DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRP1 and mgl

DIOPT Version :10

Sequence 1:NP_002323.2 Gene:LRP1 / 4035 HGNCID:6692 Length:4544 Species:Homo sapiens
Sequence 2:NP_572563.3 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster


Alignment Length:4459 Identity:1631/4459 - (36%)
Similarity:2323/4459 - (52%) Gaps:472/4459 - (10%)


- Green bases have known domain annotations that are detailed below.


Human    27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNC-----LGTELCV 86
            |...||.|.:.: ||...:.|||..||.|.||||     ...|..|..|:|.|     .||..|:
  Fly   332 CHHAQFRCTNAL-CIPYNFHCDGYHDCADKSDEA-----NCTAIACPDNKHLCPRGGASGTPKCI 390

Human    87 PMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDF 151
            ..|:||:|.:||.|||||..:|.  ..:|..|.|:..|.|:|.|..|||.....|..|.:||.|.
  Fly   391 LKSQLCDGKRDCEDGSDEETNCS--IASCPALSCEFKCGPSLTGGVCYCKPGQSLAPDNRTCVDL 453

Human   152 DECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSG 216
            |||:.:|.|.||||||.||:.|.|.:||.|..|:: |.|   |......|:.|:.:.|:.....|
  Fly   454 DECAEWGHCDQLCTNTLGSYTCQCAQGYTLINDSK-CIA---PDANNLQLIFAHDRAIMRMLPHG 514

Human   217 AQVSTITPTSTRQTTA---MDFSYANETVCWVHVGDSAAQT-----QLKCA-----RMPGLKGFV 268
            ::     |......||   :.|.||..|:.|..:.....|:     |.|..     .:||....|
  Fly   515 SE-----PKILANATAAAGVTFHYARNTLYWSDIKTRKVQSLPLDAQNKAVSPFDQTLPGTWAPV 574

Human   269 DEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPA 333
                           .:|:||:....|..|.:..:|.|...:|.....:|...|.:|..:||||.
  Fly   575 ---------------ALAVDWVGDKIYVADLVGQKIDVFELSGQWHAVVLGSNLTSPADLALDPT 624

Human   334 MGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEG 398
            .|.:|..|.||   |.|..|||.:...:|........|:|:|::|:.|:|.|:.|||||.|||||
  Fly   625 AGLMFVADGGQ---VLRAHMDGTHARSIVSEAAYKASGVTVDIISKRVFWCDSLLDYIESVDYEG 686

Human   399 KGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNS-TEYQVV-----TRVD 457
            ..|..:::|..:.....|.:|||.:|.|::      .|..::.|::|.. |..||.     .|..
  Fly   687 AHRVMVLRGQQVPSPSRLALFENRIYWTDA------TKQGIMSVDKFEGPTSIQVTYKAKDIREP 745

Human   458 KGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKART-----CRCRSGFSLGSDGK 517
            ||  :...|...|||| |:.|.|:.    |||:.:|::.....|.|     |.|.:|:.|.:|.|
  Fly   746 KG--IIAVHALSQPRV-SNPCGNNN----GGCNHMCIVTAVKGAPTGLGFRCACSTGYQLETDLK 803

Human   518 SCKKPEHELFLVYGKGRPGIIRGMDMGAKVP--DEHMIPIENLMNPRA----LDFHAETGFIYFA 576
            .| ||..| ||:|.:.|  .|:|..:...:.  .:.::|:   ::.||    |||.|...|||::
  Fly   804 LC-KPVSE-FLMYSQQR--FIKGKVLEPVIEGFSDAIMPV---VSRRARFVGLDFDARDEFIYYS 861

Human   577 DTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKT 641
            |....:|.|...:||.||.:|......|||:||||...|||:. |..|.|::|........ |:|
  Fly   862 DVLQDVIYRVHRNGTGREIVLASQNEGVEGLAVDWASKNLYYI-DSRKGTLNVLSTRNVTH-RRT 924

Human   642 LIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSL 706
            |:: .:..||||||.|..|::::::|:      |...:.||..|||...:| .:.|:.||||||:
  Fly   925 LLK-NLKRPRAIVVHPNRGFIFFSEWD------RPANITRANTDGSGLLVF-KNVTLGWPNGLSI 981

Human   707 DIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERG 771
            |....|:||.||..|.::...|:|||.|.| ....:.|.|.:..|.::::.|::|..::.||.: 
  Fly   982 DFKEDRVYWCDALLDHVQHANLDGTDIKTV-NSRLVRHPFSIVIHNDWMYITDWRLDAIIRLHK- 1044

