DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and Zfp160

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_663458.2	Gene:	Zfp160 / 224585	MGIID:	108187	Length:	650	Species:	Mus musculus

Alignment Length:	630	Identity:	134/630 - (21%)
Similarity:	207/630 - (32%)	Gaps:	140/630 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 FNNLLSSGAVTVTGPS-----------QPRILKSTRMVVPGGGGGGGASAGGASAVGGVAQQQAV 66
            ::||||.|   ||.|:           .|..::|..:......|.....|..|..:.|
Mouse    41 YSNLLSLG---VTLPNLNAMSKLEQYKGPWTVESEAIRTRKSNGKEYIRAMSAENING------- 95

  Fly    67 NDAESGGVGIGGLATRCYICDDRCEPQTSLTDMCTTHTSTKFPNKLAQLVGEGFLVIVCGEDYVC 131
            |:|:|...|...|::...:......|.....|:   ::|.:.         :|....:.|:.|.|
Mouse    96 NEAKSISSGSSILSSDKILASGDKAPVVHEYDV---YSSLRI---------KGQKATIKGKPYQC 148

  Fly   132 SRCTNLVNY-----YDRLENDVERVKTNL---ISLLNKKYAINEDMGQEGSPPLKMQKMVGGSAN 188
            ..|..:.:|     |.|..:..|::...|   .:...:.|.:..:....|:.|.|..:.  |..
Mouse   149 KECDKVFSYTSSLAYHRQIHTGEKLYKCLECGKAFFRRSYLLVHERHHTGAKPYKCNEC--GKV- 210

  Fly   189 RSLEESPSADLLRPRKLLQG------NPVGQSKIAPGTTQSSVQGTQT---VQRKATKIYKCTSC 244
                .|.::.|...|::..|      |..|::        .||:...|   |.....|.|||..|
Mouse   211 ----FSQNSHLKSHRRIHTGEKPFKCNHCGKA--------FSVRSNLTHHQVIHTGDKPYKCNEC 263

  Fly   245 DYKTSDMRLFNTHYET-CKQQTFQCKTCRKIFPHFGAMKQHMVRDHNTAMDNTCAMCHINFVNEN 308
            ....|.......|..| ..::.::|..|.|:|.....:..|.. .|.......|:.|...|...:
Mouse   264 GKVFSQTSSLTIHRRTHTGEKPYRCNECGKVFSSHSNLNTHQA-IHTGEKPYKCSECGKVFTQNS 327

  Fly   309 SLRKHM------------ETNHATNVLVTSTT--TIPASAAPVAAAAAAAAAAANENLV------ 353
            .|..|.            |...|.:|..:.||  .|.....|............|.:|.
Mouse   328 HLANHWRIHTGEKPYKCNECGKAFSVYSSLTTHQAIHTGEKPYKCNECGKVFTQNSHLASHRGVH 392

  Fly   354 -GTSLYTCNHC--QFKSTDKVVFDEHMRKHAAGKPKPFKCRLCSQRFETREAATVHAKQHQ-TNF 414
             |...|.|..|  .|..|..:.  .|.|.|..  .||:||..|.:.|..|.:...|...|. ...
Mouse   393 SGEKPYKCEECGKLFSQTSNLA--RHWRVHTG--EKPYKCSECGKAFSVRSSLIAHQVIHTGEKP 453

  Fly   415 FKCGTCSMTFPKREMLVKHFEVH--QSPSASTVSPKQSVS-QNLNTQKLLQETIDEALSDSLPAS 476
            :||..|...|.:...|..|..:|  :.|.......|...| .||||.:
Mouse   454 YKCTECGKVFSQTSSLSIHQRIHTGEKPYRCNECGKAFNSHSNLNTHQ----------------- 501

  Fly   477 TAAVVATTESENNIRFFSCSICSLTFIQETYYNHHMETHRRDK--KATSAG-ATALNSAATALLS 538
               |:.|.:..     :.|..|...|.|.::..:|..||..:|  |....| |.::.|:.|...:
Mouse   502 ---VIHTGQKP-----YKCMQCGKVFTQNSHLANHQRTHTGEKPYKCNECGKAFSVYSSLTTHQA 558

  Fly   539 DEPGEATGKAGDESGE---QNAEADIESLFEKLHSD-KNESGEAP 579
            ...||...|. :|.|:   ||:.         |.|. :..:||.|
Mouse   559 IHTGEKPYKC-NECGKVFTQNSH---------LASHRRTHTGEKP 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	5/22 (23%)
		C2H2 Zn finger	268..289	CDD:275371	5/20 (25%)
		C2H2 Zn finger	297..318	CDD:275371	6/32 (19%)
		C2H2 Zn finger	360..380	CDD:275368	6/21 (29%)
		zf-H2C2_2	373..399	CDD:290200	9/25 (36%)
		zf-C2H2_8	375..443	CDD:292531	20/70 (29%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
Zfp160	NP_663458.2	KRAB	8..68	CDD:214630	9/29 (31%)
		KRAB	8..47	CDD:279668	3/5 (60%)
		C2H2 Zn finger	148..168	CDD:275368	5/19 (26%)
		C2H2 Zn finger	176..196	CDD:275368	2/19 (11%)
		zf-H2C2_2	188..213	CDD:290200	5/31 (16%)
		COG5048	200..635	CDD:227381	100/449 (22%)
		zf-C2H2	202..224	CDD:278523	5/28 (18%)
		C2H2 Zn finger	204..224	CDD:275368	4/26 (15%)
		zf-H2C2_2	216..240	CDD:290200	5/31 (16%)
		C2H2 Zn finger	232..252	CDD:275368	6/27 (22%)
		zf-H2C2_2	244..269	CDD:290200	7/24 (29%)
		C2H2 Zn finger	260..280	CDD:275368	4/19 (21%)
		zf-H2C2_2	272..297	CDD:290200	6/24 (25%)
		C2H2 Zn finger	288..308	CDD:275368	5/20 (25%)
		zf-H2C2_2	300..325	CDD:290200	5/25 (20%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		C2H2 Zn finger	344..364	CDD:275368	5/19 (26%)
		zf-H2C2_2	356..381	CDD:290200	4/24 (17%)
		C2H2 Zn finger	372..392	CDD:275368	2/19 (11%)
		zf-H2C2_2	384..409	CDD:290200	6/24 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/21 (29%)
		zf-H2C2_2	412..436	CDD:290200	8/27 (30%)
		C2H2 Zn finger	428..448	CDD:275368	5/19 (26%)
		zf-H2C2_2	440..465	CDD:290200	6/24 (25%)
		C2H2 Zn finger	456..476	CDD:275368	5/19 (26%)
		zf-H2C2_2	468..493	CDD:290200	5/24 (21%)
		C2H2 Zn finger	484..504	CDD:275368	7/39 (18%)
		zf-H2C2_2	496..521	CDD:290200	9/49 (18%)
		C2H2 Zn finger	512..532	CDD:275368	5/19 (26%)
		zf-H2C2_2	524..548	CDD:290200	7/23 (30%)
		C2H2 Zn finger	540..560	CDD:275368	4/19 (21%)
		zf-H2C2_2	552..577	CDD:290200	6/25 (24%)
		C2H2 Zn finger	568..588	CDD:275368	6/29 (21%)
		zf-H2C2_2	580..604	CDD:290200	5/23 (22%)
		C2H2 Zn finger	596..616	CDD:275368
		zf-H2C2_2	608..633	CDD:290200
		C2H2 Zn finger	624..644	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832275
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930