DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pzg and Zfp646

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_766337.2	Gene:	Zfp646 / 233905	MGIID:	3665412	Length:	1788	Species:	Mus musculus

Alignment Length:	1194	Identity:	229/1194 - (19%)
Similarity:	356/1194 - (29%)	Gaps:	411/1194 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GASAGGASAVGGVAQQQAVNDAESGGVGIGGLATRCYICDDRCEPQTSLTDMCTTHTSTKFPNKL 112
            ||..||.|:|...|...|.|..:...|....|..|.|.|:: |       .....|..:...::.
Mouse   421 GAGEGGQSSVSSTALTSAENTPKVDEVPTASLDHRPYKCNE-C-------GRAYRHRGSLVNHRH 477

  Fly   113 AQLVGEGFLVIVCGEDYVCSRCTNLVNYYDRLENDVERVKTNLISLLN------KKYAINEDMGQ 171
            :...||          |.||.|              .|...||::|.|      |....:.|.|.
Mouse   478 SHRTGE----------YQCSLC--------------PRKYPNLMALRNHVRVHCKATRRSTDPGT 518

  Fly   172 EGSP---------PLKMQKMVGGS---ANRSLEESPS----ADLLRPR------------KLLQG 208
            ||||         |:.|:....|.   |.:..||:.|    ||...|:            |.|:.
Mouse   519 EGSPSPVKKEQHDPVGMEAAFHGDEEHACKREEEATSNPSMADRTVPQVCSICGMLFEDLKSLEH 583

  Fly   209 NPVGQSKIAPGTTQSSVQGTQTVQRKATKIYKCTSC--DYKTSDMRLFNTHYETCKQQTFQCKTC 271
            :.|...:.....|.|:|..|:|        :.|..|  .|:.|. .|.| |.:|.:...|.|..|
Mouse   584 HSVTHREGEKSRTDSTVSPTRT--------FACQDCGKSYRHSG-SLIN-HRQTHQTGDFSCGAC 638

  Fly   272 RKIFPHFGAMKQHMVR------------------------------------DHNTAMD------ 294
            .|.|....|||.|:.|                                    |.:::.|
Mouse   639 AKHFHTMAAMKSHLRRHSRQWNRRRQKQDSGTGEVATLPPGGAWTLKLENDEDPDSSQDPLGESP 703

  Fly   295 --------------------NTCAM-----------------------CHINFV-------NENS 309
                                |.|.:                       |.::.:       ||..
Mouse   704 CETEDNLERDGDCLQAGSRGNECVLKREEACFLGDKEGTEEGLEEREACFLDDLGTPGDECNETG 768

  Fly   310 L---RKHMETNHATNVLVTSTTTIPASAAPVAAAAAAAAAAANENLVGTSLYTCNHC--QFKSTD 369
            .   ...|:::....:..:.:::.||.|..|..|||.              :||:.|  .|
Mouse   769 FCGGLPGMDSDRKRGICHSDSSSHPADADTVWKAAAT--------------HTCSDCGDSF---- 815

  Fly   370 KVVFDEHMRKHAAG--------KPKPFKCRLCSQRFETREAATVHAKQHQ------TNFFKCGTC 420
                     .||||        .|..::|.||.:.|::..|...|.:.|:      ...|.|..|
Mouse   816 ---------SHAAGLLSHRSCHPPGIYQCSLCPKEFDSLPALRSHFQTHRPGEVASAQPFLCCLC 871

  Fly   421 SMTFPKREMLVKHFEVHQSPSASTVSPKQSVSQNLNTQKLLQETIDEALSDSLPASTAAVVATTE 485
            .|.||.|....:|.......||.|...::..          :.|.:.|.:.|.|...:......:
Mouse   872 GMIFPGRTGYRRHLRQAHGASAMTEGSEEEE----------EGTAETASTHSPPLQLSEAELLNQ 926

  Fly   486 SENNIRFFS-------CSICSLTFIQETYYNHHMETHRRDKKATSAGATALNSAATALLSDEPGE 543
            .:..:....       |..|..|      |:......|..:..:|:..|          .:.|..
Mouse   927 LQREVEALDGAGYGHICGCCGQT------YDDLGSLERHHQSQSSSNRT----------ENVPSH 975

  Fly   544 ATGKAGDESGEQNAEADIESLFEKLHSDKNESGEAPKPGSKGGEMVITSQEGSGGI--------- 599
            ..| |||.:              ::.:|....|.......:||:  |.|:||.||.
Mouse   976 LEG-AGDAT--------------EMVADHGFEGTVTSVSEEGGD--IKSEEGVGGTVADSLCMQA 1023

  Fly   600 --TFNITIPQP-DGDQSQK---------------DSPNTTAPVSVSIDMPNL----DQAEDESQS 642
              :|..:.|:| ..:|..|               .:.:...|| .|...|||    :...:..:.
Mouse  1024 GESFLESHPRPFQCNQCGKTYRHGGSLVNHRKIHQTGDFICPV-CSRCYPNLAAYRNHLRNHPRC 1087