Human   772 VGGAPPTVTLLRSERPPIFEIRMYDAQQQQVG-TNKCRVNNGGCSSLCLATP------------- 822
            :.|....:.:...:...::.:::|..:.|::. |..|..|||||..:|.|.|             
  Fly  1045 LTGEQEEMMVREPQTNRLYGVKVYSHEVQRIADTQPCHRNNGGCQKICFAVPIGASNGTDGVTTS 1109

Human   823 ----GSRQ--CACAEDQVLDADGVTCLANPSYVPPPQCQPG--EFACANSRCIQERWKCDGDNDC 879
                |..|  |:|...:.|..|.|:|:.:||..||.|..|.  :|.|.|.|||.:.|.||||:||
  Fly  1110 SPSFGRLQSRCSCPYGERLADDQVSCIPDPSAEPPVQPCPNSWDFTCNNQRCIPKSWLCDGDDDC 1174

Human   880 LDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCA 944
            ||||||... |.:.||.|:.|:|.:.||||..:.||.:||||::.||..  |...||..:||:||
  Fly  1175 LDNSDEEQN-CTKPTCGSNEFQCRSGRCIPQNFRCDQENDCGDNSDEQE--CGNVTCGTSQFACA 1236

Human   945 SGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTC-NNGRCININWRCDNDNDCGDNSDE 1008
            :|||||..|.||.::||||.|||...||..|| ...|||| ..|.||..:|.||.|:||.|..||
  Fly  1237 NGRCIPNMWKCDSENDCGDSSDEGDFCAEKTC-AYFQFTCPRTGHCIPQSWVCDGDDDCFDKQDE 1300

Human  1009 AGCSH-SCSSTQFKCNSGR-CIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDE-FQCR 1070
            ..|.. ||.:.||||...| |:.|.:.|||..||.|.|||  ..|.:..   |..|:.:: |:|:
  Fly  1301 KDCPPISCLANQFKCADLRQCVEESYKCDGIPDCNDGSDE--VGCPSMG---PNQCNLEKHFRCK 1360

Human  1071 LDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNS 1135
            ..|.|||:.|.|||..||.|.|||:.|..:|  |..:. |.| ::..|:.||::|||.:||.|||
  Fly  1361 STGFCIPIAWHCDGSNDCSDHSDEQDCGQIT--CAQNF-FKC-NNTNCVFKAYICDGKDDCGDNS 1421

Human  1136 DEENCESLACRPP--------------SHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCD--Q 1184
            | |..|. ||.||              |..|.|.|||       ||...||.:||||||.||  :
  Fly  1422 D-EGAEH-ACVPPPFKCPHGQWQCPGVSERCVNITSV-------CDDTPDCPNGSDEGEGCDLAE 1477

Human  1185 CSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCY 1249
            |....|.||..|...| .|.:|.||.|.|:|.|.:||...:.|.....|||:|...|.|..|||.
  Fly  1478 CEHQAGQCSSFCQKTP-NGALCVCPPGSEIGEDGYTCIDSNECDPPGLCSQQCTNTKGSYFCSCT 1541

Human  1250 EGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWT 1314
            :|:||||:..:|::::....|:|.||||.|...||.:.....:...:.|.:|...::....::|:
  Fly  1542 DGYVLEPNKHTCKAVNHTAAFLIISNRHSILVADLKEQGLERVPIIVENVVATASNMHTGTIFWS 1606

Human  1315 DVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRT 1379
            |:...||.|   ||.|  ...:.:|..||...||||.||||.|:||::|.|:.|||:..:|:.|.
  Fly  1607 DMKLKKISR---LDRG--MEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRL 1666

Human  1380 TLLAGDIEHPRAIALDPRDGI--LFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVD 1442
            .|:..:|..||.:.:||..|.  :|||||..: ||:|...|.|..|:|:...  ...||||||:|
  Fly  1667 VLVRENITQPRGMCIDPSPGARWIFWTDWGEN-PRVERIGMDGTMRKTIINT--KIYWPNGLTLD 1728

Human  1443 YLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKW 1507
            ...||:.:.|::.|.|....|:|:|..:||....:|.||.:::|:...:||||.:.|.:..|||:
  Fly  1729 IATKRVYFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANKF 1793

Human  1508 TGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYN--RTVSCACPHLMK 1570
            .|.|.|||....:||..:.|:|.|.|||.||||..:    .|.||||::.:  ...||.|....|
  Fly  1794 RGKNQTVVSHLISQPLSIHVHHASLQPMTPNPCAGS----RCQHLCLLSPSAPEGYSCKCRPGFK 1854

