DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and AgaP_AGAP003961

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	XP_318413.5	Gene:	AgaP_AGAP003961 / 1278782	VectorBaseID:	AGAP003961	Length:	1189	Species:	Anopheles gambiae

Alignment Length:	614	Identity:	113/614 - (18%)
Similarity:	188/614 - (30%)	Gaps:	232/614 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 NNLLSSGAVTVTGPSQPRILKSTRMVVPGGGGGGGASAGGASAVGGVAQQQAVNDAESGGVGIGG 78
            ||  |:|:.|....|.  :||  ||::.|.|..|.|.          |:|||
Mosquito   320 NN--STGSCTSASTSS--LLK--RMLLDGSGTAGSAP----------AEQQA------------- 355

  Fly    79 LATRCYICDDRCEPQTSLTDM-----------CTTH----------TSTKFPNKLAQLVGEGFLV 122
                        .|.||::.:           .:||          ::|..|:...|...:.
Mosquito   356 ------------PPPTSVSPLEGPSGQPSHRSTSTHHLRTTKHEPPSATNTPSPPVQRAKDD--- 405

  Fly   123 IVCGEDYVCSRCTNLVNYYDRLENDVERVKTNLISLLNKKYAINEDMGQEGSPPLKMQKMVGGSA 187
            :...|..:.|:..:::..: |...|.|...|...|:        .|...|..||...::    |:
Mosquito   406 VPTNETPLASQLRSILLQH-RAPPDWEGTTTRTASM--------SDASPEQHPPSAQER----SS 457

  Fly   188 N-------------RSL----------EESPSADL-----------LRPRKLLQGNPVGQSKIAP 218
            |             |||          |..|..|.           ||.|:..|..|..|.:...
Mosquito   458 NATSAGEKPEVSYVRSLFLRNDSDSESEPPPVEDQREMLLYAMFHELRTRQQQQQQPQHQHQQQA 522

  Fly   219 GTTQSSVQGTQTVQRKATKIYKCTSCDYKTSDMRLFNTHYETCKQQTFQCKTCRKIFPHFGAMKQ 283
            |.:..|...:..:.:           ||:...:|         ::.|...::
Mosquito   523 GFSSDSDDDSDDLPQ-----------DYRLPSVR---------RRSTDSVES------------- 554

  Fly   284 HMVRDHNTAMDNTCAMCHINFVNENSLRKHMETN------HATNVLVTS-----TTTIPA-SAAP 336
               |.....|:..|.:|..:|..:..|..||.|:      .|....::|     |.::|| |.|.
Mosquito   555 ---RPKRRRMEYPCLLCGRSFAGKTRLVLHMRTHMMLDGGGADGSTLSSGGGAATISLPAVSPAA 616

  Fly   337 VAAA--------AAAAAAAANENLVGTSL------------------------------------ 357
            :.||        .:...|:..|::.|..|
Mosquito   617 IVAAGGGVLLPNGSGGGASDVEDIAGRLLNAQQQQHHHHHHRHEDAGGFGESSVGNEDEIDALER 681

  Fly   358 --YTCNHCQFKSTDKVVFDEHM------RKHAAGKPK-----PFKCRLCSQRFETREAATVHAKQ 409
              |.|..|.....:.....||:      |..:.|:.:     ...|.:|.:.|.::.|...|.:.
Mosquito   682 RSYACYICGADQNNLAQLKEHLLAAHQDRIRSRGRTRERQKASIACEICQRSFRSQFAYGEHMRT 746

  Fly   410 HQ-TNFFKCGTCSMTFPKREMLVKH-FEVHQSPSASTVSPKQSVSQNLNTQKLLQETIDEALSDS 472
            |. ...|.|..|...||:|..|:.| :.||:....:..| |...::|.:    :.........|.
Mosquito   747 HTGERPFPCDQCDKRFPRRFQLLGHLYNVHKQSWVADES-KAKFAKNFS----ICHDYSACFIDR 806

  Fly   473 --LPASTAAVVATTESENNIRFFSCSICS 499
              |||....      :.|:.:.|.|.:|:
Mosquito   807 FFLPARPCI------ANNSAQDFFCRLCA 829

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	3/21 (14%)
		C2H2 Zn finger	268..289	CDD:275371	1/20 (5%)
		C2H2 Zn finger	297..318	CDD:275371	7/26 (27%)
		C2H2 Zn finger	360..380	CDD:275368	5/25 (20%)
		zf-H2C2_2	373..399	CDD:290200	7/36 (19%)
		zf-C2H2_8	375..443	CDD:292531	20/80 (25%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	417..437	CDD:275368	7/20 (35%)
AgaP_AGAP003961	XP_318413.5	zf-AD	16..109	CDD:214871
		zf-C2HE	<666..704	CDD:292895	5/37 (14%)
		C2H2 Zn finger	686..707	CDD:275368	4/20 (20%)
		C2H2 Zn finger	727..747	CDD:275368	5/19 (26%)
		zf-H2C2_2	742..762	CDD:290200	5/19 (26%)
		C2H2 Zn finger	755..772	CDD:275368	6/16 (38%)
		zf-AD	824..899	CDD:214871	2/6 (33%)
		C2H2 Zn finger	1088..1109	CDD:275368
		C2H2 Zn finger	1117..1142	CDD:275368
		C2H2 Zn finger	1154..1175	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100