Protein Alignment pzg and ZNF181

DIOPT Version :10

• Sequence 1: NP_649297.1
• Gene: pzg / 40351
• FlyBaseID: FBgn0259785
• Length: 996
• Species: Drosophila melanogaster
• Sequence 2: NP_001025168.2
• Gene: ZNF181 / 339318
• HGNCID: 12971
• Length: 571
• Species: Homo sapiens
• Alignment Length: 629
• Identity: 117/629 - (18%)
• Similarity: 218/629 - (34%)
• Gaps: 181/629 - (28%)

  Fly    74 VGIGGLA-TRCYI---CDDRCEP---QTSLTDMCTTHTSTKFPNKLAQLVGEGF-------LVI- 123
            |.:.||: |:.|:   .:|..||   :..|:........:::.||......:.:       ::|
Human    41 VSVAGLSVTKPYVITLLEDGKEPWMMEKKLSKGMIPDWESRWENKELSTKKDNYDEDSPQTVIIE 105

  Fly   124 -VCGEDYVCSRCTNLVNYYDRLE----NDVERVKTNLI------------------SLLNKKYAI 165
             |..:.|..|.....:.|.::||    :.|:..:..::                  |..:.|..:
Human   106 KVVKQSYEFSNSKKNLEYIEKLEGKHGSQVDHFRPAILTSRESPTADSVYKYNIFRSTFHSKSTL 170

  Fly   166 NE-------------DMGQEGSPP---LKMQKMVGGSANRSLEESPSADLLRPRKLLQGNPVGQS 214
            :|             |:.::..|.   :|.:|:.||                 :|||..|..|
Human   171 SEPQKISAEGNSHKYDILKKNLPKKSVIKNEKVNGG-----------------KKLLNSNKSG-- 216

  Fly   215 KIAPGTTQSSVQGTQTVQRKATKIYKCTSCDYKTSDMRLFNTHYET-CKQQTFQCKTCRKIFPHF 278
              |..:...|:...||..|:  |||.|:.|........:.|.|:.. ..::.::|:.|.|.|.|.
Human   217 --AAFSQGKSLTLPQTCNRE--KIYTCSECGKAFGKQSILNRHWRIHTGEKPYECRECGKTFSHG 277

  Fly   279 GAMKQHMVRDHNTAMDNTCAMCHINFVNENSLRKHMETNHATNVLVTSTTTIPASAAPVAAAAAA 343
            .::.:|:: .|:......|..|...|.:.:||..|..|:
Human   278 SSLTRHLI-SHSGEKPYKCIECGKAFSHVSSLTNHQSTH-------------------------- 315

  Fly   344 AAAAANENLVGTSLYTCNHC--QFKSTDKVVFDEHMRKHAAGKPKPFKCRLCSQRFETREAATVH 406
                     .|...|.|.:|  .|.....::  ||:|.|.  :.|.::||:|.:.|..|.:...|
Human   316 ---------TGEKPYECMNCGKSFSRVSHLI--EHLRIHT--QEKLYECRICGKAFIHRSSLIHH 367

  Fly   407 AKQHQ-TNFFKCGTCSMTFPKREMLVKHFEVHQSPSASTVSPKQSVSQNLNTQKLLQETIDEALS 470
            .|.|. ...::|..|...|.....|.:|..:|            ::.:.....|.|:
Human   368 QKIHTGEKPYECRECGKAFCCSSHLTRHQRIH------------TMEKQYECNKCLK-------- 412

  Fly   471 DSLPASTAAVVATTESENNIRFFSCSICSLTFIQETYYNHHMETHRRDKKATSAGATALNSAATA 535
              :.:|.:.:|.........:.|.|..|..:|.|....|.|:..|.|.|....:......|..::
Human   413 --VFSSLSFLVQHQSIHTEEKPFECQKCRKSFNQLESLNMHLRNHIRLKPYECSICGKAFSHRSS 475

  Fly   536 LL-------SDEPGEATGKAGDESGEQNAEADIESLFEKLHSDK-----NESGEAPKPGSKGGEM 588
            ||       .::|.|..     :.|:..:.:...::.:::|:.:     ||.|:|   .|||..:
Human   476 LLQHHRIHTGEKPYECI-----KCGKTFSCSSNLTVHQRIHTGEKPYKCNECGKA---FSKGSNL 532

  Fly   589 VITSQEGSGGITFNITIPQPDGDQSQKDSPNTTAPVSVSIDMPN 632
            ....:..:|                  :.||:...|...:|..|
Human   533 TAHQRVHNG------------------EKPNSVVSVEKPLDYMN 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_649297.1	C2H2 Zn finger	241..263	CDD:275371	4/22 (18%)
		C2H2 Zn finger	268..289	CDD:275371	6/20 (30%)
		C2H2 Zn finger	297..318	CDD:275371	7/20 (35%)
		C2H2 Zn finger	360..380	CDD:275368	6/21 (29%)
		zf-H2C2_2	373..399	CDD:463886	9/25 (36%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
ZNF181	NP_001025168.2	KRAB	4..65	CDD:214630	8/23 (35%)
		COG5048	211..>539	CDD:227381	80/403 (20%)
		C2H2 Zn finger	239..259	CDD:275368	4/19 (21%)
		C2H2 Zn finger	267..287	CDD:275368	6/20 (30%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		C2H2 Zn finger	323..343	CDD:275368	6/21 (29%)
		C2H2 Zn finger	351..371	CDD:275368	7/19 (37%)
		C2H2 Zn finger	379..399	CDD:275368	5/19 (26%)
		C2H2 Zn finger	407..427	CDD:275368	4/29 (14%)
		C2H2 Zn finger	435..455	CDD:275368	6/19 (32%)
		C2H2 Zn finger	463..483	CDD:275368	3/19 (16%)
		C2H2 Zn finger	491..511	CDD:275368	1/24 (4%)
		C2H2 Zn finger	519..539	CDD:275368	7/22 (32%)