DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pzg and hang

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_001138204.1	Gene:	hang / 32613	FlyBaseID:	FBgn0026575	Length:	2223	Species:	Drosophila melanogaster

Alignment Length:	1258	Identity:	247/1258 - (19%)
Similarity:	422/1258 - (33%)	Gaps:	414/1258 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SSGAVTVTGPSQPRILKSTRMVVPGGGGGGGASAGGASAVGGVAQQQAVNDAES-GGVGIGGLAT 81
            ||.|..:|  |.|::....::     ||||..||..|:|    ||..|..||.: .......:..
  Fly   981 SSAAPPLT--STPKLAGGNQV-----GGGGSTSASAAAA----AQSSANRDASAPKSQYFSRMPQ 1034

  Fly    82 RCYICDDRCEPQTSLTDMCTTHTSTKFPNKLAQLVGEGFLVIVCGEDYVCSRC-----------T 135
            .|.||..:.....::    ..|..:|.||||.             |.|.|.||           .
  Fly  1035 VCPICGQQYNNYNNV----LRHMESKHPNKLP-------------ETYKCVRCGLGYPRISYLRE 1082

  Fly   136 NLVNYYDRLEN----------DVERVK------------------TNLISLLNKKYAINEDMGQE 172
            :::|.:...:|          :.:.||                  .:|:|:.|.. .::::..:.
  Fly  1083 HMINVHGVDKNRHSGGFEYIVNADAVKLADGSTPNVYTGRYDYVMKDLMSITNGG-TLDDEEEEP 1146

  Fly   173 GSPPLKMQKMVGGSANRSL-------EESP-------------------------------SADL 199
            ||...|| ::...|.|.||       :|.|                               :|:.
  Fly  1147 GSVAKKM-RLDDSSNNSSLVGVASQQKECPICNAVFSNNIGLSNHMRSHYTASNAVNAALAAANR 1210

  Fly   200 LRPRKL-LQGNPVGQSKIAPGTTQSS-----------VQGTQTVQRKAT-------------KIY 239
            :.|:.| :...|...|::..|.|.|.           ....||.|.:|.             :..
  Fly  1211 MTPKSLTITATPATDSELGVGGTMSESAPATPANVPPAMANQTPQEQAVFRRSLDQAADRRFRRM 1275

  Fly   240 KCTSCDYKTSDMRLFNTHYETCKQ----QTFQCKTCRKIFPHFGAMKQHMVRDHNTAMDN----- 295
            :|..|..:.|..:.:..|..|..|    |..:||.|...|.:...:|.|:.:.|..|:.:
  Fly  1276 RCRICQRRFSSKKSYRYHMLTDHQVQNVQFIKCKLCNAEFAYEKGLKVHLFKVHGKAIKDEMIIK 1340

  Fly   296 --TCAMCHINFVNENSLRKHMETNHATNVLVTSTTTIPAS----------AAPVAA-AAAAAAAA 347
              .|.:|.|.:.:|:.|::|..:.|.......||:...:|          ..|.:: .|..:..|
  Fly  1341 QFECDVCSIVYSSESELQQHKRSVHKLTSASASTSASTSSKIDDDSLMDDGKPTSSDLADLSTLA 1405

  Fly   348 ANENLVGTSL--YTCNHC--QFKSTDKVVFDEHMRKHAAGKPKPFKCRLCSQRFETREAATVHA- 407
            |..:.....|  |.|.:|  .|.:..|:..  |:..|.......:.|:.|...:..|::..||.
  Fly  1406 AGGSTASAPLYWYQCKYCPSNFNTNKKLAI--HINSHDEFDSNDYSCKDCGNVYSGRKSLWVHRY 1468

  Fly   408 KQHQ--TNFFKCGTCSMTFPKREMLVKHFEV-HQSPSASTVSPKQSVSQNLNTQKLLQETI---- 465
            |:|.  .|..:|..|...|..|:|...|... ::.|..||.:.:|...| |::....:.||
  Fly  1469 KKHPQVPNPAECSLCRKVFFDRQMHDNHTPTCNRKPITSTGAHQQQDGQ-LHSHHTAKRTIFRHK 1532

  Fly   466 -----------------DEALSDS-------LPASTAAVVATTESENNIRFFSCSICSLTFIQET 506
                             :.|.||.       ...||||  |.|..:..|...:|:||...|..:.
  Fly  1533 TGDDDDEEDDDEQQQLEERANSDGNGTTVGVASGSTAA--AGTSLKIRIPEVACTICGARFTDQE 1595

  Fly   507 YYNHHMETHRRDKKATSAGATALNSAATALLSDEPGEATGKAGDESGEQNAE--ADI------ES 563
            :::.|::.|.::        ..:::...|:..|.|.:| |:...|...:|.|  .|:      :.
  Fly  1596 HFSKHIQKHEQE--------LYVDNPLAAMFDDGPADA-GQFQVERQNENGEYACDLCAKTFPQV 1651

