DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pzg and Zfp335

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	XP_030107665.1	Gene:	Zfp335 / 329559	MGIID:	2682313	Length:	1338	Species:	Mus musculus

Alignment Length:	1184	Identity:	212/1184 - (17%)
Similarity:	334/1184 - (28%)	Gaps:	469/1184 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PATYRKFNNLLSSGAVTVTGPSQPRILKSTRMVVPGGGGGGGASAGGASAVG---------GVAQ 62
            |...||...|.:|.  ...|..||.:...:....|........|:.|..|:|         ||:|
Mouse   357 PGRPRKLPRLETSD--LHDGVGQPLVSSQSTQSPPELQDLEAPSSSGLRALGKVGRGLVESGVSQ 419

  Fly    63 QQAVNDAESGGVGIGGLATRCYICDDRCEPQTSLTDMCTTHTSTKFPNKLAQLVGEGFLVIVCGE 127
            ..|.|.|.|              |.|..:.                |.:........||    |:
Mouse   420 SDAENAAPS--------------CQDEADA----------------PPRRRGRPSRRFL----GK 450

  Fly   128 DYVCSRCTNLVNYYDRLENDVERVKTNLISLLNKKYAINEDM------GQEGSPPLKMQKMVGGS 186
            .|        ..||.:....:  ::..|..:...::..:||:      .:.|.|.|.........
Mouse   451 KY--------RKYYYKSPKPL--LRPYLCRICGSRFLSHEDLRFHVNSHEAGDPQLFRCLQCSYR 505

  Fly   187 ANR--SLEESPSADLLRPRKLLQGNPVGQSKIAPGTTQSSVQGTQTVQRKATKIYKCTSCD---- 245
            :.|  ||:|.            ..|.||                       :|.|||..|.
Mouse   506 SRRWSSLKEH------------MFNHVG-----------------------SKPYKCDECSYTSV 535

  Fly   246 YKTSDMRLFNTHYE--------TCKQQTFQCKTCRKIFPHFGAMKQHMVRDHNTAMDNTCAMCHI 302
            |:...:|....|.:        |.|..:|.|..|.:::|....:.||| :.|:|...:.|..|..
Mouse   536 YRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHM-KTHSTEKPHMCDKCGK 599

  Fly   303 NFVNENSLRKHMETNHATNVLVTSTTTIPASAAPVAAAAAAAAAAANENLVGTSLYTCNHCQFKS 367
            :|....:.:.|:.|:                          ..|.||..      :.|..|:|..
Mouse   600 SFKKRYTFKMHLLTH--------------------------IQAVANRR------FKCEFCEFVC 632

  Fly   368 TDKVVFDEHMRKHAAGKPKPFKCRLCSQRFETREAATVHAKQHQTNF--FKCGTCSMTFPKREML 430
            .||.....|...|.:  .|||||..|..|....:....|.....|..  |.|..|..:...::.|
Mouse   633 EDKKALLNHQLSHVS--DKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFACEYCHFSTRHKKNL 695

  Fly   431 VKHFEVHQSPSASTVSPKQSVSQNLNTQKLLQETIDEALSDSLPASTAAVVATTESENNIRFFSC 495
            ..|.....:.|......:..               :|..|...|                 ||
Mouse   696 RLHVRCRHANSFEEWGRRHP---------------EEPPSRRRP-----------------FF-- 726

  Fly   496 SICSLTFIQETYYNHHMETHRRDKKATSAGATALNSAATALLSDEPGEATGKAGDESGEQNAEAD 560
               ||..|:|....|                           |..||......|.|:.::.|..
Mouse   727 ---SLQQIEELKQQH---------------------------STAPGPPLSSPGPEAPQEPAPF- 760

  Fly   561 IESLFEKLHSDKNESGEAPK---PGSKGGEMVI-----------------------TSQEGSGGI 599
                         :|.|.|.   |.:.||..:|                       ::|...|..
Mouse   761 -------------QSPETPPLLCPDALGGTTIIYQQGAEESTAVATQTALDLLLNMSAQRELGAT 812

  Fly   600 TFNITIPQPDGDQSQ------KDSPNTTAPVSVSIDMPNLDQAEDESQSQGSIDAKGESGEASSA 658
            ...:.:.:.:|.:::      :.||..|.|..|::.|                   .|||.:.:|
Mouse   813 ALQVAVVKSEGIEAELTSTGGQPSPEDTTPRVVTLHM-------------------AESGSSVAA 858

