DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pzg and LOC100365363

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	XP_006228060.2	Gene:	LOC100365363 / 100365363	RGDID:	2319215	Length:	670	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	116/531 - (21%)
Similarity:	176/531 - (33%)	Gaps:	115/531 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 AQLVGEGFLVIVCGEDYVCSRCTNLVNYY------------DRLENDVERVKTNLISLLNKKYAI 165
            :.|:.:|....:..:.|.|:.|..:..|.            ::|...||..|    :...:.|.:
  Rat   130 SSLLMKGQKAAIKEKPYQCNECDKVFRYTSSLAYHRQIHTGEKLYKCVECGK----AFFRRSYLL 190

  Fly   166 NEDMGQEGSPPLKMQKMVGGSANRSLEESPSADLLRPRKLLQG------NPVGQSKIAPGTTQSS 224
            ..:....|:.|.|..:.  |..     .|.::.|...|::..|      |..|::        .|
  Rat   191 VHERHHSGAKPYKCNEC--GKV-----FSQNSHLKSHRRIHTGEKPYKCNDCGKA--------FS 240

  Fly   225 VQGTQT---VQRKATKIYKCTSCDYKTSDMRLFNTHYET-CKQQTFQCKTCRKIFPHFGAMKQHM 285
            |:...|   |.....|.|||..|....|.......|..| ..::.::|..|.|:|.....:..|.
  Rat   241 VRSNLTHHLVIHTGDKPYKCNECGKVFSQTSSLTIHRRTHTGEKPYRCNECGKVFSSHSNLNTHQ 305

  Fly   286 VRDHNTAMDNTCAMCHINFVNENSLRKHMETN------------HATNVLVTSTT--TIPASAAP 336
            . .|.......|:.|...|...:.|..|..|:            .|.:|..:.||  .|.....|
  Rat   306 A-IHTGEKPYKCSECGKVFTQNSHLANHWRTHTGEKPYKCNECGKAFSVYSSLTTHLAIHTGEKP 369

  Fly   337 VAAAAAAAAAAANENLV-------GTSLYTCNHC--QFKSTDKVVFDEHMRKHAAGKPKPFKCRL 392
            ............|.:|.       |...|.|..|  .|..|..:.  .|.|.|..  .||:||..
  Rat   370 YKCEECGKVFTQNSHLANHRGIHSGEKPYKCEECGKHFNQTSNLA--RHWRVHTG--EKPYKCSE 430

  Fly   393 CSQRFETREAATVHAKQHQ-TNFFKCGTCSMTFPKREMLVKHFEVH--QSPSASTVSPKQSVS-Q 453
            |.:.|..|.:.|.|...|. ...:||..|...|.:...|..|..:|  :.|.......|...| .
  Rat   431 CGKAFSVRSSLTSHQVIHTGEKPYKCAECGKVFSQTSSLSIHQRIHTGEKPYRCNECGKAFNSHS 495

  Fly   454 NLNTQKLLQETIDEALSDSLPASTAAVVATTESENNIRFFSCSICSLTFIQETYYNHHMETHRRD 518
            ||||.:                    |:.|.:..     :.|..|...|.|.::..:|..||..:
  Rat   496 NLNTHQ--------------------VIHTGQKP-----YKCLECGKVFTQNSHLANHHRTHTGE 535

  Fly   519 K--KATSAG-ATALNSAATALLSDEPGEATGKAGDESGE---QNAEADIESLFEKLHSD-KNESG 576
            |  |....| |.::.|:.|...:...||...|. :|.|:   ||:.         |.|. :..:|
  Rat   536 KPYKCNECGKAFSVYSSLTTHQAIHTGEKPFKC-NECGKVFTQNSH---------LASHRRTHTG 590

  Fly   577 EAPKPGSKGGE 587
            |.|...||.|:
  Rat   591 EKPYKCSKCGK 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	5/22 (23%)
		C2H2 Zn finger	268..289	CDD:275371	5/20 (25%)
		C2H2 Zn finger	297..318	CDD:275371	6/32 (19%)
		C2H2 Zn finger	360..380	CDD:275368	6/21 (29%)
		zf-H2C2_2	373..399	CDD:290200	9/25 (36%)
		zf-C2H2_8	375..443	CDD:292531	21/70 (30%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		C2H2 Zn finger	417..437	CDD:275368	5/19 (26%)
LOC100365363	XP_006228060.2	KRAB	8..68	CDD:214630
		SFP1	<143..221	CDD:227516	15/88 (17%)
		C2H2 Zn finger	148..168	CDD:275368	3/19 (16%)
		C2H2 Zn finger	176..196	CDD:275368	4/23 (17%)
		COG5048	200..575	CDD:227381	94/420 (22%)
		C2H2 Zn finger	204..224	CDD:275368	4/26 (15%)
		C2H2 Zn finger	232..252	CDD:275368	6/27 (22%)
		C2H2 Zn finger	260..280	CDD:275368	4/19 (21%)
		C2H2 Zn finger	288..308	CDD:275368	5/20 (25%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		C2H2 Zn finger	344..364	CDD:275368	4/19 (21%)
		C2H2 Zn finger	372..392	CDD:275368	2/19 (11%)
		C2H2 Zn finger	400..420	CDD:275368	6/21 (29%)
		C2H2 Zn finger	428..448	CDD:275368	6/19 (32%)
		C2H2 Zn finger	456..476	CDD:275368	5/19 (26%)
		C2H2 Zn finger	484..504	CDD:275368	7/39 (18%)
		C2H2 Zn finger	512..532	CDD:275368	5/19 (26%)
		C2H2 Zn finger	540..560	CDD:275368	4/19 (21%)
		C2H2 Zn finger	568..588	CDD:275368	6/29 (21%)
		zf-H2C2_2	580..604	CDD:404364	8/31 (26%)
		C2H2 Zn finger	596..615	CDD:275368	3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335937
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930