Human  1571 LHKDNTTCYEFKKFLLYARQMEIRGVDLD-----------APYYNYIISFTVPDIDNVTVLDYDA 1624
            |..:.....|...||:..:..:|  |||.           ||         |..|::.|.||:|.
  Fly  1855 LLSEGRCIEEENPFLMVVKGTQI--VDLPLNGGDARAGALAP---------VIGIESSTGLDFDR 1908

Human  1625 REQRVYWSDVRTQAIKRAFINGT-----------GVET-VVSADLPNAHGLAVDWVSRNLFWTSY 1677
            :.:.:||...|....:...|..|           |:|. :|.|    .:.:|.||:.|||    |
  Fly  1909 KGETLYWVQGREDDDENCTIYTTPYGGGNKTLFLGIENGIVGA----PYTIAFDWLGRNL----Y 1965

Human  1678 DTNK--KQINVARLDGSFKNAVV--------QGLEQPHGLVVHPLRGKLYWTDGD------NISM 1726
            ..|:  ..|...|:||..|...:        ..:.:|..:.:.|..|||:|.|..      .|..
  Fly  1966 IGNRVASNIEAVRVDGKQKYRTIILANDGYPNSVSRPKQIALDPTEGKLFWIDEGVLEVPIKIGR 2030

Human  1727 ANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQ-LGKAT 1790
            .:|:|.|..::|.....|..||:|..:..:|:.:|....|...:.:|....:|....|. :.|..
  Fly  2031 VDMNGQNPIVVFQEFAHPESLAVDTEKKMVYYSASNPAVIGVMDYNGDDHTLILMKDSHPMAKPR 2095

Human  1791 ALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNG 1855
            :|.|:..:|::.|.:.|::.......|.....:.::.:.:..|.:|.:...:.|    ||..|||
  Fly  2096 SLGILDHRLYYLDPLYERIVRIDLPHGDNPKTIVDNESDLRSMMIYKKRALMQH----PCQTNNG 2156

Human  1856 DCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHEGIRGIPLDPNDKSDALVPVSG 1920
            .|..||:|....||:|.|..||. :..:..|.....|.:.|..:.|||..|  :|.|:|:||:||
  Fly  2157 GCKHLCIPGPGATRTCACGIGYR-KENEINCVAYKIFAVVSQLDMIRGYSL--SDSSEAMVPISG 2218

Human  1921 TSLAV-GIDFHAENDTIYWVDMG---LSTISRAKRDQTWREDVVTNGIGR--VEGIAVDWIAGNI 1979
            ....: .:|.......|||.:..   .:.|.|::.:.|..:.||.:|||.  :.|:.:||:|||:
  Fly  2219 PGHHILHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGTDLQHVVKDGIGSNGIRGLTIDWVAGNM 2283

Human  1980 YWTD--QGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQYPRIERSRLDGTE 2042
            |:|:  ...:.:||..|:||.|.|::....|.||.:.|:|.|..|:|.::||:|||.::.|||::
  Fly  2284 YFTNVYPHENYVEVCWLDGSNRKVLVKTTTDAPRELAVNPIKRLLYWIDYGQHPRIGKALLDGSK 2348

Human  2043 RVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREVVLSSNNMDM---FSVSVF 2104
            ...||...||.|..:::|.|...:||.|::.|.|::|.. .|.||:::    ..|:   ..::|:
  Fly  2349 WTPLVTSGISLPRDLTIDMQTHDIYWVDSKLDTIQKISY-NGANRKII----RRDLPNPMGIAVY 2408

Human  2105 EDFIYWSDRTHANGSIKRGSKDNATD-SVPLRTGIGVQLKDIKVF--NRDRQKGTNVCA-VANGG 2165
            .:.:||.||...  ::.:.||.:|.: :..:||.: .:|:||.::  |...|..||.|| :.|||
  Fly  2409 LNDVYWVDRNLM--TVFKASKHSANETATSVRTNL-EKLRDIAIYNINNQPQDDTNPCAHLGNGG 2470

Human  2166 CQQLCL-----------YRGRGQRACACAHGMLAEDGASCREYAGYLLYSERTILKSIHLSDERN 2219
            |.|||.           ..||..| |.||.|.|:.|...|.....||:::.||.:::::| |..:
  Fly  2471 CDQLCFSFPPDGGASGTSGGRNFR-CECATGKLSADERKCEVVNEYLVFATRTEIRAVNL-DPHS 2533

Human  2220 LNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIH-FGNI--QQINDDGSRRITIVEN 2281
            ...|..|.   .::.||:.|.||:       ..||:.::.|. :..|  .:.|..|...||:|.|
  Fly  2534 TEVPFTPL---TNLTNVVGLDFDF-------AHNRMLYTQIRPWAKIAYTKANKPGHDDITVVLN 2588

