DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and Zfp91

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_001162591.1	Gene:	Zfp91 / 246282	RGDID:	628736	Length:	568	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	79/475 - (16%)
Similarity:	140/475 - (29%)	Gaps:	135/475 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSSGAVTVTGPSQPRILKSTRMVVPGGGGGGGASAGGASAVG---------------------GV 60
            |.||   |...::|....|:|::..|...|..|:|..|:||.                     |.
  Rat    31 LRSG---VAAAAKPAETASSRVLRGGRDRGRTAAAAAAAAVSRRRKAEYPRRRRSSPSNRPPDGH 92

  Fly    61 AQQQAVNDAESGGVGIGGLATRCYICDDRCEPQTSLTDMCTTHTSTKFPNKLAQLVGEGFLVIVC 125
            ..|.|.....|...|             :..|:....:..||....|...:...::.:...:...
  Rat    93 GHQPAAAKPPSPAQG-------------KKSPRLQCIEKITTDKDPKEEKEDDSVLPQEVSITAT 144

  Fly   126 --GEDYVCSRCTNLVNYYDRLENDVERVKTNLISLLNKKYAINEDMGQEGSPPLKMQKMVGGSAN 188
              ...:..|..|::....|.......|.||..:.|:.|...|.:.:..:  .|.:.|...|.|::
  Rat   145 RPSRSWRSSSRTSISRLRDSENTRSSRSKTGSLQLVCKTEPITDQLDYD--VPEEHQSPSGISSD 207

  Fly   189 RSLEE---------------------SPSADLLRPRKLLQGNPVGQSK----------IAPGTTQ 222
            ...||                     .|..:...|:...:...|.:.|          :.....:
  Rat   208 EEEEEEEMLISEEEIPFKDDPRDETYKPHLERETPKPRRKSGKVKEEKEKKEIKVEVEVEVKEEE 272

  Fly   223 SSVQGTQTVQRK--------------------ATKIYKC--TSCDYKTSDMRLFNTH--YETCKQ 263
            :.::..:...||                    ..:..:|  ..|....:..|....|  |:...:
  Rat   273 NEIREDEEPPRKRGRRRKDDKSPRLPKRRKKPPIQYVRCEMEGCGTVLAHPRYLQHHIKYQHLLK 337

  Fly   264 QTFQC--KTCRKIFPHFGAMKQHMVRDHNTAMDNTCAMCHINFVNENSLRKHMETNHATNVLVTS 326
            :.:.|  .:|.::|.....:.:| .:.|....|..|..|...|.:.::|..|...:
  Rat   338 KKYVCPHPSCGRLFRLQKQLLRH-AKHHTDQRDYICEYCARAFKSSHNLAVHRMIH--------- 392

  Fly   327 TTTIPASAAPVAAAAAAAAAAANENLVGTSLYTCNHCQFKSTDKVVFDEHMRKHAAGKPKPFKCR 391
                                      .|.....|..|.|....|...:.||:||.|.....|.|.
  Rat   393 --------------------------TGEKPLQCEICGFTCRQKASLNWHMKKHDADSFYQFSCN 431

  Fly   392 LCSQRFETREAATVH-AKQH 410
            :|.::||.:::...| ||.|
  Rat   432 ICGKKFEKKDSVVAHKAKSH 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	5/25 (20%)
		C2H2 Zn finger	268..289	CDD:275371	4/22 (18%)
		C2H2 Zn finger	297..318	CDD:275371	5/20 (25%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..399	CDD:290200	9/25 (36%)
		zf-C2H2_8	375..443	CDD:292531	14/37 (38%)
		C2H2 Zn finger	390..410	CDD:275368	7/20 (35%)
		C2H2 Zn finger	417..437	CDD:275368
Zfp91	NP_001162591.1	zf-C2H2_8	311..388	CDD:292531	15/77 (19%)
		C2H2 Zn finger	345..364	CDD:275368	3/19 (16%)
		C2H2 Zn finger	372..392	CDD:275368	5/19 (26%)
		zf-H2C2_2	384..409	CDD:290200	6/59 (10%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	430..446	CDD:275368	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100