DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pzg and CG9932

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_609599.1	Gene:	CG9932 / 34701	FlyBaseID:	FBgn0262160	Length:	2171	Species:	Drosophila melanogaster

Alignment Length:	1083	Identity:	207/1083 - (19%)
Similarity:	343/1083 - (31%)	Gaps:	331/1083 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 ATRCYICDDRCEPQTSLTDMCTTHTSTKFPNKLAQLVGEGFLVIVCGEDYVCSRCTNLVNYYDRL 144
            :|||..|..||:            :||...:.|.|          |.|   ..||.|  ..||..
  Fly   677 STRCQHCRHRCK------------SSTDLMHHLKQ----------CVE---AIRCAN--EMYDSN 714

  Fly   145 ENDVERVKTNLISLLNKKYAINEDMGQEGSPPLKMQKMVGGSANRSLEESPSADLLRPRK--LLQ 207
            ..:....:.:..||            |:.:...:.:..:...|.:.:..:.:|.|.:.:.  .|.
  Fly   715 SGESGDRRPDSQSL------------QQQAAVQQQRVCIWNKATKEIIAAAAASLQQDKNNHNLV 767

  Fly   208 GNPVGQSKIAPGTTQSSVQGTQT------VQRKAT-----------KIYKCTSCDYKTSDMRLFN 255
            .:|.|..  |....::|..|.:|      |.:|.|           |:|||..|.:..|....|:
  Fly   768 KSPTGSQ--AASNEENSYYGVETAPGYGEVTKKMTPEEEAANSSLKKVYKCPHCSFWASTASRFH 830

  Fly   256 TH-YETCKQQTFQCKTCR-------KIFPHFGAMKQHMVRD--HNTAM----DNTCAMCHINFVN 306
            .| .....::.|:|..|.       .|..|   ::...:||  |.||.    |.|....:..:..
  Fly   831 VHIVGHLNKKPFECSLCSYRSNWRWDITKH---IRLKTIRDPSHKTAKVLMNDETGRRNYTKYNK 892

  Fly   307 ENSLRKHMETNHATNVLVTSTTTIPASAAPVA-----AAAAAAA-------------------AA 347
            ..:|.|..|.:....::.:...| |...|.:|     |...:.:                   |.
  Fly   893 YITLMKVTEEDGDPKLMKSGEMT-PNQVASLAFLKDYAKVGSVSGQDITLEPVLPNKPNVLDDAH 956

  Fly   348 ANENLVGTSLYTC-----------------NHCQFKSTDKVVFDEHMRKHAA----GKPKP---- 387
            ..:||:...|...                 .|.....|..|......|.:.|    |||..
  Fly   957 LADNLIRIPLLATMMNAAMAQQQHQQQQQKEHQSTMITPSVTISPVKRSNQASVMQGKPSDDLIT 1021

  Fly   388 ------------FKCRLCSQRFETREAATVHAKQHQTNFFKCGTCSMTFPKREMLVKHFEVHQSP 440
                        ::||.|:...:.|:|...|.|.|..:        .::||           .:.
  Fly  1022 EVHQEGNEKRTVYRCRKCNFGHQNRDAVLAHVKIHYQD--------ASYPK-----------SNS 1067

  Fly   441 SASTVSPKQSVSQNLNTQKLLQET-----IDEALSDSLPASTAAVVATTESENNIRFFSCSICSL 500
            ..|:.||.| ||...:.|..:.:.     :.:..|.|.|.|.:|..:...|...::
  Fly  1068 GNSSTSPLQ-VSVGGSPQFYMNKVFAAMCLSQTQSQSSPNSGSAGTSPAISAGLLQ--------- 1122

  Fly   501 TFIQETYYNHHMETHRRDKKATSAGATALNSAATALLSDEPGEATGKAGD----ESGEQNA---E 558
            ..|||..:            :.:..|:||:..|.||...:|...|.||..    |.|||.|   |
  Fly  1123 RAIQEAQH------------SPTPNASALSGLALALAGGKPQANTTKASAASILEHGEQKASQNE 1175