Human  2282 VG-SVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNL 2345
            .| :.||:||......:|||..:.::|....:|.:.        ::.::..:.|||.|||.|...
  Fly  2589 KGINPEGIAYDWTQQKIYWTDSSNNSIYAMNLDGSE--------LVMIARVERPRAIVLDPCNGT 2645

Human  2346 MFWTNWNEQHPS--IMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDG 2408
            :|:|:|.....|  |.|..::|:....:::||:..|:|||||:...:||::||..:||||.:.||
  Fly  2646 LFFTDWGRFGTSGKIFRTTMAGSLKRAIVDKDLSQPSGLAIDYDERRLYWTDAVREKIERSDLDG 2710

Human  2409 SHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVAND 2473
            .:| .:|.:..::||.:.|:..:|:|||...|.|.||.||.|:||..:...:...|..|...::|
  Fly  2711 QNR-ELLVAATIYPFAITVFRNYIYWTDLQLRGVYRAEKHTGANMVEMVKRLEDSPRDIRIYSSD 2774

Human  2474 TNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGG-RILQDDLTCRAVNSSCRAQDEFECANGEC 2537
            ...|.::|||||||||...|.....|...|.|... :::.:...|...|::|.| .:|.|.||.|
  Fly  2775 RQKCNVNPCRINNGGCAQSCHPAPNGKAECKCDDSTKVVNEGRMCAPRNNTCEA-SKFYCKNGRC 2838

Human  2538 INFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNK 2602
            |:...:|||...|.|.|||.|:||....|.....:|:||||:.....|:..:||.|||||:.|..
  Fly  2839 ISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNNGRCIFKSWKCDHENDCKDGSDELGCVY 2903

Human  2603 TACGVGEFRCRDGTCIGNSSRCNQFVDCED--ASDE------MNCSATDC-SSYFRLGVKGVLFQ 2658
            ..|..|||.|.:|.||..:..||...||:|  .|||      ||   |.| :::.:         
  Fly  2904 PPCVDGEFTCANGRCIPQAQVCNGVNDCKDNATSDETHERCPMN---TTCPANHLK--------- 2956

Human  2659 PCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEH 2723
             ||:|::|..|.|:|||.|||||.||| |.....:..||.|.|.||:.||||.:|.||.:|||..
  Fly  2957 -CEKTNICVEPYWLCDGDNDCGDNSDE-DPLHCGQRTCPTNSFRCPNHRCIPATWYCDGDDDCGD 3019

Human  2724 GEDE--THC---NKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDE--AAHCEGKTCG-PSSFS 2780
            |.||  .:|   .:.|....|.|.|..||.:.::|||.:||.|.|||  ...|..:.|. .:.|:
  Fly  3020 GADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDCLDNSDEDNRHQCNDRKCDEETEFT 3084

Human  2781 CPGTH-----VCVPERWLCDGDKDCADGADESIAA-GCLYNSTCDDREFMCQNRQCIPKHFVCDH 2839
            |....     .|:|::|:||||.||.|||||:... .|.....|.:..|.|.|.:||.|.::|||
  Fly  3085 CVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQQPCGEDMFTCGNGRCINKGWICDH 3149

Human  2840 DRDCADGSDESPEC--EYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEH 2902
            |.||.||:||...|  :|.||...||.|.|.:|:.: |..||||:||.|.|||.    .|..:..
  Fly  3150 DNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIRN-QSRCDGEDDCGDHSDEV----GCAKENI 3209

Human  2903 KCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERG-CHINECLSRKLSGCSQDCEDLKIGFKCR 2966
            .| ...||.|::|:|:...|:||...||.|.|||.. |:::||...:::.|...|.|...|:.|.
  Fly  3210 TC-PQGQFACTNGQCIDYNLVCNKYPDCADESDEPAHCNVDECAKVEINQCGHKCVDTLTGYYCD 3273

Human  2967 CRPGFRLKDDGRTCADVDEC-STTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPF 3030
            |..|::|..||:.||||||| .....|||.|.||.|.:.|.|.|.|..|..|.|:||......|:
  Fly  3274 CNEGYKLLADGKACADVDECLEQPGACSQHCSNTPGGFYCKCDETYYERQNDEHTCKRKDKIPPW 3338

Human  3031 LIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQV 3095
            |||.|:||:|.:::||..|.|:.|.|.|.||||||.||:.:|:.|||.: ::.|..:....:...
  Fly  3339 LIFTNKYYVRNMSVDGHQYNLMHQDLMNVVALDFDIREEYMYFCDVTAK-TIFRAKYGEADDEMP 3402