  Fly   659 DSK---SNAAPVSMPSLDDDNEAAAAEAEASEETKTASKAGQEKAKAKAGESAKS-------KEA 713
            :|:   |:...:::||......:.:.......|.:| |.:|....:...||:|::       |||
Mouse   859 ESQLGPSDLQQIALPSGPFGGASYSVITAPPVEGRT-SASGPPYREEPPGEAAQAVVVSDTLKEA 922

  Fly   714 A-----AAEEPQ----------------------------------PSDEGDVVAK--------R 731
            .     ||:..|                                  |.|..:|::.        .
Mouse   923 GTHYIMAADGTQLHHIELTADGSISFPSPDTLAPGTKWPLLQCGGPPRDGSEVLSPTKTHHMGGS 987

  Fly   732 EATDTP--------------TTESEANATTAE-----AGESGEGEVTASTGAEGEAGEAA----- 772
            :.:.||              :..|.|.::|.:     ..|:........:.....||.||
Mouse   988 QGSSTPPPAASHTLGLVVPQSPPSAAASSTKKFSCKVCSEAFPSRAEMESHKRAHAGPAAFKCPD 1052

  Fly   773 --------------GGEHVAMELDEAMQAQVEGGQIKFI---------------------VNENG 802
                          ..:|.::...:..|........|.:                     .|.||
Mouse  1053 CPFSARQWPEVRAHMAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHTNEKPFSCHVCGQRFNRNG 1117

  Fly   803 HLLQLDNHI--LTDAEGNQ------------IIVQDPEQIQQLLQSVGVLQSGEGLEG-ETLQ-- 850
            |   |..||  |...:|.:            ||:...|:....|.:  ..||..|:.| |.||
Mouse  1118 H---LKFHIQRLHSIDGRKTGTSTARAPAQTIILNSEEETLATLHT--AFQSSHGVLGTERLQQA 1177

  Fly   851 -------------------------MMTDGSGQMVLVHGDNNEQQLIDAS----LLNSEGQLI-- 884
                                     :..||.....||..||..|.:|...    ||..|..::
Mouse  1178 LSQEHIIVAQEQTVTNQEEATYIQEITADGQTVQHLVTSDNQVQYIISQDGVQHLLPQEYVVVPD 1242

  Fly   885 -----IQQGQDGEEGAHVISEDGTRIPVSVSYTEDGQ----PIVQVQQQVLEAAQQAASASGGAD 940
                 :|:||.    .|:..|.||      .:.::.|    |:...||.|.:|..:||:.|.
Mouse  1243 GHHIQVQEGQI----THIQYEQGT------PFLQESQIQYVPVSPSQQLVTQAQLEAAAHSA--- 1294

  Fly   941 DKEAAADSAGEEVQ 954
             ..|.||:|..:.|
Mouse  1295 -VTAVADAAMAQAQ 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	6/33 (18%)
		C2H2 Zn finger	268..289	CDD:275371	6/20 (30%)
		C2H2 Zn finger	297..318	CDD:275371	5/20 (25%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..399	CDD:290200	9/25 (36%)
		zf-C2H2_8	375..443	CDD:292531	17/69 (25%)
		C2H2 Zn finger	390..410	CDD:275368	4/19 (21%)
		C2H2 Zn finger	417..437	CDD:275368	4/19 (21%)
Zfp335	XP_030107665.1	zf-H2C2_5	248..268	CDD:372805
		C2H2 Zn finger	469..489	CDD:275368	2/19 (11%)
		C2H2 Zn finger	499..519	CDD:275368	4/31 (13%)
		zf-H2C2_2	511..536	CDD:372612	11/59 (19%)
		zf-H2C2_5	525..548	CDD:372805	6/22 (27%)
		C2H2 Zn finger	527..547	CDD:275368	4/19 (21%)
		C2H2 Zn finger	566..586	CDD:275368	6/20 (30%)
		zf-H2C2_2	578..603	CDD:372612	8/25 (32%)
		C2H2 Zn finger	594..614	CDD:275368	4/19 (21%)
		C2H2 Zn finger	625..645	CDD:275368	6/19 (32%)
		C2H2 Zn finger	653..674	CDD:275368	4/20 (20%)
		C2H2 Zn finger	682..701	CDD:275368	4/18 (22%)
		C2H2 Zn finger	1022..1042	CDD:275368	1/19 (5%)
		SFP1	<1027..1127	CDD:227516	15/102 (15%)
		C2H2 Zn finger	1050..1070	CDD:275368	0/19 (0%)
		zf-H2C2_5	1076..1100	CDD:372805	2/23 (9%)
		C2H2 Zn finger	1078..1098	CDD:275368	2/19 (11%)
		zf-H2C2_2	1090..1115	CDD:372612	0/24 (0%)
		C2H2 Zn finger	1106..1127	CDD:275368	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100