  Fly   643 QGSIDAKGESGEASSADSKSNAAPVSMPSLDDDNEAAAAEAEASEETKTASKAGQEKAKAKAGES 707
            :||....|...||.......|||        :..:..|...:..||.|.      |..:..||..
Mouse  1088 KGSEPQMGPISEAGGCSEPQNAA--------EAGQEQAVIGQLQEELKV------EPLEELAGVK 1138

  Fly   708 AKSKEAAAAEEPQPSDEGDVVAKREAT-DTPTTESEANATTAEAGESGEGEVTASTGAEGEAGEA 771
            .:..|..|.:|.:...|.:...:.|.| :.|.:......|...||.......:..||..|....:
Mouse  1139 EEVWEGTAVKEEELEQELETGCQTEVTSERPFSCEVCGRTYKHAGSLINHRQSHQTGHFGCQACS 1203

  Fly   772 AGGEHVAMELDEAMQAQVEGGQIKFIVNENGHLL----QLDNHILTDAE-----GNQIIVQDPE- 826
            .|..:: |.|....:...:..|  |..:|.|...    ||.||....||     |.|.:.::..
Mouse  1204 KGFSNL-MSLKNHRRIHADPRQ--FRCSECGKAFRLRKQLANHQRVHAERRRSRGTQKLTREDRP 1265

  Fly   827 ----QIQQLLQSVG---------------------------VLQSGEGLEGETLQMMTDG----- 855
                |..:..:..|                           .|:..:.:..::.|....|
Mouse  1266 FRCGQCGRTYRHAGSLMNHQCNPEASRYSCPFCFKTYSNRTALKDHQRVHSDSQQRRQSGCPQRA 1330

  Fly   856 ------------SGQMVLVHGDNNEQQLIDASLLNSEGQLIIQQGQDGEEGAHVISEDGTRIPVS 908
                        |||..|   :.:.|:..|..|..:.|    |.||...||:....:|.     .
Mouse  1331 AAVRCTLCGCGFSGQGSL---EQHLQEHEDTKLEVASG----QGGQHATEGSEENLDDW-----G 1383

  Fly   909 VSYTEDGQPIVQVQQQVLEAAQQAASASGGADDKEAAADSAGEEVQVSEASSGTASTTVVATSTA 973
            :....||..::||:.:.......:.|.|..|                  .|.||.||..|.....
Mouse  1384 LEGRSDGTEVLQVEHETKRPGGHSQSPSSPA------------------CSGGTESTQQVGKVDG 1430

  Fly   974 SSTGGPSG-----GSFFALEEFTE 992
            |.  |..|     |::...::.|:
Mouse  1431 SQ--GDRGQMNHNGAWVLQDQLTK 1452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	8/23 (35%)
		C2H2 Zn finger	268..289	CDD:275371	9/56 (16%)
		C2H2 Zn finger	297..318	CDD:275371	5/53 (9%)
		C2H2 Zn finger	360..380	CDD:275368	3/21 (14%)
		zf-H2C2_2	373..399	CDD:290200	9/33 (27%)
		zf-C2H2_8	375..443	CDD:292531	21/81 (26%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..437	CDD:275368	7/19 (37%)
Zfp646	NP_766337.2	C2H2 Zn finger	10..31	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..48
		C2H2 Zn finger	69..89	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..196
		C2H2 Zn finger	233..253	CDD:275368
		C2H2 Zn finger	260..280	CDD:275368
		C2H2 Zn finger	288..308	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..360
		C2H2 Zn finger	368..388	CDD:275368
		C2H2 Zn finger	395..415	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..449		10/27 (37%)
		C2H2 Zn finger	459..479	CDD:275368	3/27 (11%)
		C2H2 Zn finger	486..506	CDD:275368	8/33 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..531		6/21 (29%)
		C2H2 Zn finger	568..588	CDD:275368	3/19 (16%)
		C2H2 Zn finger	608..628	CDD:275368	7/21 (33%)
		C2H2 Zn finger	635..655	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..712		4/60 (7%)
		C2H2 Zn finger	808..828	CDD:275368	7/32 (22%)
		C2H2 Zn finger	835..855	CDD:275368	6/19 (32%)
		C2H2 Zn finger	868..886	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..916		6/36 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..976		4/29 (14%)
		C2H2 Zn finger	1037..1057	CDD:275368	2/19 (11%)
		C2H2 Zn finger	1064..1084	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1172..1192	CDD:275368	3/19 (16%)
		C2H2 Zn finger	1199..1219	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1227..1247	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1268..1285	CDD:275368	2/16 (13%)
		C2H2 Zn finger	1295..1315	CDD:275368	1/19 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1351..1386		10/43 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1398..1439		12/60 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1455..1489
		C2H2 Zn finger	1500..1518	CDD:275368
		C2H2 Zn finger	1526..1544	CDD:275368
		C2H2 Zn finger	1552..1572	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1629
		C2H2 Zn finger	1642..1662	CDD:275368
		C2H2 Zn finger	1669..1689	CDD:275368
		zf-H2C2_2	1681..1706	CDD:372612
		C2H2 Zn finger	1697..1717	CDD:275368
		C2H2 Zn finger	1726..1746	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1744..1788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100