Human  3096 LHRTGLSNPD-----GLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQ 3155
            ..|..:...|     |:|:||||..|||.|:....::||:|:|:.|..| .||:.:|||:||...
  Fly  3403 PEREAVIRHDSHGLEGIAIDWVGRKLYWLDRHSKNLDVSELDGSKRKTL-RSGVVDPRAIVVHPG 3466

Human  3156 NGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTK--ITWPNGLTLDYVTERIYWADAREDYIEFASL 3218
            .||||:|.|...:.|.::|||||:.|.|::..  |.|||.|::||.|:|||||||..|||.:|.|
  Fly  3467 IGYLYFTSWHLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADL 3531

Human  3219 DGSNRHVVLS-QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHRPMDLHVFH 3282
            :|.:||.||| ..:||:|||:||:||:||:||..|:|.||:|..|.|.|:|.:|.|||.|||:.|
  Fly  3532 EGRHRHTVLSGSKVPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYDLHINH 3596

Human  3283 ALRQPDVPNHPCKVNNGGCSNLCLLSPG--------GGH--------KCACPTNFYLGSDGRTCV 3331
            .|||....| ||..||||||:|||::|.        .|:        |||||..|||..|.:|||
  Fly  3597 PLRQLPYTN-PCGTNNGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQFYLARDMKTCV 3660

Human  3332 SNCTASQFVC--KNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICD 3394
            :||||.|.:|  :::||||::||||.|.||.|.||||..|....||.|.|||....||..|.|||
  Fly  3661 ANCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCAPRHCRAGTFQCKNTNCTPSATICD 3725

Human  3395 GDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERD--CPEVTCAP-N 3456
            |.:||.|.|||.|||: .|..|.|||.::.|||...:||:|..:|.||.||..  |.:.||.| .
  Fly  3726 GVDDCGDRSDEQNCDL-PCPLSDFKCKSSGRCILDSWRCDGDADCKDGSDEDPAVCFKRTCDPKT 3789

Human  3457 QFQCSITKRCIPRVWVCDRDNDCVDGSDEPA-NCTQMTCGVDEFRC--KDSGRCIPARWKCDGED 3518
            :|.|. ..||||::|:||.||||.|.||||| .|.|..|.....||  :.:.||||....|||:|
  Fly  3790 EFSCK-NGRCIPQLWMCDFDNDCGDDSDEPAYMCRQRNCTTGWQRCPGQSNYRCIPKWLFCDGKD 3853

Human  3519 DCGDGSDEPKEECDERTCEP-YQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCT----PRPCSES 3578
            ||.|.|||..|.|.:  |.| ..|:|.||||:|.:|.||:.:||||.|||....    .|.||||
  Fly  3854 DCRDNSDELPENCPK--CNPETDFKCGNNRCIPKQWMCDFADDCGDASDENEAVCKGRYRECSES 3916

Human  3579 EFSCANGRCIAGRWKCDGDHDCADGSDEKDCTP-RCDMDQFQCKSGHCIPLRWRCDADADCMDGS 3642
            ||.|.||:||:.||:||.:.||.|.|||..|.. :|....|||.|||||...:|||.|.||.|.|
  Fly  3917 EFRCGNGKCISSRWQCDHEDDCGDNSDEMHCEGYQCKNGTFQCASGHCIASYFRCDGDRDCRDMS 3981

Human  3643 DEEACG---TGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCK 3704
            ||..|.   .|.|.||...|||||.||..|:..|||.|||||.|||:|..|:.|.|...|.|:|.
  Fly  3982 DEVGCPPRFPGGRYCPESRFQCNNNLCVSLSDLCDGTDDCGDGSDEDPSVCSDFNCDTLRRFQCS 4046

Human  3705 NDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGD 3769
            |:| |:...:.|||.||||||:||.:.....:....|....::.|.|:.|:..|..|:..|||||
  Fly  4047 NER-CVARYQICDGVDNCGDGSDENNMTLCASKQKPCDLYTQYQCANKHCIERSQVCDFSDDCGD 4110

Human  3770 GSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAY-CACRSGF-HTVPGQPGCQDINECL-RF 3831
            .|||..|    ..||..:.|:..|.:..|.......| |.|..|: .....:..|.|::||| |.
  Fly  4111 ASDELGC----HHTSSCSEANRGGCQQHCHNLTDGGYICTCYPGYIIAADNKKKCSDVDECLTRQ 4171

Human  3832 GTCSQLCNNTKGGHLCSCARNFMKT---HNTCKAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQA 3893
            .|||..|:|..|.:.|||...|..|   ...|:||..:..:|:: :..|||.|   :.|.:.|.|
  Fly  4172 HTCSHQCHNLNGTYSCSCREGFHLTDGASGVCRAEKEDVILLFV-NGQEIRGL---NWHKSEEFA 4232

