DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and Zfp407

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_001028513.2	Gene:	Zfp407 / 240476	MGIID:	2685179	Length:	2246	Species:	Mus musculus

Alignment Length:	1090	Identity:	216/1090 - (19%)
Similarity:	345/1090 - (31%)	Gaps:	384/1090 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 GASAVGGVAQQQAVNDAESG-------GVGIGGLATRCYICDDRCEPQTSLTDMCT---THTSTK 107
            |.:|.||...:..:.|...|       | |..|.:||.     ||:....|.|..:   .|.:.|
Mouse  1369 GLTATGGRVSELPLKDCAQGLKKKKVEG-GSFGESTRI-----RCDDCGFLADGLSGLNVHIAMK 1427

  Fly   108 FPNKLAQLVGEGFLVIVCGEDYV---------------------------------CSRCTNLVN 139
            .|.|     .:.|..::||:.:.                                 |.:||   .
Mouse  1428 HPTK-----EKHFHCLLCGKSFYTESNLHQHLASAGHMRNEQASVEELPEGGATFKCVKCT---E 1484

  Fly   140 YYDRLENDVERVKTNLISLLNK--KYAINEDMGQEGSPPLKMQKMVGGSANRSLEESPSADLLRP 202
            .:|..:|....:|.....||.:  ||.: ||..|               .||..||:
Mouse  1485 PFDSEQNLFLHIKGQHEELLREVNKYIV-EDTEQ---------------INREREEN-------- 1525

  Fly   203 RKLLQGNPVGQSKIAPGTTQSSVQGTQTVQRKATKIYKCTSCD--YKTSDMRLFNTHYET-CKQQ 264
                |||                              .|..|.  .::|:...|..|..| ...:
Mouse  1526 ----QGN------------------------------VCKYCGKMCRSSNSMAFLAHIRTHTGSK 1556

  Fly   265 TFQCKTCRKIFPHFGAMKQHMVRDHNTAMDNTCAMCHINFVNENSLRKHMETNHATNVLVTSTTT 329
            .|:||.|.......|..:.| |:.|....:..|.:|.:.||.:..|..|:...|.
Mouse  1557 PFKCKICHFATAQLGDARNH-VKRHLGMREYKCHVCGVAFVMKKHLNTHLLGKHG---------- 1610

  Fly   330 IPASAAPVAAAAAAAAAAANENLVGT---SLYTCNHCQFKSTDKVVFDEHMRKHAAGKP------ 385
                                   |||   ..:||:.|....|:|...:.||:.|...||
Mouse  1611 -----------------------VGTPKERKFTCHLCDRSFTEKWALNNHMKLHTGEKPFKCTWP 1652

  Fly   386 ----------------------KPFKCRLCSQRFETREAATVHAKQHQ-TNFFKCGTCSMTFPKR 427
                                  |.|.|.||.....||.|.|.|.:||. ...|||..|:.....:
Mouse  1653 TCHYSFLTASAMKDHYRTHTGEKSFLCDLCGFAGGTRHALTKHRRQHTGEKPFKCDECNFASTTQ 1717

  Fly   428 EMLVKHFEVH--QSP-SASTVSPKQSVSQNLNTQKLLQETIDEALSDSLPASTAAVVATTESENN 489
            ..|.:|..||  :.| .......:.:.::|:...                      :..|.....
Mouse  1718 SHLTRHKRVHTGEKPYRCPWCDYRSNCAENIRKH----------------------ILHTGKHEG 1760

  Fly   490 IRFFSCSICSL-TFIQETYYNHHMETH----RRDKKATSAGATALN-------SAATALLSDEPG 542
            ::.::|..|.. |.:...:.||..|.|    ..|.....||..:.:       ..||.:.:|.|.
Mouse  1761 VKMYNCPKCDYGTNVPVEFRNHLKEQHPDIENPDLAYLHAGIVSKSYECRLKGQGATFVETDSPF 1825

  Fly   543 EAT---------------------------------GKAG----DESGEQNAEADIESLFEKLHS 570
            .|.                                 |..|    |.|.|:.|.|.:::|
Mouse  1826 TAATLAEESPVKERSLRSSKRQAASPEQVQQVIIIQGYDGEFALDASVEETAAATLQTL------ 1884

  Fly   571 DKNESGEAPKPG--SKGGEMVITSQEGS--GGITFNITIPQPDGDQSQKDSPNTTAPVSVSIDMP 631
              ..:|:..:..  ::.|:::.|||.||  |.:.....:|:...|       .||..|.:...|.
Mouse  1885 --AMAGQVARVVHITEHGQVIATSQNGSHVGSVVPGPILPEQLAD-------GTTQVVVMGGSME 1940