  Fly   559 ADIESL-----------------------FEKLHSDKNESGEAPKPGSKGGEMVITSQEGSG--- 597
            |..:||                       .:.|.:....:.....|.:.....|:    |:|
  Fly  1176 ASADSLTSPNTTTTNSTTSRTTKDTTARSLQDLLTSPRSARNGNHPSNANSNSVV----GNGLRL 1236

  Fly   598 ------GITFNITIPQPDGDQSQKDSPN------TTAPVSVSIDMP--------NLDQAEDESQS 642
                  ..|.|.|.|.|....| ...||      ||.|..:|...|        |...:......
  Fly  1237 DAVYVASSTNNTTTPPPPPTNS-VSKPNASPLPVTTTPTPISTATPLAHPLGAGNHRSSSSHHND 1300

  Fly   643 QGSIDAKGESGEAS------------SADSKSNAAPVSMPSLDDDNEAAAAEAEASEETKTASKA 695
            |........:|:..            :.::|:|.:..|.||       :::.:.:|....|:|.|
  Fly  1301 QNHAPPSHMAGDGCHLASGLTHAHIINTNTKANPSSNSFPS-------SSSSSSSSSMASTSSAA 1358

  Fly   696 GQEKAKAKAGESAKSKEAAAAEEPQPSDEGDVVAKREATDTPTTESEANATTAEAGESGEGEVTA 760
            |...|.|.:..|:....||::     |....:.|.......||....::..|.....| .|..:.
  Fly  1359 GSASASASSTTSSPPPPAASS-----SASAYMAAMAPQKHVPTVAQMSHPQTRFHSHS-PGSPSL 1417

  Fly   761 STGAEGEAGEAAGGEHVAMELDEAMQAQVEGGQIKFIVNENGHLLQLDN--HILTDAEGNQIIVQ 823
            .|.|:|:..|.:                         ....||..|:.|  |::.
  Fly  1418 LTMADGDRREPS-------------------------PYRCGHCHQVSNWKHVIQ---------- 1447

  Fly   824 DPEQIQQLLQSVGVLQSGEGLEGETLQMMTDGSGQMVLVH-----GDNNEQQLIDASLLNSEGQL 883
                     :...:..||: :..|||:.....|.....::     |.:||.|....:..|.....
  Fly  1448 ---------RHCRLKHSGD-IRIETLERGASVSANAPPIYRPLGAGASNESQSHIHNPSNPITSN 1502

  Fly   884 IIQQGQDGEEGAHVISEDGTRIPVSVSYTED--GQPIVQVQQQVLEAAQ-----QAASASGGADD 941
            |::.|.:....:::.|.....:.::....|.  ..|:......|:.||.     |||:|...|..
  Fly  1503 ILKSGSNTNANSNINSNSAQPLLLTTKQLEQIFHTPLSASAAAVVNAANTQQDIQAAAAYWAAAC 1567

  Fly   942 KEAAADSAGEE-VQVSEASSGTASTTVVATSTASSTGGPSGGS 983
            |...|:|:.|| :|:.:  :.....|.:.|:|..|.|. ||.:
  Fly  1568 KAVVANSSAEELLQLQQ--NDQIEITRLPTTTEHSIGS-SGNN 1607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	5/22 (23%)
		C2H2 Zn finger	268..289	CDD:275371	6/29 (21%)
		C2H2 Zn finger	297..318	CDD:275371	3/20 (15%)
		C2H2 Zn finger	360..380	CDD:275368	4/36 (11%)
		zf-H2C2_2	373..399	CDD:290200	8/45 (18%)
		zf-C2H2_8	375..443	CDD:292531	15/87 (17%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	417..437	CDD:275368	2/19 (11%)
CG9932	NP_609599.1	C2H2 Zn finger	339..359	CDD:275368
		C2H2 Zn finger	366..386	CDD:275368
		C2H2 Zn finger	394..414	CDD:275368
		C2H2 Zn finger	816..836	CDD:275370	5/19 (26%)
		C2H2 Zn finger	844..862	CDD:275370	4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100