Human  3894 FQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTTSNRHRRQIDRGVTH-LNISGL 3957
            ....|. ||:|:|...:...|:|.:.:..||....:..|..      .|.:|  |... ||:.|.
  Fly  4233 VIAAEK-RIEALDYDAQQQIVFWADSYDKTIKRSYMVNAID------GRAKI--GFAQDLNMKGG 4288

Human  3958 KMPRGIAIDWVAGNVYWTD------SGRDVIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMY 4016
            ..|..:|:||:|.|:|||:      ..|..:.||:..|..|:::::..::.|.:|.|:|..|.:|
  Fly  4289 SKPTAVAVDWLASNLYWTEMDRTGSKPRGRVMVAKTDGRYRRSIVNAGLEVPTSIAVNPQLGRIY 4353

Human  4017 WSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNER-LYWADAKLSVIGSIRLNGT--D 4078
            |||.|:.||||.:.|||:.|..|:.:.|:.|.||.:||..:. :||.|.||:.|.|:|.:|:  .
  Fly  4354 WSDAGSAPKIEVSWMDGSKRRPLITEMIRHPAGLTIDYSQDHIIYWVDTKLNAIESMRADGSRRK 4418

Human  4079 PIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHK 4143
            .||..|.   |.||.|:|:||..::.:|.....:.:..|||....|.|...:.:.|.:.:||..:
  Fly  4419 AIVRGDQ---LRHPVSLDLFESNMFWMTRDTGELVRQDKFGRGVQVVLHRYIVNPSGLKVYHDKR 4480

Human  4144 -QPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPP--------------D 4193
             ...:.||||...|..||||.|.|..|.||:             :..|||              :
  Fly  4481 YNTSLPNPCDNSTCSHLCLLVPGGHRCACPD-------------ASGPPPSHRSTAEVICNAAAE 4532

