DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and Zfp335

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_001093956.2	Gene:	Zfp335 / 259270	RGDID:	628751	Length:	1336	Species:	Rattus norvegicus

Alignment Length:	919	Identity:	174/919 - (18%)
Similarity:	268/919 - (29%)	Gaps:	333/919 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 TKIYKCTSCD----YKTSDMRLFNTHYE--------TCKQQTFQCKTCRKIFPHFGAMKQHMVRD 288
            :|.|||..|.    |:...:|....|.:        |.|..:|.|..|.:::|....:.||| :.
  Rat   520 SKPYKCDECSYTSVYRKDVIRHAAVHSQDRKKRPDPTPKLSSFPCPVCGRVYPMQKRLTQHM-KT 583

  Fly   289 HNTAMDNTCAMCHINFVNENSLRKHMETNHATNVLVTSTTTIPASAAPVAAAAAAAAAAANENLV 353
            |:|...:.|..|..:|....:.:.|:.|:                          ..|.||..
  Rat   584 HSTEKPHMCDKCGKSFKKRYTFKMHLLTH--------------------------IQAVANRR-- 620

  Fly   354 GTSLYTCNHCQFKSTDKVVFDEHMRKHAAGKPKPFKCRLCSQRFETREAATVHAKQHQTNF--FK 416
                :.|..|:|...||.....|...|.:  .|||||..|..|....:....|.....|..  |.
  Rat   621 ----FKCEFCEFVCEDKKALLNHQLSHVS--DKPFKCSFCPYRTFREDFLLSHVAVKHTGAKPFA 679

  Fly   417 CGTCSMTFPKREMLVKHF---------------------------------EVHQSPSASTVSPK 448
            |..|..:...::.|..|.                                 |:.|..||:...|.
  Rat   680 CEYCHFSTRHKKNLRLHVRCRHANSFEEWGRRHPEEPPSRRRPFFSLQQIEELKQQHSAAPGPPL 744

  Fly   449 QSVS----------QNLNTQKLLQETIDEALSDSLPASTAAVVATTESENNIRFFSCSICSLTFI 503
            .|..          |...|..||       ..|:|..:|  ::....:|.:....:.:...|..
  Rat   745 SSAGPEAPQEPAPFQPPETPPLL-------CPDALGGAT--IIYQQGAEESTAMATQTALDLLL- 799

  Fly   504 QETYYNHHMETHRRDKKATSAGATALNSAATALLSDEPGEATGKAGDESGEQNAEADIESLFEKL 568
                   :|...|      ..||||| ..|.....|...|.|..|...|.|     |.......|
  Rat   800 -------NMSAQR------ELGATAL-QVAVVKSEDVEAELTSTARQPSSE-----DTTPRVVTL 845

  Fly   569 H----------------SDKNESGEAPKPGSKGGEMVITSQ-------------------EGSGG 598
            |                ||..:....|.|.|.....|||:.                   |.:..
  Rat   846 HVAESGSSVAAESQLGPSDLQQIALPPGPFSGASYSVITAPPVEGRASASGPPYREEPPGEAAQA 910

  Fly   599 ITFNITIPQ--------PDGDQSQK-----------DSPNTTAPVS----VSIDMPNLDQAEDES 640
            :..|.|:.:        .||.|...           .||:|.||.:    :....|..|..|..|
  Rat   911 VVVNDTLKEAGTHYIMAADGTQLHHIELTADGSISFPSPDTLAPGTKWPLLQCGGPPRDGPEVLS 975

  Fly   641 QSQGSIDAKGESGEASSADSKSNA----APVSMPSLDDDNEAAAAEAEASEETKTASKAGQEKAK 701
            .:: :....|..|.::...:.|:|    .|.|.||       |||.:......|..|:|...:|:
  Rat   976 PTK-THHTGGSQGSSTPPPATSHALGLLVPHSPPS-------AAASSTKKFSCKVCSEAFPSRAE 1032

  Fly   702 AKAGESAKSKEAA-----------------------AAEEPQPSDEGDVVAKR------------ 731
            .::.:.|.:..||                       ::..|...::....:|.
  Rat  1033 MESHKRAHAGPAAFKCPDCPFSARQWPEVRAHMAQHSSLRPHQCNQCSFASKNKKDLRRHMLTHT 1097

  Fly   732 ------------------------------EATDTPTTESEANATTAEAGESGEGEVTASTGAEG 766
                                          :...|.|:.:.|.|.|.......|...|..|..:.
  Rat  1098 NEKPFSCHVCGQRFNRNGHLKFHIQRLHSIDGRKTGTSTARAPAQTIILNSEEETLATLHTAFQS 1162

  Fly   767 EAG--------EAAGGEHVAMELDEAMQAQVEGGQIKFIVNEN---GHLLQLDNHILTDAEGNQI 820
            ..|        :|...||:.:..::.:..|.|...|:.|..:.   .||:..||.:      ..|
  Rat  1163 NHGTLGTERLQQALSQEHIIVAQEQTVANQEEATYIQEITADGQTVQHLVTSDNQV------QYI 1221

  Fly   821 IVQDPEQIQQLL-QSVGVLQSGEGLEGETLQMMTDGSGQMVLVHGDNNEQQLIDASLLNSEGQLI 884
            |.||  .:|.|| |...|:..|..::
  Rat  1222 ISQD--GVQHLLPQEYVVVPDGHHIQ--------------------------------------- 1245

  Fly   885 IQQGQDGEEGAHVISEDGTRIPVSVSYTEDGQ----PIVQVQQQVLEAAQQAASASGGADDKEAA 945
            :|:||.    .|:..|.||      .:.::.|    |:...||.|.:|..:||:.|.    ..|.
  Rat  1246 VQEGQI----THIQYEQGT------PFLQESQIQYVPVSPSQQLVTQAQLEAAAHSA----VTAV 1296

  Fly   946 ADSAGEEVQ 954
            ||:|..:.|
  Rat  1297 ADAAMAQAQ 1305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	6/33 (18%)
		C2H2 Zn finger	268..289	CDD:275371	6/20 (30%)
		C2H2 Zn finger	297..318	CDD:275371	5/20 (25%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..399	CDD:290200	9/25 (36%)
		zf-C2H2_8	375..443	CDD:292531	19/102 (19%)
		C2H2 Zn finger	390..410	CDD:275368	4/19 (21%)
		C2H2 Zn finger	417..437	CDD:275368	5/52 (10%)
Zfp335	NP_001093956.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	199..222
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	282..398
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..442
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	732..766		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	961..1013		14/59 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100