAPVSV 626
              .|..:.::.|.:|.|......|.|  ...:|....::.::.:.:      ..::.|.|.|:..
  Fly   702 --HKRRTHESASKQAEKSSKSAQEWVCQFCLKECRSKMSLSVHVAR------SHNNDNVTCPLCN 758

  Fly   627 SIDMPNLDQAEDESQSQGSIDAKGESGEASSADSKSNA---APVSMPSL--------DDDNEAAA 680
            |                        |.::..|.:|.:|   .|:..|..        :.|.....
  Fly   759 S------------------------SYKSHDALAKHHAYWHEPIECPECFKIVKNRRNYDTHVNV 799

  Fly   681 AEAEASEETKTASKAG-QEKAKAKA-----GESAKSKEAAAAEEPQPSDEGDVVA---KREATDT 736
            ..:.....:.:..:.| ..|::.:|     |:|...::.:.....:.|....|:.   ||.|
  Fly   800 VHSNKKRYSCSVCQKGFYHKSEMEAHQKLHGQSYSCEQCSFTTRNKKSLSVHVLGQHYKRFA--- 861

  Fly   737 PTTESEANATTAEAGESGEGEVTASTGAEGEAGEAA----GG------------EHV-------- 777
                .|.|......|.| :|..|....|.|:.....    ||            .||
  Fly   862 ----FECNVCKKRFGRS-QGLKTHMQRAHGDKYTCRDYFDGGCGRTFVNSSQLNVHVRKIHDGII 921

  Fly   778 -----AMELDEAMQAQVEGGQIKFIVNENGHLLQLDNHILTDAEGNQIIVQDPEQ 827
                 .:|.||.:.........|..:|||       |..:.:|:|:.|:::|.::
  Fly   922 LLQEDVVEEDEYITDDAPSTSKKRRLNEN-------NEFIEEADGDDIVMEDDDE 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	5/23 (22%)
		C2H2 Zn finger	268..289	CDD:275371	4/20 (20%)
		C2H2 Zn finger	297..318	CDD:275371	4/20 (20%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		zf-H2C2_2	373..399	CDD:290200	9/25 (36%)
		zf-C2H2_8	375..443	CDD:292531	21/70 (30%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	417..437	CDD:275368	7/19 (37%)
CG18011	NP_610559.1	PRK14950	<98..>184	CDD:237864
		C2H2 Zn finger	488..508	CDD:275368	4/20 (20%)
		C2H2 Zn finger	518..538	CDD:275368	5/22 (23%)
		C2H2 Zn finger	545..565	CDD:275368	8/19 (42%)
		C2H2 Zn finger	575..596	CDD:275371	8/25 (32%)
		SFP1	<682..747	CDD:227516	11/101 (11%)
		C2H2 Zn finger	754..775	CDD:275368	6/44 (14%)
		C2H2 Zn finger	780..801	CDD:275368	2/20 (10%)
		C2H2 Zn finger	809..829	CDD:275368	3/19 (16%)
		C2H2 Zn finger	864..885	CDD:275368	5/21 (24%)
		C2H2 Zn finger	891..917	CDD:275368	4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440061
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930