  Fly   564 LFEKLHSDKNESGEAPKPGSKGGEMVITSQEGSGGITFNITIPQPDGDQSQKDSPNTTAPVSVSI 628
            :..|:|...:..|::.:....|....:|:.        |.|.     :.:..:|.:.....:|.:
  Fly  1652 IALKVHRKWHFRGDSKQNPIDGEATQLTNN--------NHTT-----NNNNNNSMHLRELHAVGL 1703

  Fly   629 DMPNLDQAEDESQSQGSIDAKGESGEASSADSK-------------------------------- 661
             |||..|....:....|::....|....|...|
  Fly  1704 -MPNQQQQSLNNSCNSSMNHNNNSSSNRSKSMKRKRELKCEYCASTFISNNNLRRHMYELHKHEV 1767

  Fly   662 SNAAPVSMPSLDD------------------DNEAAAAEA------------------------- 683
            ||.....:..:||                  :::.|.|:.
  Fly  1768 SNLPEPPVIVVDDHLTCRRCQLKFDTKELWIEHKLADAKVVRPFCPFQWGCDLCGEYLSRKEKLM 1832

  Fly   684 -----EASEE------TKTASK--AGQEKAKAKA---------GESAKSK-------EAAAA--- 716
                 ...||      ||.|.:  |..|.|.|.|         ||.|:::       |||.|
  Fly  1833 NHINNHLKEEVIVPVATKAAIERTAAMESAAADANAAATLSALGEGAETEDQFAEKVEAAGATTT 1897

  Fly   717 -----EEPQPSDEGDVVAKREATDTPTTESEANATTAEAGESGEGEVTASTGAEGEAGEAAGGEH 776
                 .:.:.||:.|..:..:..|:..|..:.:...::..|.||||      .|.|.|:...||
  Fly  1898 DKLTNPDEEDSDDLDEDSSGDDDDSSGTGDDDDDDDSDDDEDGEGE------DEDEEGDGGEGE- 1955

  Fly   777 VAMELDEAMQAQVEGGQIKFIVNENGHLLQLDNHILTDAEGNQIIVQDPEQIQQLLQSVGVLQSG 841
                 ||      ||      |.....||....| .||...||   .|.:.:::::.|    ...
  Fly  1956 -----DE------EG------VQPPAQLLPQQQH-KTDLNLNQ---DDDDLVEEVISS----DDD 1995

  Fly   842 EGLEGETLQMMTDGSGQMVLVHGDNNEQQLID---------ASLLNSEGQ---LIIQQGQDGEEG 894
            |..:||   :.:|...:     .|::|:..::         ..|:|.:.:   ||:....|.::|
  Fly  1996 EDDDGE---VESDDDDE-----DDDDEEDDVEEPEPVGLTVRPLMNGKSKMPPLIVASSDDEDDG 2052

  Fly   895 AHVISEDGTRIPVSVSYTEDGQP-----IVQVQQQVLEAAQQAASASGGADDKEAAADSAGEEVQ 954
            ...|.:     .:...:.||..|     |.:|.:..|:        .|..:|:.....:|    .
  Fly  2053 VMPIED-----IIEEEFDEDADPDPEDAIEEVDEDDLD--------EGEVEDEPNVVSTA----S 2100

  Fly   955 VSEASSGTASTTVVATSTASSTG 977
            .||:.|.| :||..:.|.:.|||
  Fly  2101 FSESESST-TTTSNSHSHSHSTG 2122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	5/21 (24%)
		C2H2 Zn finger	268..289	CDD:275371	6/20 (30%)
		C2H2 Zn finger	297..318	CDD:275371	6/20 (30%)
		C2H2 Zn finger	360..380	CDD:275368	5/21 (24%)
		zf-H2C2_2	373..399	CDD:290200	4/25 (16%)
		zf-C2H2_8	375..443	CDD:292531	17/71 (24%)
		C2H2 Zn finger	390..410	CDD:275368	6/20 (30%)
		C2H2 Zn finger	417..437	CDD:275368	6/20 (30%)
hang	NP_001138204.1	zf-AD	80..154	CDD:285071
		C2H2 Zn finger	1036..1057	CDD:275368	4/24 (17%)
		C2H2 Zn finger	1067..1088	CDD:275368	4/20 (20%)
		C2H2 Zn finger	1279..1298	CDD:275371	4/18 (22%)
		C2H2 Zn finger	1308..1325	CDD:275371	5/16 (31%)
		C2H2 Zn finger	1420..1440	CDD:275368	5/21 (24%)
		C2H2 Zn finger	1450..1468	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455457
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930