Human  4194 APRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCE 4232
            .|||......|.|||.|..:|:.:..|.|:.::.|:.||
  Fly  4533 HPRPAPRICPCQNGGLCKEDAQGELLCECRTQFVGEHCE 4571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRP1NP_002323.2 LDLa 26..59 CDD:197566 13/31 (42%)
Ldl_recept_a 71..104 CDD:395011 16/37 (43%)
FXa_inhibition 119..148 CDD:464251 10/28 (36%)
FXa_inhibition 158..188 CDD:464251 16/29 (55%)
LY 275..314 CDD:214531 8/38 (21%)
LDL-receptor class B 1 292..334 12/41 (29%)
LY 316..358 CDD:214531 17/41 (41%)
LDL-receptor class B 2 335..378 14/42 (33%)
LY 361..401 CDD:214531 18/39 (46%)
LDL-receptor class B 3 379..422 18/42 (43%)
FXa_inhibition 486..519 CDD:464251 12/37 (32%)
LY 551..593 CDD:214531 15/45 (33%)
LDL-receptor class B 4 571..613 18/41 (44%)
LY 594..633 CDD:214531 16/38 (42%)
LDL-receptor class B 5 614..659 17/44 (39%)
LY 640..689 CDD:214531 17/48 (35%)
LDL-receptor class B 6 660..710 17/49 (35%)
LY <700..733 CDD:214531 16/32 (50%)
LDL-receptor class B 7 711..754 15/42 (36%)
FXa_inhibition 807..842 CDD:464251 16/53 (30%)
LDLa 853..885 CDD:197566 19/33 (58%)
LDLa 895..928 CDD:238060 16/32 (50%)
LDLa 935..967 CDD:197566 19/31 (61%)
LDLa 978..1011 CDD:238060 16/33 (48%)
LDLa 1015..1048 CDD:238060 17/33 (52%)
LDLa 1062..1097 CDD:238060 17/35 (49%)
LDLa 1104..1140 CDD:238060 16/35 (46%)
LDLa 1145..1178 CDD:238060 15/46 (33%)
FXa_inhibition 1185..1221 CDD:464251 14/35 (40%)
LDL-receptor class B 8 1309..1355 17/45 (38%)
Vgb 1310..>1503 CDD:443399 74/194 (38%)
LY 1336..1376 CDD:214531 19/39 (49%)
LDL-receptor class B 9 1356..1398 16/41 (39%)
LY 1380..1423 CDD:214531 17/44 (39%)
LDL-receptor class B 10 1399..1445 20/47 (43%)
LDL-receptor class B 11 1446..1490 14/43 (33%)
LDL-receptor class B 12 1491..1531 17/39 (44%)
LY 1613..1649 CDD:214531 10/46 (22%)
LDL-receptor class B 13 1627..1669 12/53 (23%)
LY 1650..1693 CDD:214531 15/45 (33%)
LDL-receptor class B 14 1670..1713 12/52 (23%)
LY 1697..1734 CDD:214531 10/50 (20%)
LDL-receptor class B 15 1714..1753 14/44 (32%)
LY 1734..1775 CDD:214531 9/40 (23%)
LDL-receptor class B 16 1754..1798 9/44 (20%)
FXa_inhibition 1850..1886 CDD:464251 14/35 (40%)
YncE 1872..2084 CDD:442618 73/219 (33%)
LDL-receptor class B 17 1934..1976 14/46 (30%)
LY 1959..1999 CDD:214531 18/43 (42%)
LDL-receptor class B 18 1977..2019 16/43 (37%)
LDL-receptor class B 19 2020..2063 16/42 (38%)
Ldl_recept_b 2020..2061 CDD:459654 15/40 (38%)
LY 2045..2087 CDD:214531 14/41 (34%)
LDL-receptor class B 20 2064..2107 11/45 (24%)
FXa_inhibition 2159..2194 CDD:464251 18/46 (39%)
LDL-receptor class B 21 2253..2294 15/44 (34%)
LDL-receptor class B 22 2295..2343 11/47 (23%)
LDL-receptor class B 23 2344..2388 15/45 (33%)
Ldl_recept_b 2344..2386 CDD:459654 14/43 (33%)
LY 2370..2411 CDD:214531 18/40 (45%)
LDL-receptor class B 24 2389..2431 15/41 (37%)
LDL-receptor class B 25 2432..2473 15/40 (38%)
FXa_inhibition 2482..2517 CDD:464251 12/35 (34%)
LDLa 2527..2557 CDD:238060 13/29 (45%)
LDLa 2566..2600 CDD:238060 14/33 (42%)
LDLa 2605..2639 CDD:238060 17/41 (41%)
LDLa <2666..2688 CDD:238060 14/21 (67%)
LDLa 2696..2730 CDD:238060 19/35 (54%)
LDLa 2734..2765 CDD:197566 13/30 (43%)
LDLa 2773..2806 CDD:197566 15/38 (39%)
LDLa 2817..2849 CDD:197566 15/31 (48%)
LDLa 2857..2890 CDD:197566 16/32 (50%)
LDLa 2907..2939 CDD:238060 14/32 (44%)
cEGF 2964..2985 CDD:463661 10/20 (50%)
EGF_CA 2982..>3011 CDD:214542 15/29 (52%)
LY 3049..3093 CDD:214531 18/43 (42%)
LDL-receptor class B 26 3069..3113 11/48 (23%)
LY 3094..3136 CDD:214531 16/46 (35%)
LDL-receptor class B 27 3114..3156 17/41 (41%)
LY 3138..3180 CDD:214531 20/41 (49%)
LDL-receptor class B 28 3157..3200 21/44 (48%)
LY 3182..3223 CDD:214531 22/42 (52%)
LDL-receptor class B 29 3201..3243 25/42 (60%)
LY 3224..3264 CDD:214531 23/40 (58%)
LDL-receptor class B 30 3244..3284 21/39 (54%)
