DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pzg and zfp64

DIOPT Version :9

Sequence 1:	NP_001262143.1	Gene:	pzg / 40351	FlyBaseID:	FBgn0259785	Length:	996	Species:	Drosophila melanogaster
Sequence 2:	NP_001373446.1	Gene:	zfp64 / 100003733	ZFINID:	ZDB-GENE-031118-80	Length:	642	Species:	Danio rerio

Alignment Length:	842	Identity:	169/842 - (20%)
Similarity:	274/842 - (32%)	Gaps:	243/842 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 LAQLVGEG---FLVIVCGEDYVCSRC----TNLVNYYDRLENDVERVKTNLISLLNKKYAINEDM 169
            :|...|||   .||.|..:.::|..|    .|:..::...:|..:...|: ||:.|
Zfish     1 MATFNGEGINHLLVEVSPDIHICGFCKQQYNNVELFFAHKQNCCQIPSTH-ISVRN--------- 55

  Fly   170 GQEGSPPLKMQKMVGGSANRSLEESPSADLLRPRKLL---QGNPVGQSKIAPGTTQSSVQGTQTV 231
                           ..|:.||:...|    :.:|.|   |.||  ..|:.|..||
Zfish    56 ---------------AGASESLQTCVS----KVKKTLTKAQKNP--SKKLKPALTQ--------- 90

  Fly   232 QRKATKIYKCT--SCDYKT----SDM-RLFNTHYETCKQQTFQCKTCRKIFPHFGAMKQHMVRDH 289
                 |.:.||  .|.:||    .|| |...||   ..::.|:|:.|.|.|.....:..|. |.|
Zfish    91 -----KRHICTFSGCTFKTQYGQKDMERHILTH---TGERPFECELCHKRFSRRDKLNLHS-RLH 146

  Fly   290 NTAMDNTCAMCHINFVNENSLRKHMETNHATNVLVTSTTTIPASAAPVAAAAAAAAAAANENLVG 354
            .....:.|..|.....:.:||:||:..::       ..........|.|:..::.......:..|
Zfish   147 TGEKPHKCKYCTYAAADSSSLKKHLRIHY-------DERPFKCQICPYASRNSSQLTVHLRSHTG 204

  Fly   355 TSLYTCNHCQFKSTDKVVFDEHMRKHAAGKPKPFKCRLCSQR--FETREAATVHAKQHQTNFFKC 417
            .:.:.||.|..|.........|.|.|:.  .||:||.||..|  .:....:.||.|...::.|.|
Zfish   205 DAPFQCNQCDAKFKINSDLKRHSRVHSG--EKPYKCDLCDYRCAMKANLKSHVHLKHSASDSFHC 267

  Fly   418 GTCSMTFPKREMLVKHFEVHQSPSASTVSPKQSVSQNLNTQKLLQETIDEALSDSLPASTAAVVA 482
            ..|......:..|..|...|| |:......:.|.|.:......:.|.:.   ||..|
Zfish   268 SKCDFQCSTKAALRHHSRQHQ-PAQPLQCSECSYSCSSKGALKIHERVH---SDERP-------- 320

  Fly   483 TTESENNIRFFSCSICSLTFIQETYYNHHMETHRRDKKATSAGATALNSAATALLSDEPGEATGK 547
                      |.|.:||....|.:    ::..|.|...|                 |:| :...|
Zfish   321 ----------FKCDLCSFASKQRS----NLLIHTRKCHA-----------------DKP-DRLSK 353

  Fly   548 AGDESGEQNAEADIESLFEKLHSDKNESGEAPK----PGSKGGEMVITSQEGSGGITFNITIPQP 608
            :|..||  |.| |:.......:..|.|:..|.:    ..|...|..:.|.:....   |||
Zfish   354 SGRISG--NGE-DLTKPISSRYRAKLEATRAYRCDLCEASFVREDSLRSHKRQHN---NIT---- 408

  Fly   609 DGDQSQKDSPNTTAPVSVSIDMPNLDQAEDESQSQGS--------IDAKGESGEASSAD-SKSNA 664
                 |:.|.|.|:..|....:.|:.:|...::|..:        |.|.....|||... |||.|
Zfish   409 -----QQQSHNQTSQTSTKQPVQNIPEASIATESPSTYNTTHLKIIVAPSLGSEASFVQTSKSGA 468

  Fly   665 APVSMPSLDDDNEAAAAEAEASEETKTASKAGQEKAKAKAGESAKSKEAAAAEEPQPSDEGDVVA 729
            ..:.    .||::......             .:.....|.|.|...:.....:..||
Zfish   469 VLLG----SDDHDVLLNPV-------------LQHVSMLAPEGALEHQTVLLAQISPS------- 509

  Fly   730 KREATDTPTTESEANATTAEAGESGEGEVTASTGAEGEAGEAAGGEHVAMELDEAMQAQVEGGQI 794
              |.....::::...:.:|.|.|:....:|:.:..|              .|.:.:|   |||
Zfish   510 --ETVSQSSSQNFIASCSASASEATHTFITSCSDLE--------------SLHKLIQ---EGG-- 553

  Fly   795 KFIVNENGHLLQLDNHILTDAEGNQIIVQDPEQIQQLLQSVGVLQSGEGLEGETLQMMTDGSGQM 859
                          ..:....|.|.:|....|.:              .::|.:.|.|:..:|.
Zfish   554 --------------TEVTVVTEANPMIASTKESL--------------NIDGSSSQDMSRHAGN- 589

  Fly   860 VLVHGDNNEQQLIDASLLNSEGQLIIQ--------QGQDGEE---GAHVISEDGTRIPVSVS 910
            :|.|         ||..:...|.:::|        |.|:.::   ..|.|..|...:.:|.|
Zfish   590 ILPH---------DALDIGPPGTILVQSLPLSISTQHQEDDKFHLSPHHIFSDSNTVDISDS 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pzg	NP_001262143.1	C2H2 Zn finger	241..263	CDD:275371	10/28 (36%)
		C2H2 Zn finger	268..289	CDD:275371	6/20 (30%)
		C2H2 Zn finger	297..318	CDD:275371	6/20 (30%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		zf-H2C2_2	373..399	CDD:290200	10/27 (37%)
		zf-C2H2_8	375..443	CDD:292531	21/69 (30%)
		C2H2 Zn finger	390..410	CDD:275368	7/21 (33%)
		C2H2 Zn finger	417..437	CDD:275368	4/19 (21%)
zfp64	NP_001373446.1	C2H2 Zn finger	95..118	CDD:275368	8/22 (36%)
		zf-H2C2_2	110..135	CDD:404364	10/27 (37%)
		C2H2 Zn finger	126..146	CDD:275368	6/20 (30%)
		zf-H2C2_2	139..162	CDD:404364	5/23 (22%)
		C2H2 Zn finger	154..174	CDD:275368	6/19 (32%)
		SFP1	<176..260	CDD:227516	20/85 (24%)
		C2H2 Zn finger	182..202	CDD:275368	2/19 (11%)
		C2H2 Zn finger	210..230	CDD:275368	6/19 (32%)
		zf-H2C2_2	222..246	CDD:404364	10/25 (40%)
		C2H2 Zn finger	238..257	CDD:275368	5/18 (28%)
		C2H2 Zn finger	323..341	CDD:275368	5/21 (24%)
		C2H2 Zn finger	384..404	CDD:275368	3/19 (16%)
		SP1-4_N	<408..>605	CDD:425404	49/288 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24403
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100