  Fly   632 NLDQAEDESQSQGSIDAKGESGEASSADSKSNAAPVSMPSLDDDNEAA--AAEAEASEETKTASK 694
            :  .:.||:.|.|:...:..:.:...:.|::...|       .||.:|  |.....:|..:...:
Mouse  1941 S--HSVDEALSPGAAVIQQVTKQEVLSLSEAGVPP-------SDNSSALDALLCAVTELGEVEGR 1996

  Fly   695 AGQEKAKAKAGESAK-------SKEAAAAEEPQPSDEGDVVAKREATDT----PTTESEANATTA 748
            .|.|:   |...|.|       |:|||.|.           ||.|||:.    ...||.|:....
Mouse  1997 VGHEE---KGRPSHKDVLIQLPSQEAAQAH-----------AKAEATEAQLFQDVEESPASMEVL 2047

  Fly   749 EAGESGEGEVTASTGAEGEAGEAAGGEHVAMELDEAMQAQ-VEGGQIKFIVNENGHLLQLDNHIL 812
            .........:|:...|:....:...|.......|.|..:| ::.|..:.||||.|.:     |::
Mouse  2048 TQVVRPSTIITSQERAQVAFKKMVQGVLQFAVCDTAAASQLIKDGVTQVIVNEEGAV-----HMV 2107

  Fly   813 TDAEGNQIIVQD--------PEQIQQLLQSVGVLQSGEGLEGETLQMMTDGSGQMVLVHGDNNEQ 869
            . .||:|.|:|:        |.:...|::|          |||..|::.              .:
Mouse  2108 A-GEGSQFIMQEAETHGLRVPAEHMDLVES----------EGEISQIIV--------------TE 2147

  Fly   870 QLIDASLLNSEGQLIIQQGQDGEEGA-HVISEDGTRIPVSVSYTED----GQPIVQV--QQQVLE 927
            :|:.|.:..|....        .||| |.|.   |.:|..|.  ||    ...:::.  ..::|:
Mouse  2148 ELVQAMVRESNSSF--------PEGATHYIV---TELPPGVQ--EDTGVYSHTVIETASSPEILQ 2199

  Fly   928 AAQQAASASGGADDKEAAADSAGEEV--QVSEASSGTASTTVVATSTASS 975
            |        |.|...||...|:.|::  .|.....|:.:.||:.:...:|
Mouse  2200 A--------GAALSAEAVGSSSTEQLTSMVIYTQDGSPAATVIQSQRENS 2241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	6/24 (25%)
		C2H2 Zn finger	268..289	CDD:275371	6/20 (30%)
		C2H2 Zn finger	297..318	CDD:275371	6/20 (30%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..399	CDD:290200	10/53 (19%)
		zf-C2H2_8	375..443	CDD:292531	26/99 (26%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		C2H2 Zn finger	417..437	CDD:275368	4/19 (21%)
Zfp407	NP_001028513.2	C2H2 Zn finger	180..200	CDD:275368
		C2H2 Zn finger	209..230	CDD:275368
		C2H2 Zn finger	524..552	CDD:275371
		C2H2 Zn finger	553..575	CDD:275371
		C2H2 Zn finger	1407..1436	CDD:275371	7/33 (21%)
		C2H2 Zn finger	1437..1459	CDD:275371	2/21 (10%)
		C2H2 Zn finger	1479..1500	CDD:275371	6/23 (26%)
		C2H2 Zn finger	1530..1552	CDD:275368	5/21 (24%)
		zf-H2C2_2	1548..1569	CDD:290200	6/20 (30%)
		C2H2 Zn finger	1560..1580	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1588..1608	CDD:275368	6/19 (32%)
		COG5048	<1618..1737	CDD:227381	31/118 (26%)
		C2H2 Zn finger	1621..1641	CDD:275368	6/19 (32%)
		zf-H2C2_2	1633..1660	CDD:290200	5/26 (19%)
		C2H2 Zn finger	1649..1671	CDD:275368	0/21 (0%)
		C2H2 Zn finger	1679..1699	CDD:275368	8/19 (42%)
		zf-H2C2_2	1691..1716	CDD:290200	9/24 (38%)
		COG5048	1703..>1758	CDD:227381	11/76 (14%)
		C2H2 Zn finger	1707..1727	CDD:275368	4/19 (21%)
		zf-H2C2_2	1719..1744	CDD:290200	5/24 (21%)
		C2H2 Zn finger	1735..1752	CDD:275368	1/38 (3%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100