FXa_inhibition 3294..3330 CDD:464251 21/51 (41%)
LDLa 3334..3365 CDD:238060 18/32 (56%)
LDLa 3374..3408 CDD:238060 19/33 (58%)
LDLa 3413..3448 CDD:238060 16/36 (44%)
LDLa 3452..3485 CDD:197566 18/33 (55%)
LDLa 3493..3526 CDD:197566 15/34 (44%)
LDLa 3536..3570 CDD:238060 19/34 (56%)
LDLa 3575..3609 CDD:238060 21/33 (64%)
LDLa 3613..3647 CDD:238060 19/33 (58%)
LDLa 3653..3685 CDD:197566 19/31 (61%)
LDLa 3695..3731 CDD:238060 18/35 (51%)
LDLa 3746..3776 CDD:238060 13/29 (45%)
YncE 3862..4064 CDD:442618 67/209 (32%)
LDL-receptor class B 31 3912..3954 9/42 (21%)
Recognition site for proteolytical processing. /evidence=ECO:0000255 3940..3943 0/2 (0%)
LY 3955..3992 CDD:214531 14/42 (33%)
LDL-receptor class B 32 3970..4012 13/47 (28%)
LDL-receptor class B 33 4013..4056 21/42 (50%)
Ldl_recept_b 4013..4054 CDD:459654 19/40 (48%)
LY 4037..4078 CDD:214531 16/43 (37%)
LDL-receptor class B 34 4057..4101 19/46 (41%)
Interaction with MAFB. /evidence=ECO:0000250|UniProtKB:Q91ZX7 4445..4544
NPXY motif 4502..4507
mglNP_572563.3 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060 16/39 (41%)
LDLa 371..412 CDD:238060 18/40 (45%)
vWFA <447..488 CDD:469594 22/40 (55%)
YncE <492..634 CDD:442618 37/161 (23%)
NHL 573..>716 CDD:302697 52/160 (33%)
NHL repeat 573..610 CDD:271320 9/51 (18%)
NHL repeat 616..654 CDD:271320 16/40 (40%)
NHL repeat 657..693 CDD:271320 18/35 (51%)
FXa_inhibition 763..805 CDD:464251 14/45 (31%)
YvrE 854..>992 CDD:442613 55/147 (37%)
LY 922..964 CDD:214531 17/48 (35%)
LY 973..1007 CDD:214531 15/33 (45%)
Ldl_recept_a 1188..1223 CDD:395011 17/36 (47%)
LDLa 1227..1259 CDD:197566 19/31 (61%)
LDLa 1268..1303 CDD:238060 17/35 (49%)
LDLa 1308..1343 CDD:238060 17/36 (47%)
LDLa 1356..1387 CDD:238060 16/30 (53%)
LDLa 1391..1423 CDD:197566 16/36 (44%)
LDLa 1435..1469 CDD:197566 12/40 (30%)
FXa_inhibition 1522..1553 CDD:464251 14/30 (47%)
LY 1625..1665 CDD:214531 20/39 (51%)
LY 1667..1711 CDD:214531 17/44 (39%)
Ldl_recept_b 1690..1729 CDD:459654 18/41 (44%)
LY 1712..1754 CDD:214531 15/43 (35%)
LY 1986..2037 CDD:214531 10/50 (20%)
FXa_inhibition 2151..>2179 CDD:464251 13/27 (48%)
LY 2259..2305 CDD:214531 18/45 (40%)
Ldl_recept_b 2326..2366 CDD:459654 15/39 (38%)
LY 2352..2392 CDD:214531 14/40 (35%)
NHL 2579..>2711 CDD:302697 46/139 (33%)
NHL repeat 2593..2622 CDD:271320 8/28 (29%)
NHL repeat 2634..2678 CDD:271320 15/43 (35%)
LY 2671..2713 CDD:214531 18/41 (44%)
LDLa 2867..2901 CDD:238060 14/33 (42%)
LDLa 2906..2941 CDD:238060 16/34 (47%)
LDLa 2950..2983 CDD:238060 18/43 (42%)
LDLa 3034..3066 CDD:197566 13/31 (42%)
LDLa 3080..3115 CDD:197566 14/34 (41%)
LDLa 3128..3159 CDD:238060 15/30 (50%)
LDLa 3170..3204 CDD:238060 17/38 (45%)
LDLa 3210..3242 CDD:197566 13/32 (41%)
FXa_inhibition 3259..3287 CDD:464251 10/27 (37%)
FXa_inhibition 3293..3329 CDD:464251 15/35 (43%)
LY 3362..3394 CDD:214531 16/32 (50%)
LY 3406..3448 CDD:214531 15/41 (37%)
Ldl_recept_b 3468..3511 CDD:459654 19/42 (45%)
LY 3498..3536 CDD:214531 21/37 (57%)
LY 3536..3578 CDD:214531 24/41 (59%)
FXa_inhibition 3607..3659 CDD:464251 21/51 (41%)
LDLa 3663..3696 CDD:238060 18/32 (56%)
LDLa 3705..3739 CDD:238060 19/33 (58%)
LDLa 3743..3775 CDD:197566 14/31 (45%)
LDLa 3784..3817 CDD:197566 18/33 (55%)
LDLa 3827..3861 CDD:197566 15/33 (45%)
LDLa 3871..3901 CDD:197566 16/29 (55%)
LDLa 3913..3947 CDD:238060 21/33 (64%)
LDLa 3952..3986 CDD:238060 19/33 (58%)
LDLa 3996..4027 CDD:197566 19/30 (63%)
LDLa 4043..4071 CDD:238060 16/28 (57%)
LDLa 4086..4117 CDD:238060 13/30 (43%)
EGF_CA 4163..4194 CDD:214542 14/30 (47%)
NHL 4276..>4426 CDD:302697 56/154 (36%)
NHL repeat 4291..4336 CDD:271320 14/44 (32%)
Ldl_recept_b 4350..4391 CDD:459654 19/40 (48%)
LY 4374..4417 CDD:214531 16/42 (38%)
NHL repeat 4376..4422 CDD:271320 17/45 (38%)
Blue background indicates that the domain is not in the aligned region.

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